Targeting AKT in ER-Positive HER2-Negative Metastatic Breast Cancer: From Molecular Promises to Real Life Pitfalls?

The AKT protein kinase plays a central role in several interconnected molecular pathways involved in growth, apoptosis, angiogenesis, and cell metabolism. It thereby represents a therapeutic target, especially in hormone receptor-positive (HR) breast cancers, where the PI3K/AKT signaling pathway is...

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Detalles Bibliográficos
Autores principales: Mery, Benoîte, Poulard, Coralie, Le Romancer, Muriel, Trédan, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706716/
https://www.ncbi.nlm.nih.gov/pubmed/34948307
http://dx.doi.org/10.3390/ijms222413512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706716/
https://www.ncbi.nlm.nih.gov/pubmed/34948307
http://dx.doi.org/10.3390/ijms222413512

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