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Investigating the Contribution of Drug-Metabolizing Enzymes in Drug-Drug Interactions of Dapivirine and Miconazole

Dapivirine (DPV) is a potent NNRTI used to prevent the sexual transmission of HIV. In a phase 1 trial (IPM 028), the concomitant use of a DPV vaginal ring and an antifungal miconazole (MIC) vaginal capsule was found to increase the systemic exposure to DPV in women, suggesting a potential for drug-d...

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Detalles Bibliográficos
Autores principales:	Valicherla, Guru Raghavendra, Graebing, Phillip, Zhang, Junmei, Zheng, Ruohui, Nuttall, Jeremy, Silvera, Peter, Rohan, Lisa Cencia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706783/ https://www.ncbi.nlm.nih.gov/pubmed/34959473 http://dx.doi.org/10.3390/pharmaceutics13122193

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