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The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy
It is known that the initiation of photodynamic therapy (PDT) in deep-seated tumors requires the use of X-rays to activate the reactive oxygen species generation in deep tissues. The aim of this paper is to synthesize X-ray nanophosphors and analyze their structural and luminescence characteristics...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706573/ https://www.ncbi.nlm.nih.gov/pubmed/34947560 http://dx.doi.org/10.3390/nano11123212 |
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author | Kirsanova, Daria Polyakov, Vladimir Butova, Vera Zolotukhin, Peter Belanova, Anna Gadzhimagomedova, Zaira Soldatov, Mikhail Pankin, Ilia Soldatov, Alexander |
author_facet | Kirsanova, Daria Polyakov, Vladimir Butova, Vera Zolotukhin, Peter Belanova, Anna Gadzhimagomedova, Zaira Soldatov, Mikhail Pankin, Ilia Soldatov, Alexander |
author_sort | Kirsanova, Daria |
collection | PubMed |
description | It is known that the initiation of photodynamic therapy (PDT) in deep-seated tumors requires the use of X-rays to activate the reactive oxygen species generation in deep tissues. The aim of this paper is to synthesize X-ray nanophosphors and analyze their structural and luminescence characteristics to push the PDT process deep into the body. The article deals with BaGdF(5):Eu(3+), BaGdF(5):Sm(3+), and BaGdF(5):Tb(3+) nanophosphors synthesized using microwave synthesis. It is found that the nanoparticles are biocompatible and have sizes 5–17 nm. However, according to the analysis of X-ray excited optical luminescence, BaGdF(5):Sm(3+) nanophosphors will not be effective for treating deep-seated tumors. Thus, BaGdF(5):Eu(3+) and BaGdF(5):Tb(3+) nanoparticles meet the requirements for the subsequent production of nanocomposites based on them that can be used in X-ray photodynamic therapy. |
format | Online Article Text |
id | pubmed-8706573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87065732021-12-25 The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy Kirsanova, Daria Polyakov, Vladimir Butova, Vera Zolotukhin, Peter Belanova, Anna Gadzhimagomedova, Zaira Soldatov, Mikhail Pankin, Ilia Soldatov, Alexander Nanomaterials (Basel) Article It is known that the initiation of photodynamic therapy (PDT) in deep-seated tumors requires the use of X-rays to activate the reactive oxygen species generation in deep tissues. The aim of this paper is to synthesize X-ray nanophosphors and analyze their structural and luminescence characteristics to push the PDT process deep into the body. The article deals with BaGdF(5):Eu(3+), BaGdF(5):Sm(3+), and BaGdF(5):Tb(3+) nanophosphors synthesized using microwave synthesis. It is found that the nanoparticles are biocompatible and have sizes 5–17 nm. However, according to the analysis of X-ray excited optical luminescence, BaGdF(5):Sm(3+) nanophosphors will not be effective for treating deep-seated tumors. Thus, BaGdF(5):Eu(3+) and BaGdF(5):Tb(3+) nanoparticles meet the requirements for the subsequent production of nanocomposites based on them that can be used in X-ray photodynamic therapy. MDPI 2021-11-26 /pmc/articles/PMC8706573/ /pubmed/34947560 http://dx.doi.org/10.3390/nano11123212 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kirsanova, Daria Polyakov, Vladimir Butova, Vera Zolotukhin, Peter Belanova, Anna Gadzhimagomedova, Zaira Soldatov, Mikhail Pankin, Ilia Soldatov, Alexander The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy |
title | The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy |
title_full | The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy |
title_fullStr | The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy |
title_full_unstemmed | The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy |
title_short | The Rare-Earth Elements Doping of BaGdF(5) Nanophosphors for X-ray Photodynamic Therapy |
title_sort | rare-earth elements doping of bagdf(5) nanophosphors for x-ray photodynamic therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706573/ https://www.ncbi.nlm.nih.gov/pubmed/34947560 http://dx.doi.org/10.3390/nano11123212 |
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