Cargando…

Influence of Polyunsaturated Fatty Acid Intake on Kidney Functions of Rats with Chronic Renal Failure

Arachidonic acid (ARA), an omega-6 (ω-6) polyunsaturated fatty acid (PUFA), is involved in the development and maintenance of renal functions, whereas docosahexaenoic acid (DHA) is an omega-3 (ω-3) PUFA that has anti-inflammatory effects and attenuates nephropathy. However, their effects on the prog...

Descripción completa

Detalles Bibliográficos
Autores principales: Muramatsu, Hiroki, Akimoto, Naoe, Hashimoto, Michio, Sugibayashi, Kenji, Katakura, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706431/
https://www.ncbi.nlm.nih.gov/pubmed/34940691
http://dx.doi.org/10.3390/md19120692
_version_ 1784622190814035968
author Muramatsu, Hiroki
Akimoto, Naoe
Hashimoto, Michio
Sugibayashi, Kenji
Katakura, Masanori
author_facet Muramatsu, Hiroki
Akimoto, Naoe
Hashimoto, Michio
Sugibayashi, Kenji
Katakura, Masanori
author_sort Muramatsu, Hiroki
collection PubMed
description Arachidonic acid (ARA), an omega-6 (ω-6) polyunsaturated fatty acid (PUFA), is involved in the development and maintenance of renal functions, whereas docosahexaenoic acid (DHA) is an omega-3 (ω-3) PUFA that has anti-inflammatory effects and attenuates nephropathy. However, their effects on the progression of chronic kidney disease (CKD) remain unknown. The aim of this study was to assess the effects of feeding ARA, DHA, and ARA and DHA-containing diets on rats with 5/6 nephrectomized kidneys. Urine and feces were collected every 4 weeks, and the kidneys were collected at 16 weeks after surgery. Urinary albumin (U-ALB) excretion increased gradually with nephrectomy, but the U-ALB excretion was attenuated by feeding the rats with an ARA + DHA-containing diet. Reactive oxygen species (ROS) levels in the kidneys were lower in the ARA + DHA group than in the other groups. At 4 weeks after surgery, the lipid peroxide (LPO) levels in the plasma of the ARA + DHA groups decreased significantly after surgery compared to the control CKD group, but this did not happen at 16 weeks post-surgery. There was a significant negative correlation between LPO levels in the plasma at 4 weeks and creatinine clearance, and a positive correlation with urinary albumin levels. These results suggest that the combination of ARA and DHA inhibit the progress of early stage CKD.
format Online
Article
Text
id pubmed-8706431
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87064312021-12-25 Influence of Polyunsaturated Fatty Acid Intake on Kidney Functions of Rats with Chronic Renal Failure Muramatsu, Hiroki Akimoto, Naoe Hashimoto, Michio Sugibayashi, Kenji Katakura, Masanori Mar Drugs Article Arachidonic acid (ARA), an omega-6 (ω-6) polyunsaturated fatty acid (PUFA), is involved in the development and maintenance of renal functions, whereas docosahexaenoic acid (DHA) is an omega-3 (ω-3) PUFA that has anti-inflammatory effects and attenuates nephropathy. However, their effects on the progression of chronic kidney disease (CKD) remain unknown. The aim of this study was to assess the effects of feeding ARA, DHA, and ARA and DHA-containing diets on rats with 5/6 nephrectomized kidneys. Urine and feces were collected every 4 weeks, and the kidneys were collected at 16 weeks after surgery. Urinary albumin (U-ALB) excretion increased gradually with nephrectomy, but the U-ALB excretion was attenuated by feeding the rats with an ARA + DHA-containing diet. Reactive oxygen species (ROS) levels in the kidneys were lower in the ARA + DHA group than in the other groups. At 4 weeks after surgery, the lipid peroxide (LPO) levels in the plasma of the ARA + DHA groups decreased significantly after surgery compared to the control CKD group, but this did not happen at 16 weeks post-surgery. There was a significant negative correlation between LPO levels in the plasma at 4 weeks and creatinine clearance, and a positive correlation with urinary albumin levels. These results suggest that the combination of ARA and DHA inhibit the progress of early stage CKD. MDPI 2021-12-03 /pmc/articles/PMC8706431/ /pubmed/34940691 http://dx.doi.org/10.3390/md19120692 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Muramatsu, Hiroki
Akimoto, Naoe
Hashimoto, Michio
Sugibayashi, Kenji
Katakura, Masanori
Influence of Polyunsaturated Fatty Acid Intake on Kidney Functions of Rats with Chronic Renal Failure
title Influence of Polyunsaturated Fatty Acid Intake on Kidney Functions of Rats with Chronic Renal Failure
title_full Influence of Polyunsaturated Fatty Acid Intake on Kidney Functions of Rats with Chronic Renal Failure
title_fullStr Influence of Polyunsaturated Fatty Acid Intake on Kidney Functions of Rats with Chronic Renal Failure
title_full_unstemmed Influence of Polyunsaturated Fatty Acid Intake on Kidney Functions of Rats with Chronic Renal Failure
title_short Influence of Polyunsaturated Fatty Acid Intake on Kidney Functions of Rats with Chronic Renal Failure
title_sort influence of polyunsaturated fatty acid intake on kidney functions of rats with chronic renal failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706431/
https://www.ncbi.nlm.nih.gov/pubmed/34940691
http://dx.doi.org/10.3390/md19120692
work_keys_str_mv AT muramatsuhiroki influenceofpolyunsaturatedfattyacidintakeonkidneyfunctionsofratswithchronicrenalfailure
AT akimotonaoe influenceofpolyunsaturatedfattyacidintakeonkidneyfunctionsofratswithchronicrenalfailure
AT hashimotomichio influenceofpolyunsaturatedfattyacidintakeonkidneyfunctionsofratswithchronicrenalfailure
AT sugibayashikenji influenceofpolyunsaturatedfattyacidintakeonkidneyfunctionsofratswithchronicrenalfailure
AT katakuramasanori influenceofpolyunsaturatedfattyacidintakeonkidneyfunctionsofratswithchronicrenalfailure