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Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection

(1) Introduction: According to recent studies, the ratio of C-reactive-protein to lymphocyte is more sensitive and specific than other biomarkers associated to systemic inflammatory processes. This study aimed to determine the prognostic value of CLR on COVID-19 severity and mortality at emergency d...

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Autores principales: Tonduangu, Ndenga, Le Borgne, Pierrick, Lefebvre, François, Alame, Karine, Bérard, Lise, Gottwalles, Yannick, Cipolat, Lauriane, Gennai, Stéphane, Bilbault, Pascal, Lavoignet, Charles-Eric, Abensur Vuillaume, Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706788/
https://www.ncbi.nlm.nih.gov/pubmed/34945746
http://dx.doi.org/10.3390/jpm11121274
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author Tonduangu, Ndenga
Le Borgne, Pierrick
Lefebvre, François
Alame, Karine
Bérard, Lise
Gottwalles, Yannick
Cipolat, Lauriane
Gennai, Stéphane
Bilbault, Pascal
Lavoignet, Charles-Eric
Abensur Vuillaume, Laure
author_facet Tonduangu, Ndenga
Le Borgne, Pierrick
Lefebvre, François
Alame, Karine
Bérard, Lise
Gottwalles, Yannick
Cipolat, Lauriane
Gennai, Stéphane
Bilbault, Pascal
Lavoignet, Charles-Eric
Abensur Vuillaume, Laure
author_sort Tonduangu, Ndenga
collection PubMed
description (1) Introduction: According to recent studies, the ratio of C-reactive-protein to lymphocyte is more sensitive and specific than other biomarkers associated to systemic inflammatory processes. This study aimed to determine the prognostic value of CLR on COVID-19 severity and mortality at emergency department (ED) admission. (2) Methods: Between 1 March and 30 April 2020, we carried out a multicenter and retrospective study in six major hospitals of northeast France. The cohort was composed of patients hospitalized for a confirmed diagnosis of moderate to severe COVID-19. (3) Results: A total of 1,035 patients were included in this study. Factors associated with infection severity were the CLR (OR: 1.001, CI 95%: (1.000–1.002), p = 0.012), and the lymphocyte level (OR: 1.951, CI 95%: (1.024–3.717), p = 0.042). In multivariate analysis, the only biochemical factor significantly associated with mortality was lymphocyte rate (OR: 2.308, CI 95%: (1.286–4.141), p = 0.005). The best threshold of CLR to predict the severity of infection was 78.3 (sensitivity 79%; specificity 47%), and to predict mortality, was 159.5 (sensitivity 48%; specificity 70%). (4) Conclusion: The CLR at admission to the ED could be a helpful prognostic biomarker in the early screening and prediction of the severity and mortality associated with SARS-CoV-2 infection.
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spelling pubmed-87067882021-12-25 Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection Tonduangu, Ndenga Le Borgne, Pierrick Lefebvre, François Alame, Karine Bérard, Lise Gottwalles, Yannick Cipolat, Lauriane Gennai, Stéphane Bilbault, Pascal Lavoignet, Charles-Eric Abensur Vuillaume, Laure J Pers Med Article (1) Introduction: According to recent studies, the ratio of C-reactive-protein to lymphocyte is more sensitive and specific than other biomarkers associated to systemic inflammatory processes. This study aimed to determine the prognostic value of CLR on COVID-19 severity and mortality at emergency department (ED) admission. (2) Methods: Between 1 March and 30 April 2020, we carried out a multicenter and retrospective study in six major hospitals of northeast France. The cohort was composed of patients hospitalized for a confirmed diagnosis of moderate to severe COVID-19. (3) Results: A total of 1,035 patients were included in this study. Factors associated with infection severity were the CLR (OR: 1.001, CI 95%: (1.000–1.002), p = 0.012), and the lymphocyte level (OR: 1.951, CI 95%: (1.024–3.717), p = 0.042). In multivariate analysis, the only biochemical factor significantly associated with mortality was lymphocyte rate (OR: 2.308, CI 95%: (1.286–4.141), p = 0.005). The best threshold of CLR to predict the severity of infection was 78.3 (sensitivity 79%; specificity 47%), and to predict mortality, was 159.5 (sensitivity 48%; specificity 70%). (4) Conclusion: The CLR at admission to the ED could be a helpful prognostic biomarker in the early screening and prediction of the severity and mortality associated with SARS-CoV-2 infection. MDPI 2021-12-02 /pmc/articles/PMC8706788/ /pubmed/34945746 http://dx.doi.org/10.3390/jpm11121274 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tonduangu, Ndenga
Le Borgne, Pierrick
Lefebvre, François
Alame, Karine
Bérard, Lise
Gottwalles, Yannick
Cipolat, Lauriane
Gennai, Stéphane
Bilbault, Pascal
Lavoignet, Charles-Eric
Abensur Vuillaume, Laure
Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection
title Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection
title_full Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection
title_fullStr Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection
title_full_unstemmed Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection
title_short Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection
title_sort prognostic value of c-reactive protein to lymphocyte ratio (clr) in emergency department patients with sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706788/
https://www.ncbi.nlm.nih.gov/pubmed/34945746
http://dx.doi.org/10.3390/jpm11121274
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