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The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy

It is known that the initiation of photodynamic therapy (PDT) in deep-seated tumors requires the use of X-rays to activate the reactive oxygen species generation in deep tissues. The aim of this paper is to synthesize X-ray nanophosphors and analyze their structural and luminescence characteristics...

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Autores principales: Kirsanova, Daria, Polyakov, Vladimir, Butova, Vera, Zolotukhin, Peter, Belanova, Anna, Gadzhimagomedova, Zaira, Soldatov, Mikhail, Pankin, Ilia, Soldatov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706573/
https://www.ncbi.nlm.nih.gov/pubmed/34947560
http://dx.doi.org/10.3390/nano11123212
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author Kirsanova, Daria
Polyakov, Vladimir
Butova, Vera
Zolotukhin, Peter
Belanova, Anna
Gadzhimagomedova, Zaira
Soldatov, Mikhail
Pankin, Ilia
Soldatov, Alexander
author_facet Kirsanova, Daria
Polyakov, Vladimir
Butova, Vera
Zolotukhin, Peter
Belanova, Anna
Gadzhimagomedova, Zaira
Soldatov, Mikhail
Pankin, Ilia
Soldatov, Alexander
author_sort Kirsanova, Daria
collection PubMed
description It is known that the initiation of photodynamic therapy (PDT) in deep-seated tumors requires the use of X-rays to activate the reactive oxygen species generation in deep tissues. The aim of this paper is to synthesize X-ray nanophosphors and analyze their structural and luminescence characteristics to push the PDT process deep into the body. The article deals with BaGdF(5):Eu(3+), BaGdF(5):Sm(3+), and BaGdF(5):Tb(3+) nanophosphors synthesized using microwave synthesis. It is found that the nanoparticles are biocompatible and have sizes 5–17 nm. However, according to the analysis of X-ray excited optical luminescence, BaGdF(5):Sm(3+) nanophosphors will not be effective for treating deep-seated tumors. Thus, BaGdF(5):Eu(3+) and BaGdF(5):Tb(3+) nanoparticles meet the requirements for the subsequent production of nanocomposites based on them that can be used in X-ray photodynamic therapy.
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spelling pubmed-87065732021-12-25 The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy Kirsanova, Daria Polyakov, Vladimir Butova, Vera Zolotukhin, Peter Belanova, Anna Gadzhimagomedova, Zaira Soldatov, Mikhail Pankin, Ilia Soldatov, Alexander Nanomaterials (Basel) Article It is known that the initiation of photodynamic therapy (PDT) in deep-seated tumors requires the use of X-rays to activate the reactive oxygen species generation in deep tissues. The aim of this paper is to synthesize X-ray nanophosphors and analyze their structural and luminescence characteristics to push the PDT process deep into the body. The article deals with BaGdF(5):Eu(3+), BaGdF(5):Sm(3+), and BaGdF(5):Tb(3+) nanophosphors synthesized using microwave synthesis. It is found that the nanoparticles are biocompatible and have sizes 5–17 nm. However, according to the analysis of X-ray excited optical luminescence, BaGdF(5):Sm(3+) nanophosphors will not be effective for treating deep-seated tumors. Thus, BaGdF(5):Eu(3+) and BaGdF(5):Tb(3+) nanoparticles meet the requirements for the subsequent production of nanocomposites based on them that can be used in X-ray photodynamic therapy. MDPI 2021-11-26 /pmc/articles/PMC8706573/ /pubmed/34947560 http://dx.doi.org/10.3390/nano11123212 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kirsanova, Daria
Polyakov, Vladimir
Butova, Vera
Zolotukhin, Peter
Belanova, Anna
Gadzhimagomedova, Zaira
Soldatov, Mikhail
Pankin, Ilia
Soldatov, Alexander
The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy
title The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy
title_full The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy
title_fullStr The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy
title_full_unstemmed The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy
title_short The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy
title_sort rare-earth elements doping of bagdf(5) nanophosphors for x-ray photodynamic therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706573/
https://www.ncbi.nlm.nih.gov/pubmed/34947560
http://dx.doi.org/10.3390/nano11123212
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