Cargando…
Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection
(1) Introduction: According to recent studies, the ratio of C-reactive-protein to lymphocyte is more sensitive and specific than other biomarkers associated to systemic inflammatory processes. This study aimed to determine the prognostic value of CLR on COVID-19 severity and mortality at emergency d...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706788/ https://www.ncbi.nlm.nih.gov/pubmed/34945746 http://dx.doi.org/10.3390/jpm11121274 |
_version_ | 1784622277292195840 |
---|---|
author | Tonduangu, Ndenga Le Borgne, Pierrick Lefebvre, François Alame, Karine Bérard, Lise Gottwalles, Yannick Cipolat, Lauriane Gennai, Stéphane Bilbault, Pascal Lavoignet, Charles-Eric Abensur Vuillaume, Laure |
author_facet | Tonduangu, Ndenga Le Borgne, Pierrick Lefebvre, François Alame, Karine Bérard, Lise Gottwalles, Yannick Cipolat, Lauriane Gennai, Stéphane Bilbault, Pascal Lavoignet, Charles-Eric Abensur Vuillaume, Laure |
author_sort | Tonduangu, Ndenga |
collection | PubMed |
description | (1) Introduction: According to recent studies, the ratio of C-reactive-protein to lymphocyte is more sensitive and specific than other biomarkers associated to systemic inflammatory processes. This study aimed to determine the prognostic value of CLR on COVID-19 severity and mortality at emergency department (ED) admission. (2) Methods: Between 1 March and 30 April 2020, we carried out a multicenter and retrospective study in six major hospitals of northeast France. The cohort was composed of patients hospitalized for a confirmed diagnosis of moderate to severe COVID-19. (3) Results: A total of 1,035 patients were included in this study. Factors associated with infection severity were the CLR (OR: 1.001, CI 95%: (1.000–1.002), p = 0.012), and the lymphocyte level (OR: 1.951, CI 95%: (1.024–3.717), p = 0.042). In multivariate analysis, the only biochemical factor significantly associated with mortality was lymphocyte rate (OR: 2.308, CI 95%: (1.286–4.141), p = 0.005). The best threshold of CLR to predict the severity of infection was 78.3 (sensitivity 79%; specificity 47%), and to predict mortality, was 159.5 (sensitivity 48%; specificity 70%). (4) Conclusion: The CLR at admission to the ED could be a helpful prognostic biomarker in the early screening and prediction of the severity and mortality associated with SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-8706788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87067882021-12-25 Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection Tonduangu, Ndenga Le Borgne, Pierrick Lefebvre, François Alame, Karine Bérard, Lise Gottwalles, Yannick Cipolat, Lauriane Gennai, Stéphane Bilbault, Pascal Lavoignet, Charles-Eric Abensur Vuillaume, Laure J Pers Med Article (1) Introduction: According to recent studies, the ratio of C-reactive-protein to lymphocyte is more sensitive and specific than other biomarkers associated to systemic inflammatory processes. This study aimed to determine the prognostic value of CLR on COVID-19 severity and mortality at emergency department (ED) admission. (2) Methods: Between 1 March and 30 April 2020, we carried out a multicenter and retrospective study in six major hospitals of northeast France. The cohort was composed of patients hospitalized for a confirmed diagnosis of moderate to severe COVID-19. (3) Results: A total of 1,035 patients were included in this study. Factors associated with infection severity were the CLR (OR: 1.001, CI 95%: (1.000–1.002), p = 0.012), and the lymphocyte level (OR: 1.951, CI 95%: (1.024–3.717), p = 0.042). In multivariate analysis, the only biochemical factor significantly associated with mortality was lymphocyte rate (OR: 2.308, CI 95%: (1.286–4.141), p = 0.005). The best threshold of CLR to predict the severity of infection was 78.3 (sensitivity 79%; specificity 47%), and to predict mortality, was 159.5 (sensitivity 48%; specificity 70%). (4) Conclusion: The CLR at admission to the ED could be a helpful prognostic biomarker in the early screening and prediction of the severity and mortality associated with SARS-CoV-2 infection. MDPI 2021-12-02 /pmc/articles/PMC8706788/ /pubmed/34945746 http://dx.doi.org/10.3390/jpm11121274 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tonduangu, Ndenga Le Borgne, Pierrick Lefebvre, François Alame, Karine Bérard, Lise Gottwalles, Yannick Cipolat, Lauriane Gennai, Stéphane Bilbault, Pascal Lavoignet, Charles-Eric Abensur Vuillaume, Laure Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection |
title | Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection |
title_full | Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection |
title_fullStr | Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection |
title_full_unstemmed | Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection |
title_short | Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection |
title_sort | prognostic value of c-reactive protein to lymphocyte ratio (clr) in emergency department patients with sars-cov-2 infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706788/ https://www.ncbi.nlm.nih.gov/pubmed/34945746 http://dx.doi.org/10.3390/jpm11121274 |
work_keys_str_mv | AT tonduangundenga prognosticvalueofcreactiveproteintolymphocyteratioclrinemergencydepartmentpatientswithsarscov2infection AT leborgnepierrick prognosticvalueofcreactiveproteintolymphocyteratioclrinemergencydepartmentpatientswithsarscov2infection AT lefebvrefrancois prognosticvalueofcreactiveproteintolymphocyteratioclrinemergencydepartmentpatientswithsarscov2infection AT alamekarine prognosticvalueofcreactiveproteintolymphocyteratioclrinemergencydepartmentpatientswithsarscov2infection AT berardlise prognosticvalueofcreactiveproteintolymphocyteratioclrinemergencydepartmentpatientswithsarscov2infection AT gottwallesyannick prognosticvalueofcreactiveproteintolymphocyteratioclrinemergencydepartmentpatientswithsarscov2infection AT cipolatlauriane prognosticvalueofcreactiveproteintolymphocyteratioclrinemergencydepartmentpatientswithsarscov2infection AT gennaistephane prognosticvalueofcreactiveproteintolymphocyteratioclrinemergencydepartmentpatientswithsarscov2infection AT bilbaultpascal prognosticvalueofcreactiveproteintolymphocyteratioclrinemergencydepartmentpatientswithsarscov2infection AT lavoignetcharleseric prognosticvalueofcreactiveproteintolymphocyteratioclrinemergencydepartmentpatientswithsarscov2infection AT abensurvuillaumelaure prognosticvalueofcreactiveproteintolymphocyteratioclrinemergencydepartmentpatientswithsarscov2infection AT prognosticvalueofcreactiveproteintolymphocyteratioclrinemergencydepartmentpatientswithsarscov2infection |