Cargando…
Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination
Recently several patients, who developed Guillain–Barré syndrome characterized by prominent bifacial weakness after ChAdOx1 nCoV-19 vaccination, were described from different centers. We recently observed a patient who developed a similar syndrome, later in the follow up he showed worsening of the n...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706382/ https://www.ncbi.nlm.nih.gov/pubmed/34960248 http://dx.doi.org/10.3390/vaccines9121502 |
_version_ | 1784622179028041728 |
---|---|
author | Bagella, Caterina Francesca Corda, Davide G. Zara, Pietro Elia, Antonio Emanuele Ruiu, Elisa Sechi, Elia Solla, Paolo |
author_facet | Bagella, Caterina Francesca Corda, Davide G. Zara, Pietro Elia, Antonio Emanuele Ruiu, Elisa Sechi, Elia Solla, Paolo |
author_sort | Bagella, Caterina Francesca |
collection | PubMed |
description | Recently several patients, who developed Guillain–Barré syndrome characterized by prominent bifacial weakness after ChAdOx1 nCoV-19 vaccination, were described from different centers. We recently observed a patient who developed a similar syndrome, later in the follow up he showed worsening of the neuropathy two months after the initial presentation. Repeat EMG showed reduced nerve sensory and motor conduction velocities of both upper and lower limbs, and a diagnosis of chronic inflammatory demyelinating polyneuropathy (typical CIDP) was made according to established criteria. Our report expands on the possible outcomes in patients who develop Guillain–Barrè syndrome after COVID-19 vaccinations and suggest that close monitoring after the acute phase is needed in these patients to exclude a chronic evolution of the disease, which has important implications for long-term treatment. |
format | Online Article Text |
id | pubmed-8706382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87063822021-12-25 Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination Bagella, Caterina Francesca Corda, Davide G. Zara, Pietro Elia, Antonio Emanuele Ruiu, Elisa Sechi, Elia Solla, Paolo Vaccines (Basel) Case Report Recently several patients, who developed Guillain–Barré syndrome characterized by prominent bifacial weakness after ChAdOx1 nCoV-19 vaccination, were described from different centers. We recently observed a patient who developed a similar syndrome, later in the follow up he showed worsening of the neuropathy two months after the initial presentation. Repeat EMG showed reduced nerve sensory and motor conduction velocities of both upper and lower limbs, and a diagnosis of chronic inflammatory demyelinating polyneuropathy (typical CIDP) was made according to established criteria. Our report expands on the possible outcomes in patients who develop Guillain–Barrè syndrome after COVID-19 vaccinations and suggest that close monitoring after the acute phase is needed in these patients to exclude a chronic evolution of the disease, which has important implications for long-term treatment. MDPI 2021-12-19 /pmc/articles/PMC8706382/ /pubmed/34960248 http://dx.doi.org/10.3390/vaccines9121502 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Bagella, Caterina Francesca Corda, Davide G. Zara, Pietro Elia, Antonio Emanuele Ruiu, Elisa Sechi, Elia Solla, Paolo Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination |
title | Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination |
title_full | Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination |
title_fullStr | Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination |
title_full_unstemmed | Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination |
title_short | Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination |
title_sort | chronic inflammatory demyelinating polyneuropathy after chadox1 ncov-19 vaccination |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706382/ https://www.ncbi.nlm.nih.gov/pubmed/34960248 http://dx.doi.org/10.3390/vaccines9121502 |
work_keys_str_mv | AT bagellacaterinafrancesca chronicinflammatorydemyelinatingpolyneuropathyafterchadox1ncov19vaccination AT cordadavideg chronicinflammatorydemyelinatingpolyneuropathyafterchadox1ncov19vaccination AT zarapietro chronicinflammatorydemyelinatingpolyneuropathyafterchadox1ncov19vaccination AT eliaantonioemanuele chronicinflammatorydemyelinatingpolyneuropathyafterchadox1ncov19vaccination AT ruiuelisa chronicinflammatorydemyelinatingpolyneuropathyafterchadox1ncov19vaccination AT sechielia chronicinflammatorydemyelinatingpolyneuropathyafterchadox1ncov19vaccination AT sollapaolo chronicinflammatorydemyelinatingpolyneuropathyafterchadox1ncov19vaccination |