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Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis

Background: Optimal heart rate (HR) that associates with higher cardiac output and greater clinical outcomes in patients with cardiac amyloidosis remains unknown. Methods: Consecutive patients with sinus rhythm who were diagnosed with cardiac amyloidosis at our institute between February 2015 and Fe...

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Autores principales: Izumida, Toshihide, Imamura, Teruhiko, Nakamura, Makiko, Kinugawa, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706408/
https://www.ncbi.nlm.nih.gov/pubmed/34940536
http://dx.doi.org/10.3390/jcdd8120182
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author Izumida, Toshihide
Imamura, Teruhiko
Nakamura, Makiko
Kinugawa, Koichiro
author_facet Izumida, Toshihide
Imamura, Teruhiko
Nakamura, Makiko
Kinugawa, Koichiro
author_sort Izumida, Toshihide
collection PubMed
description Background: Optimal heart rate (HR) that associates with higher cardiac output and greater clinical outcomes in patients with cardiac amyloidosis remains unknown. Methods: Consecutive patients with sinus rhythm who were diagnosed with cardiac amyloidosis at our institute between February 2015 and February 2021 were retrospectively included. Ideal HR, at which E-wave and A-wave stand adjacent without any overlaps in the trans-mitral flow echocardiography, was calculated by the formula: 86.8−0.08 × deceleration time (msec). The association between optimal HR and cardiac death or heart failure readmission was investigated. Results: Ten patients (median 74 years old, 8 men) were included. On median, actual HR was 64 bpm and ideal HR was 69 bpm. An incidence rate of the primary endpoint in the sub-optimal HR group tended to be higher than optimal HR group: one of the four patients in optimal HR group had events (25%); two of the two patients in higher HR group had events (100%); two of the four patients in lower HR group had events (50%). Conclusions: The optimal HR was associated with greater clinical outcomes in patients with cardiac amyloidosis. The clinical impact of aggressive HR optimization in this cohort remains the next concern.
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spelling pubmed-87064082021-12-25 Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis Izumida, Toshihide Imamura, Teruhiko Nakamura, Makiko Kinugawa, Koichiro J Cardiovasc Dev Dis Article Background: Optimal heart rate (HR) that associates with higher cardiac output and greater clinical outcomes in patients with cardiac amyloidosis remains unknown. Methods: Consecutive patients with sinus rhythm who were diagnosed with cardiac amyloidosis at our institute between February 2015 and February 2021 were retrospectively included. Ideal HR, at which E-wave and A-wave stand adjacent without any overlaps in the trans-mitral flow echocardiography, was calculated by the formula: 86.8−0.08 × deceleration time (msec). The association between optimal HR and cardiac death or heart failure readmission was investigated. Results: Ten patients (median 74 years old, 8 men) were included. On median, actual HR was 64 bpm and ideal HR was 69 bpm. An incidence rate of the primary endpoint in the sub-optimal HR group tended to be higher than optimal HR group: one of the four patients in optimal HR group had events (25%); two of the two patients in higher HR group had events (100%); two of the four patients in lower HR group had events (50%). Conclusions: The optimal HR was associated with greater clinical outcomes in patients with cardiac amyloidosis. The clinical impact of aggressive HR optimization in this cohort remains the next concern. MDPI 2021-12-12 /pmc/articles/PMC8706408/ /pubmed/34940536 http://dx.doi.org/10.3390/jcdd8120182 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Izumida, Toshihide
Imamura, Teruhiko
Nakamura, Makiko
Kinugawa, Koichiro
Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis
title Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis
title_full Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis
title_fullStr Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis
title_full_unstemmed Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis
title_short Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis
title_sort optimal heart rate and prognosis in patients with cardiac amyloidosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706408/
https://www.ncbi.nlm.nih.gov/pubmed/34940536
http://dx.doi.org/10.3390/jcdd8120182
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