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Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion

Metal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulati...

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Autores principales: Fangaia, Sónia I. G., Nicolau, Pedro M. G., Guerra, Fernando A. D. R. A., Rodrigo, M. Melia, Utzeri, Gianluca, Cabral, Ana M. T. D. P. V., Valente, Artur J. M., Esteso, Miguel A., Ribeiro, Ana C. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706250/
https://www.ncbi.nlm.nih.gov/pubmed/34948060
http://dx.doi.org/10.3390/ijms222413266
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author Fangaia, Sónia I. G.
Nicolau, Pedro M. G.
Guerra, Fernando A. D. R. A.
Rodrigo, M. Melia
Utzeri, Gianluca
Cabral, Ana M. T. D. P. V.
Valente, Artur J. M.
Esteso, Miguel A.
Ribeiro, Ana C. F.
author_facet Fangaia, Sónia I. G.
Nicolau, Pedro M. G.
Guerra, Fernando A. D. R. A.
Rodrigo, M. Melia
Utzeri, Gianluca
Cabral, Ana M. T. D. P. V.
Valente, Artur J. M.
Esteso, Miguel A.
Ribeiro, Ana C. F.
author_sort Fangaia, Sónia I. G.
collection PubMed
description Metal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulative effect in the body. The effect of the chlorhexidine digluconate, which is commonly used in mouthwash formulations, on the transport of these salts is evaluated in this paper by using the Taylor dispersion technique, which will allow an assessment of how the presence of chlorhexidine digluconate (either in aqueous solution or in a commercial formulation) may affect the diffusion of metal ions. The ternary mutual diffusion coefficients of metal ions (Co and Cr) in the presence of chlorhexidine digluconate, in an artificial saliva media, were measured. Significant coupled diffusion of CoCl(2) (and CrCl(3)) and chlorhexidine digluconate is observed by analysis of the non-zero values of the cross-diffusion coefficients, D(12) and D(21). The observed interactions between metal ions and chlorhexidine digluconate suggest that the latter might be considered as an advantageous therapeutic agent, once they contribute to the reduction of the concentration of those ions inside the mouth.
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spelling pubmed-87062502021-12-25 Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion Fangaia, Sónia I. G. Nicolau, Pedro M. G. Guerra, Fernando A. D. R. A. Rodrigo, M. Melia Utzeri, Gianluca Cabral, Ana M. T. D. P. V. Valente, Artur J. M. Esteso, Miguel A. Ribeiro, Ana C. F. Int J Mol Sci Article Metal ions such as cobalt (II) and chromium (III) might be present in the oral cavity, as a consequence of the corrosion of Co-Cr dental alloys. The diffusion of such metal ions into the organism, carried by saliva, can cause health problems as a consequence of their toxicity, enhanced by a cumulative effect in the body. The effect of the chlorhexidine digluconate, which is commonly used in mouthwash formulations, on the transport of these salts is evaluated in this paper by using the Taylor dispersion technique, which will allow an assessment of how the presence of chlorhexidine digluconate (either in aqueous solution or in a commercial formulation) may affect the diffusion of metal ions. The ternary mutual diffusion coefficients of metal ions (Co and Cr) in the presence of chlorhexidine digluconate, in an artificial saliva media, were measured. Significant coupled diffusion of CoCl(2) (and CrCl(3)) and chlorhexidine digluconate is observed by analysis of the non-zero values of the cross-diffusion coefficients, D(12) and D(21). The observed interactions between metal ions and chlorhexidine digluconate suggest that the latter might be considered as an advantageous therapeutic agent, once they contribute to the reduction of the concentration of those ions inside the mouth. MDPI 2021-12-09 /pmc/articles/PMC8706250/ /pubmed/34948060 http://dx.doi.org/10.3390/ijms222413266 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fangaia, Sónia I. G.
Nicolau, Pedro M. G.
Guerra, Fernando A. D. R. A.
Rodrigo, M. Melia
Utzeri, Gianluca
Cabral, Ana M. T. D. P. V.
Valente, Artur J. M.
Esteso, Miguel A.
Ribeiro, Ana C. F.
Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
title Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
title_full Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
title_fullStr Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
title_full_unstemmed Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
title_short Effect of Cobalt and Chromium Ions on the Chlorhexidine Digluconate as Seen by Intermolecular Diffusion
title_sort effect of cobalt and chromium ions on the chlorhexidine digluconate as seen by intermolecular diffusion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706250/
https://www.ncbi.nlm.nih.gov/pubmed/34948060
http://dx.doi.org/10.3390/ijms222413266
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