HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection

Leishmanial skin lesions are characterized by inflammatory hypoxia alongside the activation of hypoxia-inducible factors, HIF-1α and HIF-2α, and subsequent expression of the HIF-α target VEGF-A during Leishmania major infection. However, the factors responsible for HIF-α activation are not known. We...

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Detalles Bibliográficos
Autores principales: Bettadapura, Manjunath, Roys, Hayden, Bowlin, Anne, Venugopal, Gopinath, Washam, Charity L., Fry, Lucy, Murdock, Steven, Wanjala, Humphrey, Byrum, Stephanie D., Weinkopff, Tiffany
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706659/
https://www.ncbi.nlm.nih.gov/pubmed/34959539
http://dx.doi.org/10.3390/pathogens10121584

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