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Early Childhood Pneumonia Is Associated with Reduced Lung Function and Asthma in First Nations Australian Children and Young Adults

Background: Some but not all previous studies report that pneumonia in children aged less than five years is associated with lower lung function and elevated risk of respiratory disease. To date, none have explored these associations in at-risk populations such as First Nations Australians, whose in...

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Autores principales: Collaro, Andrew J., Chang, Anne B., Marchant, Julie M., Chatfield, Mark D., Vicendese, Don, Blake, Tamara L., McElrea, Margaret S., Dharmage, Shyamali C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706766/
https://www.ncbi.nlm.nih.gov/pubmed/34945022
http://dx.doi.org/10.3390/jcm10245727
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author Collaro, Andrew J.
Chang, Anne B.
Marchant, Julie M.
Chatfield, Mark D.
Vicendese, Don
Blake, Tamara L.
McElrea, Margaret S.
Dharmage, Shyamali C.
author_facet Collaro, Andrew J.
Chang, Anne B.
Marchant, Julie M.
Chatfield, Mark D.
Vicendese, Don
Blake, Tamara L.
McElrea, Margaret S.
Dharmage, Shyamali C.
author_sort Collaro, Andrew J.
collection PubMed
description Background: Some but not all previous studies report that pneumonia in children aged less than five years is associated with lower lung function and elevated risk of respiratory disease. To date, none have explored these associations in at-risk populations such as First Nations Australians, whose incidence of early childhood pneumonia is among the highest reported in the world. Methods: This cross-sectional study included 1276 First Nations Australian children/young adults aged 5–25 years recruited from regional/remote Queensland and Northern Territory communities and schools. Associations between pneumonia and both spirometry values and asthma were investigated using linear and logistic regression. Results: Early childhood pneumonia was associated with lower FEV1 and FVC Z-scores, but not FEV1/FVC% Z-scores, when occurring before age three (FEV1 β = −0.42, [95%CI −0.79, −0.04]; FVC β = −0.62, [95%CI −1.14, −0.09]), and between three and five years (β = −0.50, [95%CI −0.88, −0.12]; β = −0.63, [95%CI −1.17, −0.10]), compared to those who never had pneumonia. Similarly, pneumonia occurring when aged before age three years (OR = 3.68, 95%CI 1.96–6.93) and three to five years (OR = 4.81, 95%CI 1.46–15.8) was associated with increased risk of asthma in later childhood. Conclusions: Early childhood pneumonia is associated with lung function deficits and increased asthma risk in later childhood/early adulthood in First Nations Australians. The disproportionate impact of pneumonia on at-risk children must be addressed as a priority.
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spelling pubmed-87067662021-12-25 Early Childhood Pneumonia Is Associated with Reduced Lung Function and Asthma in First Nations Australian Children and Young Adults Collaro, Andrew J. Chang, Anne B. Marchant, Julie M. Chatfield, Mark D. Vicendese, Don Blake, Tamara L. McElrea, Margaret S. Dharmage, Shyamali C. J Clin Med Article Background: Some but not all previous studies report that pneumonia in children aged less than five years is associated with lower lung function and elevated risk of respiratory disease. To date, none have explored these associations in at-risk populations such as First Nations Australians, whose incidence of early childhood pneumonia is among the highest reported in the world. Methods: This cross-sectional study included 1276 First Nations Australian children/young adults aged 5–25 years recruited from regional/remote Queensland and Northern Territory communities and schools. Associations between pneumonia and both spirometry values and asthma were investigated using linear and logistic regression. Results: Early childhood pneumonia was associated with lower FEV1 and FVC Z-scores, but not FEV1/FVC% Z-scores, when occurring before age three (FEV1 β = −0.42, [95%CI −0.79, −0.04]; FVC β = −0.62, [95%CI −1.14, −0.09]), and between three and five years (β = −0.50, [95%CI −0.88, −0.12]; β = −0.63, [95%CI −1.17, −0.10]), compared to those who never had pneumonia. Similarly, pneumonia occurring when aged before age three years (OR = 3.68, 95%CI 1.96–6.93) and three to five years (OR = 4.81, 95%CI 1.46–15.8) was associated with increased risk of asthma in later childhood. Conclusions: Early childhood pneumonia is associated with lung function deficits and increased asthma risk in later childhood/early adulthood in First Nations Australians. The disproportionate impact of pneumonia on at-risk children must be addressed as a priority. MDPI 2021-12-07 /pmc/articles/PMC8706766/ /pubmed/34945022 http://dx.doi.org/10.3390/jcm10245727 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Collaro, Andrew J.
Chang, Anne B.
Marchant, Julie M.
Chatfield, Mark D.
Vicendese, Don
Blake, Tamara L.
McElrea, Margaret S.
Dharmage, Shyamali C.
Early Childhood Pneumonia Is Associated with Reduced Lung Function and Asthma in First Nations Australian Children and Young Adults
title Early Childhood Pneumonia Is Associated with Reduced Lung Function and Asthma in First Nations Australian Children and Young Adults
title_full Early Childhood Pneumonia Is Associated with Reduced Lung Function and Asthma in First Nations Australian Children and Young Adults
title_fullStr Early Childhood Pneumonia Is Associated with Reduced Lung Function and Asthma in First Nations Australian Children and Young Adults
title_full_unstemmed Early Childhood Pneumonia Is Associated with Reduced Lung Function and Asthma in First Nations Australian Children and Young Adults
title_short Early Childhood Pneumonia Is Associated with Reduced Lung Function and Asthma in First Nations Australian Children and Young Adults
title_sort early childhood pneumonia is associated with reduced lung function and asthma in first nations australian children and young adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706766/
https://www.ncbi.nlm.nih.gov/pubmed/34945022
http://dx.doi.org/10.3390/jcm10245727
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