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The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases
The human G-leukocyte antigen (HLA-G) molecule is a non-classical major histocompatibility complex (MHC) class I molecule. The pertinence of HLA-G has been investigated in numerous studies which have sought to elucidate the relevance of HLA-G in pathologic conditions, such as autoimmune diseases, ca...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706866/ https://www.ncbi.nlm.nih.gov/pubmed/34948145 http://dx.doi.org/10.3390/ijms222413348 |
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author | Zaborek-Łyczba, Monika Łyczba, Jakub Mertowska, Paulina Mertowski, Sebastian Hymos, Anna Podgajna, Martyna Niedźwiedzka-Rystwej, Paulina Grywalska, Ewelina |
author_facet | Zaborek-Łyczba, Monika Łyczba, Jakub Mertowska, Paulina Mertowski, Sebastian Hymos, Anna Podgajna, Martyna Niedźwiedzka-Rystwej, Paulina Grywalska, Ewelina |
author_sort | Zaborek-Łyczba, Monika |
collection | PubMed |
description | The human G-leukocyte antigen (HLA-G) molecule is a non-classical major histocompatibility complex (MHC) class I molecule. The pertinence of HLA-G has been investigated in numerous studies which have sought to elucidate the relevance of HLA-G in pathologic conditions, such as autoimmune diseases, cancers, and hematologic malignancies. One of the main goals of the current research on HLA-G is to use this molecule in clinical practice, either in diagnostics or as a therapeutic target. Since HLA-G antigens are currently considered as immunomodulatory molecules that are involved in reducing inflammatory and immune responses, in this review, we decided to focus on this group of antigens as potential determinants of progression in autoimmune diseases. This article highlights what we consider as recent pivotal findings on the immunomodulatory function of HLA-G, not only to establish the role of HLA-G in the human body, but also to explain how these proteins mediate the immune response. |
format | Online Article Text |
id | pubmed-8706866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87068662021-12-25 The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases Zaborek-Łyczba, Monika Łyczba, Jakub Mertowska, Paulina Mertowski, Sebastian Hymos, Anna Podgajna, Martyna Niedźwiedzka-Rystwej, Paulina Grywalska, Ewelina Int J Mol Sci Review The human G-leukocyte antigen (HLA-G) molecule is a non-classical major histocompatibility complex (MHC) class I molecule. The pertinence of HLA-G has been investigated in numerous studies which have sought to elucidate the relevance of HLA-G in pathologic conditions, such as autoimmune diseases, cancers, and hematologic malignancies. One of the main goals of the current research on HLA-G is to use this molecule in clinical practice, either in diagnostics or as a therapeutic target. Since HLA-G antigens are currently considered as immunomodulatory molecules that are involved in reducing inflammatory and immune responses, in this review, we decided to focus on this group of antigens as potential determinants of progression in autoimmune diseases. This article highlights what we consider as recent pivotal findings on the immunomodulatory function of HLA-G, not only to establish the role of HLA-G in the human body, but also to explain how these proteins mediate the immune response. MDPI 2021-12-12 /pmc/articles/PMC8706866/ /pubmed/34948145 http://dx.doi.org/10.3390/ijms222413348 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zaborek-Łyczba, Monika Łyczba, Jakub Mertowska, Paulina Mertowski, Sebastian Hymos, Anna Podgajna, Martyna Niedźwiedzka-Rystwej, Paulina Grywalska, Ewelina The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases |
title | The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases |
title_full | The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases |
title_fullStr | The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases |
title_full_unstemmed | The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases |
title_short | The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases |
title_sort | hla-g immune checkpoint plays a pivotal role in the regulation of immune response in autoimmune diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706866/ https://www.ncbi.nlm.nih.gov/pubmed/34948145 http://dx.doi.org/10.3390/ijms222413348 |
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