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Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis
Background: Optimal heart rate (HR) that associates with higher cardiac output and greater clinical outcomes in patients with cardiac amyloidosis remains unknown. Methods: Consecutive patients with sinus rhythm who were diagnosed with cardiac amyloidosis at our institute between February 2015 and Fe...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706408/ https://www.ncbi.nlm.nih.gov/pubmed/34940536 http://dx.doi.org/10.3390/jcdd8120182 |
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author | Izumida, Toshihide Imamura, Teruhiko Nakamura, Makiko Kinugawa, Koichiro |
author_facet | Izumida, Toshihide Imamura, Teruhiko Nakamura, Makiko Kinugawa, Koichiro |
author_sort | Izumida, Toshihide |
collection | PubMed |
description | Background: Optimal heart rate (HR) that associates with higher cardiac output and greater clinical outcomes in patients with cardiac amyloidosis remains unknown. Methods: Consecutive patients with sinus rhythm who were diagnosed with cardiac amyloidosis at our institute between February 2015 and February 2021 were retrospectively included. Ideal HR, at which E-wave and A-wave stand adjacent without any overlaps in the trans-mitral flow echocardiography, was calculated by the formula: 86.8−0.08 × deceleration time (msec). The association between optimal HR and cardiac death or heart failure readmission was investigated. Results: Ten patients (median 74 years old, 8 men) were included. On median, actual HR was 64 bpm and ideal HR was 69 bpm. An incidence rate of the primary endpoint in the sub-optimal HR group tended to be higher than optimal HR group: one of the four patients in optimal HR group had events (25%); two of the two patients in higher HR group had events (100%); two of the four patients in lower HR group had events (50%). Conclusions: The optimal HR was associated with greater clinical outcomes in patients with cardiac amyloidosis. The clinical impact of aggressive HR optimization in this cohort remains the next concern. |
format | Online Article Text |
id | pubmed-8706408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87064082021-12-25 Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis Izumida, Toshihide Imamura, Teruhiko Nakamura, Makiko Kinugawa, Koichiro J Cardiovasc Dev Dis Article Background: Optimal heart rate (HR) that associates with higher cardiac output and greater clinical outcomes in patients with cardiac amyloidosis remains unknown. Methods: Consecutive patients with sinus rhythm who were diagnosed with cardiac amyloidosis at our institute between February 2015 and February 2021 were retrospectively included. Ideal HR, at which E-wave and A-wave stand adjacent without any overlaps in the trans-mitral flow echocardiography, was calculated by the formula: 86.8−0.08 × deceleration time (msec). The association between optimal HR and cardiac death or heart failure readmission was investigated. Results: Ten patients (median 74 years old, 8 men) were included. On median, actual HR was 64 bpm and ideal HR was 69 bpm. An incidence rate of the primary endpoint in the sub-optimal HR group tended to be higher than optimal HR group: one of the four patients in optimal HR group had events (25%); two of the two patients in higher HR group had events (100%); two of the four patients in lower HR group had events (50%). Conclusions: The optimal HR was associated with greater clinical outcomes in patients with cardiac amyloidosis. The clinical impact of aggressive HR optimization in this cohort remains the next concern. MDPI 2021-12-12 /pmc/articles/PMC8706408/ /pubmed/34940536 http://dx.doi.org/10.3390/jcdd8120182 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Izumida, Toshihide Imamura, Teruhiko Nakamura, Makiko Kinugawa, Koichiro Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis |
title | Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis |
title_full | Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis |
title_fullStr | Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis |
title_full_unstemmed | Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis |
title_short | Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis |
title_sort | optimal heart rate and prognosis in patients with cardiac amyloidosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706408/ https://www.ncbi.nlm.nih.gov/pubmed/34940536 http://dx.doi.org/10.3390/jcdd8120182 |
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