Beyond proteins: Ubiquitylation of lipopolysaccharide to fight bacteria

Mechanisms and functions of protein ubiquitylation and LPS ubiquitylation. LPS ubiquitylation serves as a scaffold to recruit E3 ligases for the ubiquitylation of the membrane of bacteria. Polyubiquitin coat on the bacterial cell surface is one type of “eat‐me” signal recognized by the host cells. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Gong, Yanqiu, Nie, Litong, Dai, Lunzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Highlights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706746/
https://www.ncbi.nlm.nih.gov/pubmed/34977880
http://dx.doi.org/10.1002/mco2.86
Descripción
Sumario:Mechanisms and functions of protein ubiquitylation and LPS ubiquitylation. LPS ubiquitylation serves as a scaffold to recruit E3 ligases for the ubiquitylation of the membrane of bacteria. Polyubiquitin coat on the bacterial cell surface is one type of “eat‐me” signal recognized by the host cells. The abbreviations used in the figure are Pro, Protein; Ub, Ubiquitin; E1, Ubiquitin‐activating enzymes; E2, Ubiquitin‐conjugating enzymes; E3, Ubiquitin‐ligating enzymes; LPS, lipopolysaccharide; RNF213, Ring Finger Protein 213; and LUBAC, linear ubiquitin chain assembly complex. [Image: see text]

Ejemplares similares