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Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells

The molecular pathophysiology of cardiometabolic diseases is known to be influenced by dysfunctional ectopic adipose tissue. In addition to lifestyle improvements, these conditions may be managed by novel nutraceutical products. This study evaluatedthe effects of 11 Cameroonian medicinal spice extra...

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Autores principales: Atchan Nwakiban, Achille Parfait, Passarelli, Anna, Da Dalt, Lorenzo, Olivieri, Chiara, Demirci, Tugba Nur, Piazza, Stefano, Sangiovanni, Enrico, Carpentier-Maguire, Eugénie, Martinelli, Giulia, Shivashankara, Shilpa Talkad, Manjappara, Uma Venkateswaran, Tchamgoue, Armelle Deutou, Agbor, Gabriel Agbor, Kuiate, Jules-Roger, Daglia, Maria, Dell’Agli, Mario, Magni, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706885/
https://www.ncbi.nlm.nih.gov/pubmed/34959824
http://dx.doi.org/10.3390/nu13124271
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author Atchan Nwakiban, Achille Parfait
Passarelli, Anna
Da Dalt, Lorenzo
Olivieri, Chiara
Demirci, Tugba Nur
Piazza, Stefano
Sangiovanni, Enrico
Carpentier-Maguire, Eugénie
Martinelli, Giulia
Shivashankara, Shilpa Talkad
Manjappara, Uma Venkateswaran
Tchamgoue, Armelle Deutou
Agbor, Gabriel Agbor
Kuiate, Jules-Roger
Daglia, Maria
Dell’Agli, Mario
Magni, Paolo
author_facet Atchan Nwakiban, Achille Parfait
Passarelli, Anna
Da Dalt, Lorenzo
Olivieri, Chiara
Demirci, Tugba Nur
Piazza, Stefano
Sangiovanni, Enrico
Carpentier-Maguire, Eugénie
Martinelli, Giulia
Shivashankara, Shilpa Talkad
Manjappara, Uma Venkateswaran
Tchamgoue, Armelle Deutou
Agbor, Gabriel Agbor
Kuiate, Jules-Roger
Daglia, Maria
Dell’Agli, Mario
Magni, Paolo
author_sort Atchan Nwakiban, Achille Parfait
collection PubMed
description The molecular pathophysiology of cardiometabolic diseases is known to be influenced by dysfunctional ectopic adipose tissue. In addition to lifestyle improvements, these conditions may be managed by novel nutraceutical products. This study evaluatedthe effects of 11 Cameroonian medicinal spice extracts on triglyceride accumulation, glucose uptake, reactive oxygen species (ROS) production and interleukin secretion in SW 872 human adipocytes after differentiation with 100 µM oleic acid. Triglyceride content was significantly reduced by all spice extracts. Glucose uptake was significantly increased by Tetrapleura tetraptera, Aframomum melegueta and Zanthoxylum leprieurii. Moreover, Xylopia parviflora, Echinops giganteus and Dichrostachys glomerata significantly reduced the production of ROS. Concerning pro-inflammatory cytokine secretion, we observed that Tetrapleura tetraptera, Echinops giganteus, Dichrostachys glomerata and Aframomum melegueta reduced IL-6 secretion. In addition, Xylopia parviflora, Monodora myristica, Zanthoxylum leprieurii, and Xylopia aethiopica reduced IL-8 secretion, while Dichrostachys glomerata and Aframomum citratum increased it. These findings highlight some interesting properties of these Cameroonian spice extracts in the modulation of cellular parameters relevant to cardiometabolic diseases, which may be further exploited, aiming to develop novel treatment options for these conditions based on nutraceutical products.
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spelling pubmed-87068852021-12-25 Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells Atchan Nwakiban, Achille Parfait Passarelli, Anna Da Dalt, Lorenzo Olivieri, Chiara Demirci, Tugba Nur Piazza, Stefano Sangiovanni, Enrico Carpentier-Maguire, Eugénie Martinelli, Giulia Shivashankara, Shilpa Talkad Manjappara, Uma Venkateswaran Tchamgoue, Armelle Deutou Agbor, Gabriel Agbor Kuiate, Jules-Roger Daglia, Maria Dell’Agli, Mario Magni, Paolo Nutrients Article The molecular pathophysiology of cardiometabolic diseases is known to be influenced by dysfunctional ectopic adipose tissue. In addition to lifestyle improvements, these conditions may be managed by novel nutraceutical products. This study evaluatedthe effects of 11 Cameroonian medicinal spice extracts on triglyceride accumulation, glucose uptake, reactive oxygen species (ROS) production and interleukin secretion in SW 872 human adipocytes after differentiation with 100 µM oleic acid. Triglyceride content was significantly reduced by all spice extracts. Glucose uptake was significantly increased by Tetrapleura tetraptera, Aframomum melegueta and Zanthoxylum leprieurii. Moreover, Xylopia parviflora, Echinops giganteus and Dichrostachys glomerata significantly reduced the production of ROS. Concerning pro-inflammatory cytokine secretion, we observed that Tetrapleura tetraptera, Echinops giganteus, Dichrostachys glomerata and Aframomum melegueta reduced IL-6 secretion. In addition, Xylopia parviflora, Monodora myristica, Zanthoxylum leprieurii, and Xylopia aethiopica reduced IL-8 secretion, while Dichrostachys glomerata and Aframomum citratum increased it. These findings highlight some interesting properties of these Cameroonian spice extracts in the modulation of cellular parameters relevant to cardiometabolic diseases, which may be further exploited, aiming to develop novel treatment options for these conditions based on nutraceutical products. MDPI 2021-11-26 /pmc/articles/PMC8706885/ /pubmed/34959824 http://dx.doi.org/10.3390/nu13124271 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Atchan Nwakiban, Achille Parfait
Passarelli, Anna
Da Dalt, Lorenzo
Olivieri, Chiara
Demirci, Tugba Nur
Piazza, Stefano
Sangiovanni, Enrico
Carpentier-Maguire, Eugénie
Martinelli, Giulia
Shivashankara, Shilpa Talkad
Manjappara, Uma Venkateswaran
Tchamgoue, Armelle Deutou
Agbor, Gabriel Agbor
Kuiate, Jules-Roger
Daglia, Maria
Dell’Agli, Mario
Magni, Paolo
Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells
title Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells
title_full Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells
title_fullStr Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells
title_full_unstemmed Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells
title_short Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells
title_sort cameroonian spice extracts modulate molecular mechanisms relevant to cardiometabolic diseases in sw 872 human liposarcoma cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706885/
https://www.ncbi.nlm.nih.gov/pubmed/34959824
http://dx.doi.org/10.3390/nu13124271
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