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The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases

The human G-leukocyte antigen (HLA-G) molecule is a non-classical major histocompatibility complex (MHC) class I molecule. The pertinence of HLA-G has been investigated in numerous studies which have sought to elucidate the relevance of HLA-G in pathologic conditions, such as autoimmune diseases, ca...

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Autores principales: Zaborek-Łyczba, Monika, Łyczba, Jakub, Mertowska, Paulina, Mertowski, Sebastian, Hymos, Anna, Podgajna, Martyna, Niedźwiedzka-Rystwej, Paulina, Grywalska, Ewelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706866/
https://www.ncbi.nlm.nih.gov/pubmed/34948145
http://dx.doi.org/10.3390/ijms222413348
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author Zaborek-Łyczba, Monika
Łyczba, Jakub
Mertowska, Paulina
Mertowski, Sebastian
Hymos, Anna
Podgajna, Martyna
Niedźwiedzka-Rystwej, Paulina
Grywalska, Ewelina
author_facet Zaborek-Łyczba, Monika
Łyczba, Jakub
Mertowska, Paulina
Mertowski, Sebastian
Hymos, Anna
Podgajna, Martyna
Niedźwiedzka-Rystwej, Paulina
Grywalska, Ewelina
author_sort Zaborek-Łyczba, Monika
collection PubMed
description The human G-leukocyte antigen (HLA-G) molecule is a non-classical major histocompatibility complex (MHC) class I molecule. The pertinence of HLA-G has been investigated in numerous studies which have sought to elucidate the relevance of HLA-G in pathologic conditions, such as autoimmune diseases, cancers, and hematologic malignancies. One of the main goals of the current research on HLA-G is to use this molecule in clinical practice, either in diagnostics or as a therapeutic target. Since HLA-G antigens are currently considered as immunomodulatory molecules that are involved in reducing inflammatory and immune responses, in this review, we decided to focus on this group of antigens as potential determinants of progression in autoimmune diseases. This article highlights what we consider as recent pivotal findings on the immunomodulatory function of HLA-G, not only to establish the role of HLA-G in the human body, but also to explain how these proteins mediate the immune response.
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spelling pubmed-87068662021-12-25 The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases Zaborek-Łyczba, Monika Łyczba, Jakub Mertowska, Paulina Mertowski, Sebastian Hymos, Anna Podgajna, Martyna Niedźwiedzka-Rystwej, Paulina Grywalska, Ewelina Int J Mol Sci Review The human G-leukocyte antigen (HLA-G) molecule is a non-classical major histocompatibility complex (MHC) class I molecule. The pertinence of HLA-G has been investigated in numerous studies which have sought to elucidate the relevance of HLA-G in pathologic conditions, such as autoimmune diseases, cancers, and hematologic malignancies. One of the main goals of the current research on HLA-G is to use this molecule in clinical practice, either in diagnostics or as a therapeutic target. Since HLA-G antigens are currently considered as immunomodulatory molecules that are involved in reducing inflammatory and immune responses, in this review, we decided to focus on this group of antigens as potential determinants of progression in autoimmune diseases. This article highlights what we consider as recent pivotal findings on the immunomodulatory function of HLA-G, not only to establish the role of HLA-G in the human body, but also to explain how these proteins mediate the immune response. MDPI 2021-12-12 /pmc/articles/PMC8706866/ /pubmed/34948145 http://dx.doi.org/10.3390/ijms222413348 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zaborek-Łyczba, Monika
Łyczba, Jakub
Mertowska, Paulina
Mertowski, Sebastian
Hymos, Anna
Podgajna, Martyna
Niedźwiedzka-Rystwej, Paulina
Grywalska, Ewelina
The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases
title The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases
title_full The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases
title_fullStr The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases
title_full_unstemmed The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases
title_short The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases
title_sort hla-g immune checkpoint plays a pivotal role in the regulation of immune response in autoimmune diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706866/
https://www.ncbi.nlm.nih.gov/pubmed/34948145
http://dx.doi.org/10.3390/ijms222413348
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