Cargando…

Targeting AKT in ER-Positive HER2-Negative Metastatic Breast Cancer: From Molecular Promises to Real Life Pitfalls?

The AKT protein kinase plays a central role in several interconnected molecular pathways involved in growth, apoptosis, angiogenesis, and cell metabolism. It thereby represents a therapeutic target, especially in hormone receptor-positive (HR) breast cancers, where the PI3K/AKT signaling pathway is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mery, Benoîte, Poulard, Coralie, Le Romancer, Muriel, Trédan, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706716/ https://www.ncbi.nlm.nih.gov/pubmed/34948307 http://dx.doi.org/10.3390/ijms222413512

Ejemplares similares

Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα (+) breast cancer
por: Poulard, Coralie, et al.
Publicado: (2023)

Glucocorticoid Receptor: A Multifaceted Actor in Breast Cancer
por: Noureddine, Lara Malik, et al.
Publicado: (2021)

ERα-36 regulates progesterone receptor activity in breast cancer
por: Konan, Henri-Philippe, et al.
Publicado: (2020)

JMJD6 Regulates ERα Methylation on Arginine
por: Poulard, Coralie, et al.
Publicado: (2014)

PRMT5 prognostic value in cancer
por: Lattouf, Hanine, et al.
Publicado: (2019)

Protein arginine methylation/demethylation and cancer
por: Poulard, Coralie, et al.
Publicado: (2016)

Activation of rapid oestrogen signalling in aggressive human breast cancers
por: Poulard, Coralie, et al.
Publicado: (2012)

Oestrogen Non-Genomic Signalling is Activated in Tamoxifen-Resistant Breast Cancer
por: Poulard, Coralie, et al.
Publicado: (2019)

PRMT5 triggers glucocorticoid-induced cell migration in triple-negative breast cancer
por: Noureddine, Lara Malik, et al.
Publicado: (2023)

Role of JMJD6 in Breast Tumourigenesis
por: Poulard, Coralie, et al.
Publicado: (2015)

Structure, Activity, and Function of PRMT1
por: Thiebaut, Charlène, et al.
Publicado: (2021)

Structure, Activity, and Function of the Protein Lysine Methyltransferase G9a
por: Poulard, Coralie, et al.
Publicado: (2021)

PRMT1, a Key Modulator of Unliganded Progesterone Receptor Signaling in Breast Cancer
por: Malbeteau, Lucie, et al.
Publicado: (2022)

PRMT1 Is Critical for the Transcriptional Activity and the Stability of the Progesterone Receptor
por: Malbeteau, Lucie, et al.
Publicado: (2020)

How Protein Methylation Regulates Steroid Receptor Function
por: Malbeteau, Lucie, et al.
Publicado: (2021)

Reduced menin expression leads to decreased ERα expression and is correlated with the occurrence of human luminal B-like and ER-negative breast cancer subtypes
por: Teinturier, Romain, et al.
Publicado: (2021)

Promise and pitfalls of the Immunochip
por: Cortes, Adrian, et al.
Publicado: (2011)

The Promise and Pitfalls of Prophages
por: McKerral, Jody C., et al.
Publicado: (2023)

The Role of ERα36 in Development and Tumor Malignancy
por: Thiebaut, Charlène, et al.
Publicado: (2020)

A Digital Solution for an Advanced Breast Tumor Board: Pilot Application Cocreation and Implementation Study
por: Hodroj, Khalil, et al.
Publicado: (2023)

Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation
por: Redmond, Aisling M., et al.
Publicado: (2019)

Eribulin monotherapy improved survivals in patients with ER-positive HER2-negative metastatic breast cancer in the real world: a single institutional review
por: Watanabe, Junichiro
Publicado: (2015)

Targeted therapies for ER+/HER2- metastatic breast cancer
por: Yamamoto-Ibusuki, Mutsuko, et al.
Publicado: (2015)

COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer
por: Glynn, Sharon A, et al.
Publicado: (2010)

The molecular mechanisms underlying the ERα-36-mediated signaling in breast cancer
por: Omarjee, S, et al.
Publicado: (2017)

DNA Barcoding: Promise and Pitfalls
por: Moritz, Craig, et al.
Publicado: (2004)

Personalized Medicine: Promises and Pitfalls
por: Huang, Jean
Publicado: (2017)

Prognostic Impact of HER2 and ER Status of Circulating Tumor Cells in Metastatic Breast Cancer Patients with a HER2-Negative Primary Tumor()
por: Beije, Nick, et al.
Publicado: (2016)

PRMT1 Regulates EGFR and Wnt Signaling Pathways and Is a Promising Target for Combinatorial Treatment of Breast Cancer
por: Suresh, Samyuktha, et al.
Publicado: (2022)

The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer
por: Choucair, Ali, et al.
Publicado: (2019)

Promise and Pitfalls of Animal Models of Schizophrenia
por: Feifel, David, et al.
Publicado: (2010)

Promises and Pitfalls of Intracellular Delivery of Proteins
por: Fu, Ailing, et al.
Publicado: (2014)

Nuclear worker studies: promise and pitfalls
por: Wakeford, R
Publicado: (2014)

The Genetics of Sepsis: The Promise, the Progress and the Pitfalls
por: Waterer, Grant W.
Publicado: (2008)

Dissociation and Brain Rhythms: Pitfalls and Promises
por: Grent-'t-Jong, Tineke, et al.
Publicado: (2021)

Pembrolizumab in Lymphopenic Metastatic Breast Cancer Patients Treated with Metronomic Cyclophosphamide: A Clinical and Translational Prospective Study
por: Mery, Benoîte, et al.
Publicado: (2023)

Baseline Mutations and ctDNA Dynamics as Prognostic and Predictive Factors in ER-Positive/HER2-Negative Metastatic Breast Cancer Patients
por: Pascual, Javier, et al.
Publicado: (2023)

TP53 Mutation as a Prognostic and Predictive Marker in Sarcoma: Pooled Analysis of MOSCATO and ProfiLER Precision Medicine Trials
por: Nassif, Elise F., et al.
Publicado: (2021)

Treatment patterns and real world clinical outcomes in ER+/HER2- post-menopausal metastatic breast cancer patients in the United States
por: Zanotti, Giovanni, et al.
Publicado: (2017)

Managing metastatic renal cell carcinoma-challenges, pitfalls, and outcomes in the real world
por: Kumar, Karnam Ashok, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_r2th407qvnko76uclhn3k4pgvi