Cargando…

Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report

Background and objective: Coronary artery disease is one of the leading causes of deaths nowadays and the trends in diagnosis and revascularization are still in plateau despite well-known factors. Simple whole blood count parameters may be used to measure inflammatory reactions that are involved in...

Descripción completa

Detalles Bibliográficos
Autores principales: Urbanowicz, Tomasz, Michalak, Michał, Olasińska-Wiśniewska, Anna, Witkowska, Anna, Rodzki, Michał, Błażejowska, Ewelina, Gąsecka, Aleksandra, Perek, Bartłomiej, Jemielity, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706717/
https://www.ncbi.nlm.nih.gov/pubmed/34946269
http://dx.doi.org/10.3390/medicina57121324
_version_ 1784622261107425280
author Urbanowicz, Tomasz
Michalak, Michał
Olasińska-Wiśniewska, Anna
Witkowska, Anna
Rodzki, Michał
Błażejowska, Ewelina
Gąsecka, Aleksandra
Perek, Bartłomiej
Jemielity, Marek
author_facet Urbanowicz, Tomasz
Michalak, Michał
Olasińska-Wiśniewska, Anna
Witkowska, Anna
Rodzki, Michał
Błażejowska, Ewelina
Gąsecka, Aleksandra
Perek, Bartłomiej
Jemielity, Marek
author_sort Urbanowicz, Tomasz
collection PubMed
description Background and objective: Coronary artery disease is one of the leading causes of deaths nowadays and the trends in diagnosis and revascularization are still in plateau despite well-known factors. Simple whole blood count parameters may be used to measure inflammatory reactions that are involved in processes of atherosclerosis progression. The aim of our study was to analyse the association between simply available hematologic indices and long-term mortality following off-pump coronary artery bypass grafting (OPCAB). Material and Methods: The study group comprised 129 consecutive patients (16 females and 113 males, mean age 66 ± 6 years) who underwent surgical revascularization with off-pump technique between January 2014 and September 2019. The mean follow-up was 4.7 +/−1.9 years. A receiver operating characteristics curve was applied to estimate demographical and perioperative parameters including MLR for mortality. Results: Cox regression analysis revealed chronic pulmonary obstructive disease (HR = 2.86, 95%CI 1.05–7.78), MLR (HR = 3.81, 95%CI 1.45–10.06) and right coronary artery blood flow (HR = 1.06, 95%CI 1.00–1.10) as significant factors predicting increased mortality risk. In the presented model, the MLR > 1.44 on 1st postoperative day was a significant predictor of late mortality after the OPCAB procedure (HR = 3.82, 95%CI 1.45–10.06). Conclusions: Pronounced inflammatory reaction after off-pump surgery measured by MLR > 1.44 can be regarded as a worse long-term prognostic factor.
format Online
Article
Text
id pubmed-8706717
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87067172021-12-25 Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report Urbanowicz, Tomasz Michalak, Michał Olasińska-Wiśniewska, Anna Witkowska, Anna Rodzki, Michał Błażejowska, Ewelina Gąsecka, Aleksandra Perek, Bartłomiej Jemielity, Marek Medicina (Kaunas) Article Background and objective: Coronary artery disease is one of the leading causes of deaths nowadays and the trends in diagnosis and revascularization are still in plateau despite well-known factors. Simple whole blood count parameters may be used to measure inflammatory reactions that are involved in processes of atherosclerosis progression. The aim of our study was to analyse the association between simply available hematologic indices and long-term mortality following off-pump coronary artery bypass grafting (OPCAB). Material and Methods: The study group comprised 129 consecutive patients (16 females and 113 males, mean age 66 ± 6 years) who underwent surgical revascularization with off-pump technique between January 2014 and September 2019. The mean follow-up was 4.7 +/−1.9 years. A receiver operating characteristics curve was applied to estimate demographical and perioperative parameters including MLR for mortality. Results: Cox regression analysis revealed chronic pulmonary obstructive disease (HR = 2.86, 95%CI 1.05–7.78), MLR (HR = 3.81, 95%CI 1.45–10.06) and right coronary artery blood flow (HR = 1.06, 95%CI 1.00–1.10) as significant factors predicting increased mortality risk. In the presented model, the MLR > 1.44 on 1st postoperative day was a significant predictor of late mortality after the OPCAB procedure (HR = 3.82, 95%CI 1.45–10.06). Conclusions: Pronounced inflammatory reaction after off-pump surgery measured by MLR > 1.44 can be regarded as a worse long-term prognostic factor. MDPI 2021-12-03 /pmc/articles/PMC8706717/ /pubmed/34946269 http://dx.doi.org/10.3390/medicina57121324 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Urbanowicz, Tomasz
Michalak, Michał
Olasińska-Wiśniewska, Anna
Witkowska, Anna
Rodzki, Michał
Błażejowska, Ewelina
Gąsecka, Aleksandra
Perek, Bartłomiej
Jemielity, Marek
Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report
title Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report
title_full Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report
title_fullStr Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report
title_full_unstemmed Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report
title_short Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report
title_sort monocyte-to-lymphocyte ratio as a predictor of worse long-term survival after off-pump surgical revascularization-initial report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706717/
https://www.ncbi.nlm.nih.gov/pubmed/34946269
http://dx.doi.org/10.3390/medicina57121324
work_keys_str_mv AT urbanowicztomasz monocytetolymphocyteratioasapredictorofworselongtermsurvivalafteroffpumpsurgicalrevascularizationinitialreport
AT michalakmichał monocytetolymphocyteratioasapredictorofworselongtermsurvivalafteroffpumpsurgicalrevascularizationinitialreport
AT olasinskawisniewskaanna monocytetolymphocyteratioasapredictorofworselongtermsurvivalafteroffpumpsurgicalrevascularizationinitialreport
AT witkowskaanna monocytetolymphocyteratioasapredictorofworselongtermsurvivalafteroffpumpsurgicalrevascularizationinitialreport
AT rodzkimichał monocytetolymphocyteratioasapredictorofworselongtermsurvivalafteroffpumpsurgicalrevascularizationinitialreport
AT błazejowskaewelina monocytetolymphocyteratioasapredictorofworselongtermsurvivalafteroffpumpsurgicalrevascularizationinitialreport
AT gaseckaaleksandra monocytetolymphocyteratioasapredictorofworselongtermsurvivalafteroffpumpsurgicalrevascularizationinitialreport
AT perekbartłomiej monocytetolymphocyteratioasapredictorofworselongtermsurvivalafteroffpumpsurgicalrevascularizationinitialreport
AT jemielitymarek monocytetolymphocyteratioasapredictorofworselongtermsurvivalafteroffpumpsurgicalrevascularizationinitialreport