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The QOSMOS Study: Pharmacist-Led Multicentered Observational Study on Quality of Life in Multiple Sclerosis
Health-related quality of life is frequently included in patient-reported outcomes aimed at evaluating the effectiveness of disease-modifying drugs for multiple sclerosis, but recent data about Italian patients are missing. A multicenter observational and cross-sectional study was performed by stude...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706851/ https://www.ncbi.nlm.nih.gov/pubmed/34940751 http://dx.doi.org/10.3390/neurolint13040065 |
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author | Damuzzo, Vera Agnoletto, Laura Rampazzo, Roberta Cammalleri, Francesca Cancanelli, Luca Chiumente, Marco Costantino, Stefano Michielan, Silvia Milani, Federica Sartori, Alessia Rivano, Melania Mengato, Daniele |
author_facet | Damuzzo, Vera Agnoletto, Laura Rampazzo, Roberta Cammalleri, Francesca Cancanelli, Luca Chiumente, Marco Costantino, Stefano Michielan, Silvia Milani, Federica Sartori, Alessia Rivano, Melania Mengato, Daniele |
author_sort | Damuzzo, Vera |
collection | PubMed |
description | Health-related quality of life is frequently included in patient-reported outcomes aimed at evaluating the effectiveness of disease-modifying drugs for multiple sclerosis, but recent data about Italian patients are missing. A multicenter observational and cross-sectional study was performed by students of hospital pharmacy to update existing data on quality of life and to correlate it with the pharmacological and medical history of patients. Quality of life (QoL) was assessed using the MS-QoL54 questionnaire, and the pharmacist collected patients’ characteristics, medical and pharmacological history, and Expanded Disability Status Scale (EDSS). Three hundred and forty-nine patients with multiple sclerosis were recruited from 16 centers between May 2018 and June 2019 (median age = 44.1 years; 68.9% women). The composite indexes of physical and mental well-being showed direct correlation with each other (R = 0.826; p < 0.001), and EDSS disability was an independent negative predictor of both indexes (R(2) = 35.08% p < 0.001 and R(2) = 15.74% p < 0.001, respectively). A trend of association between Physical Health Composite Score and different classes of oral disease-modifying drugs (DMDs) was observed. Our study found a decrease in QoL correlated with teriflunomide, which deserves further investigation. This experience demonstrates that joint action between scientific society and students association can be successful in conducting a no-profit multicenter observational study in a real-world setting. |
format | Online Article Text |
id | pubmed-8706851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87068512021-12-25 The QOSMOS Study: Pharmacist-Led Multicentered Observational Study on Quality of Life in Multiple Sclerosis Damuzzo, Vera Agnoletto, Laura Rampazzo, Roberta Cammalleri, Francesca Cancanelli, Luca Chiumente, Marco Costantino, Stefano Michielan, Silvia Milani, Federica Sartori, Alessia Rivano, Melania Mengato, Daniele Neurol Int Article Health-related quality of life is frequently included in patient-reported outcomes aimed at evaluating the effectiveness of disease-modifying drugs for multiple sclerosis, but recent data about Italian patients are missing. A multicenter observational and cross-sectional study was performed by students of hospital pharmacy to update existing data on quality of life and to correlate it with the pharmacological and medical history of patients. Quality of life (QoL) was assessed using the MS-QoL54 questionnaire, and the pharmacist collected patients’ characteristics, medical and pharmacological history, and Expanded Disability Status Scale (EDSS). Three hundred and forty-nine patients with multiple sclerosis were recruited from 16 centers between May 2018 and June 2019 (median age = 44.1 years; 68.9% women). The composite indexes of physical and mental well-being showed direct correlation with each other (R = 0.826; p < 0.001), and EDSS disability was an independent negative predictor of both indexes (R(2) = 35.08% p < 0.001 and R(2) = 15.74% p < 0.001, respectively). A trend of association between Physical Health Composite Score and different classes of oral disease-modifying drugs (DMDs) was observed. Our study found a decrease in QoL correlated with teriflunomide, which deserves further investigation. This experience demonstrates that joint action between scientific society and students association can be successful in conducting a no-profit multicenter observational study in a real-world setting. MDPI 2021-12-03 /pmc/articles/PMC8706851/ /pubmed/34940751 http://dx.doi.org/10.3390/neurolint13040065 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Damuzzo, Vera Agnoletto, Laura Rampazzo, Roberta Cammalleri, Francesca Cancanelli, Luca Chiumente, Marco Costantino, Stefano Michielan, Silvia Milani, Federica Sartori, Alessia Rivano, Melania Mengato, Daniele The QOSMOS Study: Pharmacist-Led Multicentered Observational Study on Quality of Life in Multiple Sclerosis |
title | The QOSMOS Study: Pharmacist-Led Multicentered Observational Study on Quality of Life in Multiple Sclerosis |
title_full | The QOSMOS Study: Pharmacist-Led Multicentered Observational Study on Quality of Life in Multiple Sclerosis |
title_fullStr | The QOSMOS Study: Pharmacist-Led Multicentered Observational Study on Quality of Life in Multiple Sclerosis |
title_full_unstemmed | The QOSMOS Study: Pharmacist-Led Multicentered Observational Study on Quality of Life in Multiple Sclerosis |
title_short | The QOSMOS Study: Pharmacist-Led Multicentered Observational Study on Quality of Life in Multiple Sclerosis |
title_sort | qosmos study: pharmacist-led multicentered observational study on quality of life in multiple sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706851/ https://www.ncbi.nlm.nih.gov/pubmed/34940751 http://dx.doi.org/10.3390/neurolint13040065 |
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