Indoxyl Sulfate Contributes to mTORC1-Induced Renal Fibrosis via The OAT/NADPH Oxidase/ROS Pathway

Activation of mTORC1 (mechanistic target of rapamycin complex 1) in renal tissue has been reported in chronic kidney disease (CKD)-induced renal fibrosis. However, the molecular mechanisms responsible for activating mTORC1 in CKD pathology are not well understood. The purpose of this study was to id...

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Detalles Bibliográficos
Autores principales: Nakano, Takehiro, Watanabe, Hiroshi, Imafuku, Tadashi, Tokumaru, Kai, Fujita, Issei, Arimura, Nanaka, Maeda, Hitoshi, Tanaka, Motoko, Matsushita, Kazutaka, Fukagawa, Masafumi, Maruyama, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706756/
https://www.ncbi.nlm.nih.gov/pubmed/34941746
http://dx.doi.org/10.3390/toxins13120909

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