Single-Dose P2 X4R Single-Chain Fragment Variable Antibody Permanently Reverses Chronic Pain in Male Mice

Non-opioid single-chain variable fragment (scFv) small antibodies were generated as pain-reducing block of P2X4R receptor (P2X4R). A panel of scFvs targeting an extracellular peptide sequence of P2X4R was generated followed by cell-free ribosome display for recombinant antibody selection. After thre...

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Detalles Bibliográficos
Autores principales: Westlund, Karin N., Montera, Marena A., Goins, Aleyah E., Alles, Sascha R. A., Suri, Nikita, McIlwrath, Sabrina L., Bartel, Robyn, Durvasula, Ravi V., Kunamneni, Adinarayana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706307/
https://www.ncbi.nlm.nih.gov/pubmed/34948407
http://dx.doi.org/10.3390/ijms222413612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706307/
https://www.ncbi.nlm.nih.gov/pubmed/34948407
http://dx.doi.org/10.3390/ijms222413612

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