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Deficiency of the Ribosomal Protein uL5 Leads to Significant Rearrangements of the Transcriptional and Translational Landscapes in Mammalian Cells

Protein uL5 (formerly called L11) is an integral component of the large (60S) subunit of the human ribosome, and its deficiency in cells leads to the impaired biogenesis of 60S subunits. Using RNA interference, we reduced the level of uL5 in HEK293T cells by three times, which caused an almost propo...

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Detalles Bibliográficos
Autores principales:	Babaylova, Elena S., Gopanenko, Alexander V., Tupikin, Alexey E., Kabilov, Marsel R., Malygin, Alexey A., Karpova, Galina G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706191/ https://www.ncbi.nlm.nih.gov/pubmed/34948282 http://dx.doi.org/10.3390/ijms222413485

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