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Carboxyl-Rich Carbon Dots as Highly Selective and Sensitive Fluorescent Sensor for Detection of Fe(3+) in Water and Lactoferrin
As lactoferrin (LF) plays an essential role in physiological processes, the detection of LF has attracted increasing attention in the field of disease diagnosis. However, most current methods require expensive equipment, laborious pretreatment, and long processing time. In this work, carboxyl-rich c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706276/ https://www.ncbi.nlm.nih.gov/pubmed/34960868 http://dx.doi.org/10.3390/polym13244317 |
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author | Wang, Xinxin Zhao, Yanan Wang, Ting Liang, Yan Zhao, Xiangzhong Tang, Ke Guan, Yutong Wang, Hua |
author_facet | Wang, Xinxin Zhao, Yanan Wang, Ting Liang, Yan Zhao, Xiangzhong Tang, Ke Guan, Yutong Wang, Hua |
author_sort | Wang, Xinxin |
collection | PubMed |
description | As lactoferrin (LF) plays an essential role in physiological processes, the detection of LF has attracted increasing attention in the field of disease diagnosis. However, most current methods require expensive equipment, laborious pretreatment, and long processing time. In this work, carboxyl-rich carbon dots (COOH-CDs) were facilely prepared through a one-step, low-cost hydrothermal process with tartaric acid as the precursor. The COOH-CDs had abundant carboxyl on the surface and showed strong blue emission. Moreover, COOH-CDs were used as a fluorescent sensor toward Fe(3+) and showed high selectivity for Fe(3+) with the limit of detection (LoD) of 3.18 nM. Density functional theory (DFT) calculations were performed to reveal the mechanism of excellent performance for Fe(3+) detection. Meanwhile, COOH-CDs showed no obvious effect on lactobacillus plantarum growth, which means that COOH-CDs have good biocompatibility. Due to the nontoxicity and excellent detection performance for Fe(3+), COOH-CDs were employed as a fluorescent sensor toward LF and showed satisfying performance with an LoD of 0.776 µg/mL, which was better than those of the other methods. |
format | Online Article Text |
id | pubmed-8706276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87062762021-12-25 Carboxyl-Rich Carbon Dots as Highly Selective and Sensitive Fluorescent Sensor for Detection of Fe(3+) in Water and Lactoferrin Wang, Xinxin Zhao, Yanan Wang, Ting Liang, Yan Zhao, Xiangzhong Tang, Ke Guan, Yutong Wang, Hua Polymers (Basel) Article As lactoferrin (LF) plays an essential role in physiological processes, the detection of LF has attracted increasing attention in the field of disease diagnosis. However, most current methods require expensive equipment, laborious pretreatment, and long processing time. In this work, carboxyl-rich carbon dots (COOH-CDs) were facilely prepared through a one-step, low-cost hydrothermal process with tartaric acid as the precursor. The COOH-CDs had abundant carboxyl on the surface and showed strong blue emission. Moreover, COOH-CDs were used as a fluorescent sensor toward Fe(3+) and showed high selectivity for Fe(3+) with the limit of detection (LoD) of 3.18 nM. Density functional theory (DFT) calculations were performed to reveal the mechanism of excellent performance for Fe(3+) detection. Meanwhile, COOH-CDs showed no obvious effect on lactobacillus plantarum growth, which means that COOH-CDs have good biocompatibility. Due to the nontoxicity and excellent detection performance for Fe(3+), COOH-CDs were employed as a fluorescent sensor toward LF and showed satisfying performance with an LoD of 0.776 µg/mL, which was better than those of the other methods. MDPI 2021-12-09 /pmc/articles/PMC8706276/ /pubmed/34960868 http://dx.doi.org/10.3390/polym13244317 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Xinxin Zhao, Yanan Wang, Ting Liang, Yan Zhao, Xiangzhong Tang, Ke Guan, Yutong Wang, Hua Carboxyl-Rich Carbon Dots as Highly Selective and Sensitive Fluorescent Sensor for Detection of Fe(3+) in Water and Lactoferrin |
title | Carboxyl-Rich Carbon Dots as Highly Selective and Sensitive Fluorescent Sensor for Detection of Fe(3+) in Water and Lactoferrin |
title_full | Carboxyl-Rich Carbon Dots as Highly Selective and Sensitive Fluorescent Sensor for Detection of Fe(3+) in Water and Lactoferrin |
title_fullStr | Carboxyl-Rich Carbon Dots as Highly Selective and Sensitive Fluorescent Sensor for Detection of Fe(3+) in Water and Lactoferrin |
title_full_unstemmed | Carboxyl-Rich Carbon Dots as Highly Selective and Sensitive Fluorescent Sensor for Detection of Fe(3+) in Water and Lactoferrin |
title_short | Carboxyl-Rich Carbon Dots as Highly Selective and Sensitive Fluorescent Sensor for Detection of Fe(3+) in Water and Lactoferrin |
title_sort | carboxyl-rich carbon dots as highly selective and sensitive fluorescent sensor for detection of fe(3+) in water and lactoferrin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706276/ https://www.ncbi.nlm.nih.gov/pubmed/34960868 http://dx.doi.org/10.3390/polym13244317 |
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