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Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children

Background: Inadequate vitamin D levels may increase the risk of caries during childhood. The purpose of this study was to investigate the association between 25-hydroxyvitamin D (25(OH)D) status and severe early childhood caries (S-ECC) in preschool children. Methods: Data were obtained from childr...

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Autores principales: Williams, Tiffany L., Boyle, Joseph, Mittermuller, Betty-Anne, Carrico, Caroline, Schroth, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706858/
https://www.ncbi.nlm.nih.gov/pubmed/34960016
http://dx.doi.org/10.3390/nu13124465
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author Williams, Tiffany L.
Boyle, Joseph
Mittermuller, Betty-Anne
Carrico, Caroline
Schroth, Robert J.
author_facet Williams, Tiffany L.
Boyle, Joseph
Mittermuller, Betty-Anne
Carrico, Caroline
Schroth, Robert J.
author_sort Williams, Tiffany L.
collection PubMed
description Background: Inadequate vitamin D levels may increase the risk of caries during childhood. The purpose of this study was to investigate the association between 25-hydroxyvitamin D (25(OH)D) status and severe early childhood caries (S-ECC) in preschool children. Methods: Data were obtained from children <72 months of age in two case–control studies in Winnipeg, Manitoba and Richmond, Virginia. Serum analysis assessed 25(OH)D, calcium and parathyroid concentrations. Data on demographics, dental history and oral hygiene were obtained via questionnaires. Bivariate and multiple logistic regression analyses were performed to assess the relationships between demographic and biological variables and S-ECC. A p-value of ≤0.05 was significant. Results: Data were available for 200 children with S-ECC and 144 caries-free controls. Children with S-ECC had significantly lower 25(OH)D levels than those who were caries-free (p < 0.001), and children with deficient 25(OH)D levels were 10 times more likely to have S-ECC (p < 0.001). Multiple logistic regression revealed that having higher 25(OH)D and calcium concentrations (p = 0.019 and p < 0.0001, respectively), as well as being breastfed in infancy (p < 0.001), were significantly and independently associated with lower odds of S-ECC, while dental insurance (p = 0.006) was associated with higher odds of S-ECC. Conclusions: This study provides additional evidence of an association between nutritional status, specifically vitamin D and calcium levels, and S-ECC.
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spelling pubmed-87068582021-12-25 Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children Williams, Tiffany L. Boyle, Joseph Mittermuller, Betty-Anne Carrico, Caroline Schroth, Robert J. Nutrients Article Background: Inadequate vitamin D levels may increase the risk of caries during childhood. The purpose of this study was to investigate the association between 25-hydroxyvitamin D (25(OH)D) status and severe early childhood caries (S-ECC) in preschool children. Methods: Data were obtained from children <72 months of age in two case–control studies in Winnipeg, Manitoba and Richmond, Virginia. Serum analysis assessed 25(OH)D, calcium and parathyroid concentrations. Data on demographics, dental history and oral hygiene were obtained via questionnaires. Bivariate and multiple logistic regression analyses were performed to assess the relationships between demographic and biological variables and S-ECC. A p-value of ≤0.05 was significant. Results: Data were available for 200 children with S-ECC and 144 caries-free controls. Children with S-ECC had significantly lower 25(OH)D levels than those who were caries-free (p < 0.001), and children with deficient 25(OH)D levels were 10 times more likely to have S-ECC (p < 0.001). Multiple logistic regression revealed that having higher 25(OH)D and calcium concentrations (p = 0.019 and p < 0.0001, respectively), as well as being breastfed in infancy (p < 0.001), were significantly and independently associated with lower odds of S-ECC, while dental insurance (p = 0.006) was associated with higher odds of S-ECC. Conclusions: This study provides additional evidence of an association between nutritional status, specifically vitamin D and calcium levels, and S-ECC. MDPI 2021-12-14 /pmc/articles/PMC8706858/ /pubmed/34960016 http://dx.doi.org/10.3390/nu13124465 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Williams, Tiffany L.
Boyle, Joseph
Mittermuller, Betty-Anne
Carrico, Caroline
Schroth, Robert J.
Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children
title Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children
title_full Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children
title_fullStr Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children
title_full_unstemmed Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children
title_short Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children
title_sort association between vitamin d and dental caries in a sample of canadian and american preschool-aged children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706858/
https://www.ncbi.nlm.nih.gov/pubmed/34960016
http://dx.doi.org/10.3390/nu13124465
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