Two-Photon Time-Gated In Vivo Imaging of Dihydrolipoic-Acid-Decorated Gold Nanoclusters

Due to the unique advantages of two-photon technology and time-resolved imaging technology in the biomedical field, attention has been paid to them. Gold clusters possess excellent physicochemical properties and low biotoxicity, which make them greatly advantageous in biological imaging, especially...

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Detalles Bibliográficos
Autores principales: Tian, Ye, Wei, Ming, Wang, Lijun, Hong, Yuankai, Luo, Dan, Sha, Yinlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706569/
https://www.ncbi.nlm.nih.gov/pubmed/34947339
http://dx.doi.org/10.3390/ma14247744
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author Tian, Ye
Wei, Ming
Wang, Lijun
Hong, Yuankai
Luo, Dan
Sha, Yinlin
author_facet Tian, Ye
Wei, Ming
Wang, Lijun
Hong, Yuankai
Luo, Dan
Sha, Yinlin
author_sort Tian, Ye
collection PubMed
description Due to the unique advantages of two-photon technology and time-resolved imaging technology in the biomedical field, attention has been paid to them. Gold clusters possess excellent physicochemical properties and low biotoxicity, which make them greatly advantageous in biological imaging, especially for in vivo animal imaging. A gold nanocluster was coupled with dihydrolipoic acid to obtain a functionalized nanoprobe; the material displayed significant features, including a large two-photon absorption cross-section (up to 1.59 × 10(5) GM) and prolonged fluorescence lifetime (>300 ns). The two-photon and time-resolution techniques were used to perform cell imaging and in vivo imaging.
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spelling pubmed-87065692021-12-25 Two-Photon Time-Gated In Vivo Imaging of Dihydrolipoic-Acid-Decorated Gold Nanoclusters Tian, Ye Wei, Ming Wang, Lijun Hong, Yuankai Luo, Dan Sha, Yinlin Materials (Basel) Article Due to the unique advantages of two-photon technology and time-resolved imaging technology in the biomedical field, attention has been paid to them. Gold clusters possess excellent physicochemical properties and low biotoxicity, which make them greatly advantageous in biological imaging, especially for in vivo animal imaging. A gold nanocluster was coupled with dihydrolipoic acid to obtain a functionalized nanoprobe; the material displayed significant features, including a large two-photon absorption cross-section (up to 1.59 × 10(5) GM) and prolonged fluorescence lifetime (>300 ns). The two-photon and time-resolution techniques were used to perform cell imaging and in vivo imaging. MDPI 2021-12-15 /pmc/articles/PMC8706569/ /pubmed/34947339 http://dx.doi.org/10.3390/ma14247744 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tian, Ye
Wei, Ming
Wang, Lijun
Hong, Yuankai
Luo, Dan
Sha, Yinlin
Two-Photon Time-Gated In Vivo Imaging of Dihydrolipoic-Acid-Decorated Gold Nanoclusters
title Two-Photon Time-Gated In Vivo Imaging of Dihydrolipoic-Acid-Decorated Gold Nanoclusters
title_full Two-Photon Time-Gated In Vivo Imaging of Dihydrolipoic-Acid-Decorated Gold Nanoclusters
title_fullStr Two-Photon Time-Gated In Vivo Imaging of Dihydrolipoic-Acid-Decorated Gold Nanoclusters
title_full_unstemmed Two-Photon Time-Gated In Vivo Imaging of Dihydrolipoic-Acid-Decorated Gold Nanoclusters
title_short Two-Photon Time-Gated In Vivo Imaging of Dihydrolipoic-Acid-Decorated Gold Nanoclusters
title_sort two-photon time-gated in vivo imaging of dihydrolipoic-acid-decorated gold nanoclusters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706569/
https://www.ncbi.nlm.nih.gov/pubmed/34947339
http://dx.doi.org/10.3390/ma14247744
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