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Overcoming multidrug resistance by knockout of ABCB1 gene using CRISPR/Cas9 system in SW620/Ad300 colorectal cancer cells

Multidrug resistance (MDR) has been extensively reported in colorectal cancer patients, which remains a major cause of chemotherapy failure. One of the critical mechanisms of MDR in colorectal cancer is the reduced intracellular drug level led by the upregulated expression of the ATP‐binding cassett...

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Detalles Bibliográficos
Autores principales:	Lei, Zi‐Ning, Teng, Qiu‐Xu, Wu, Zhuo‐Xun, Ping, Feng‐Feng, Song, Peng, Wurpel, John N.D., Chen, Zhe‐Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706751/ https://www.ncbi.nlm.nih.gov/pubmed/34977876 http://dx.doi.org/10.1002/mco2.106

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