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Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination

Recently several patients, who developed Guillain–Barré syndrome characterized by prominent bifacial weakness after ChAdOx1 nCoV-19 vaccination, were described from different centers. We recently observed a patient who developed a similar syndrome, later in the follow up he showed worsening of the n...

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Autores principales: Bagella, Caterina Francesca, Corda, Davide G., Zara, Pietro, Elia, Antonio Emanuele, Ruiu, Elisa, Sechi, Elia, Solla, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706382/
https://www.ncbi.nlm.nih.gov/pubmed/34960248
http://dx.doi.org/10.3390/vaccines9121502
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author Bagella, Caterina Francesca
Corda, Davide G.
Zara, Pietro
Elia, Antonio Emanuele
Ruiu, Elisa
Sechi, Elia
Solla, Paolo
author_facet Bagella, Caterina Francesca
Corda, Davide G.
Zara, Pietro
Elia, Antonio Emanuele
Ruiu, Elisa
Sechi, Elia
Solla, Paolo
author_sort Bagella, Caterina Francesca
collection PubMed
description Recently several patients, who developed Guillain–Barré syndrome characterized by prominent bifacial weakness after ChAdOx1 nCoV-19 vaccination, were described from different centers. We recently observed a patient who developed a similar syndrome, later in the follow up he showed worsening of the neuropathy two months after the initial presentation. Repeat EMG showed reduced nerve sensory and motor conduction velocities of both upper and lower limbs, and a diagnosis of chronic inflammatory demyelinating polyneuropathy (typical CIDP) was made according to established criteria. Our report expands on the possible outcomes in patients who develop Guillain–Barrè syndrome after COVID-19 vaccinations and suggest that close monitoring after the acute phase is needed in these patients to exclude a chronic evolution of the disease, which has important implications for long-term treatment.
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spelling pubmed-87063822021-12-25 Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination Bagella, Caterina Francesca Corda, Davide G. Zara, Pietro Elia, Antonio Emanuele Ruiu, Elisa Sechi, Elia Solla, Paolo Vaccines (Basel) Case Report Recently several patients, who developed Guillain–Barré syndrome characterized by prominent bifacial weakness after ChAdOx1 nCoV-19 vaccination, were described from different centers. We recently observed a patient who developed a similar syndrome, later in the follow up he showed worsening of the neuropathy two months after the initial presentation. Repeat EMG showed reduced nerve sensory and motor conduction velocities of both upper and lower limbs, and a diagnosis of chronic inflammatory demyelinating polyneuropathy (typical CIDP) was made according to established criteria. Our report expands on the possible outcomes in patients who develop Guillain–Barrè syndrome after COVID-19 vaccinations and suggest that close monitoring after the acute phase is needed in these patients to exclude a chronic evolution of the disease, which has important implications for long-term treatment. MDPI 2021-12-19 /pmc/articles/PMC8706382/ /pubmed/34960248 http://dx.doi.org/10.3390/vaccines9121502 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Bagella, Caterina Francesca
Corda, Davide G.
Zara, Pietro
Elia, Antonio Emanuele
Ruiu, Elisa
Sechi, Elia
Solla, Paolo
Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination
title Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination
title_full Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination
title_fullStr Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination
title_full_unstemmed Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination
title_short Chronic Inflammatory Demyelinating Polyneuropathy after ChAdOx1 nCoV-19 Vaccination
title_sort chronic inflammatory demyelinating polyneuropathy after chadox1 ncov-19 vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706382/
https://www.ncbi.nlm.nih.gov/pubmed/34960248
http://dx.doi.org/10.3390/vaccines9121502
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