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Efficient Generation of P53 Biallelic Mutations in Diannan Miniature Pigs Using RNA-Guided Base Editing

The base editing 3 (BE3) system, a single-base gene editing technology developed using CRISPR/Cas9n, has a broad range of applications for human disease model construction and gene therapy, as it is highly efficient, accurate, and non-destructive. P53 mutations are present in more than 50% of human...

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Detalles Bibliográficos
Autores principales:	Li, Honghui, Cheng, Wenmin, Chen, Bowei, Pu, Shaoxia, Fan, Ninglin, Zhang, Xiaolin, Jiao, Deling, Shi, Dejia, Guo, Jianxiong, Li, Zhuo, Qing, Yubo, Jia, Baoyu, Zhao, Hong-Ye, Wei, Hong-Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706133/ https://www.ncbi.nlm.nih.gov/pubmed/34947951 http://dx.doi.org/10.3390/life11121417

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