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Economic Burden of Pneumococcal Disease in Individuals Aged 15 Years and Older in the Liguria Region of Italy

Despite the availability of vaccines against Streptococcus pneumoniae, the global incidence and economic cost of pneumococcal disease (PD) among adults is still high. This retrospective cohort analysis estimated the cost of emergency department (ED) visits/hospitalizations associated with non-invasi...

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Autores principales: Astengo, Matteo, Paganino, Chiara, Amicizia, Daniela, Trucchi, Cecilia, Tassinari, Federico, Sticchi, Camilla, Sticchi, Laura, Orsi, Andrea, Icardi, Giancarlo, Piazza, Maria Francesca, Di Silverio, Bruno, Deb, Arijita, Senese, Francesca, Prandi, Gian Marco, Ansaldi, Filippo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706914/
https://www.ncbi.nlm.nih.gov/pubmed/34960127
http://dx.doi.org/10.3390/vaccines9121380
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author Astengo, Matteo
Paganino, Chiara
Amicizia, Daniela
Trucchi, Cecilia
Tassinari, Federico
Sticchi, Camilla
Sticchi, Laura
Orsi, Andrea
Icardi, Giancarlo
Piazza, Maria Francesca
Di Silverio, Bruno
Deb, Arijita
Senese, Francesca
Prandi, Gian Marco
Ansaldi, Filippo
author_facet Astengo, Matteo
Paganino, Chiara
Amicizia, Daniela
Trucchi, Cecilia
Tassinari, Federico
Sticchi, Camilla
Sticchi, Laura
Orsi, Andrea
Icardi, Giancarlo
Piazza, Maria Francesca
Di Silverio, Bruno
Deb, Arijita
Senese, Francesca
Prandi, Gian Marco
Ansaldi, Filippo
author_sort Astengo, Matteo
collection PubMed
description Despite the availability of vaccines against Streptococcus pneumoniae, the global incidence and economic cost of pneumococcal disease (PD) among adults is still high. This retrospective cohort analysis estimated the cost of emergency department (ED) visits/hospitalizations associated with non-invasive pneumonia and invasive pneumococcal disease among individuals ≥15 years of age in the Liguria region of Italy during 2012–2018. Data from the Liguria Region Administrative Health Databases and the Ligurian Chronic Condition Data Warehouse were used, including hospital admission date, length of stay, discharge date, outpatient visits, and laboratory/imaging procedures. A ≥30-day gap between two events defined a new episode, and patients with ≥1 ED or inpatient claim for PD were identified. The total mean annual number of hospitalizations for PD was 13,450, costing ~€49 million per year. Pneumonia accounted for the majority of hospitalization costs. The median annual cost of hospitalization for all-cause pneumonia was €38,416,440 (per-capita cost: €26.78) and was €30,353,928 (per-capita cost: €20.88) for pneumococcal and unspecified pneumonia. The total number and associated costs of ED visits/hospitalizations generally increased over the study period. PD still incurs high economic costs in adults in the Liguria region of Italy.
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spelling pubmed-87069142021-12-25 Economic Burden of Pneumococcal Disease in Individuals Aged 15 Years and Older in the Liguria Region of Italy Astengo, Matteo Paganino, Chiara Amicizia, Daniela Trucchi, Cecilia Tassinari, Federico Sticchi, Camilla Sticchi, Laura Orsi, Andrea Icardi, Giancarlo Piazza, Maria Francesca Di Silverio, Bruno Deb, Arijita Senese, Francesca Prandi, Gian Marco Ansaldi, Filippo Vaccines (Basel) Article Despite the availability of vaccines against Streptococcus pneumoniae, the global incidence and economic cost of pneumococcal disease (PD) among adults is still high. This retrospective cohort analysis estimated the cost of emergency department (ED) visits/hospitalizations associated with non-invasive pneumonia and invasive pneumococcal disease among individuals ≥15 years of age in the Liguria region of Italy during 2012–2018. Data from the Liguria Region Administrative Health Databases and the Ligurian Chronic Condition Data Warehouse were used, including hospital admission date, length of stay, discharge date, outpatient visits, and laboratory/imaging procedures. A ≥30-day gap between two events defined a new episode, and patients with ≥1 ED or inpatient claim for PD were identified. The total mean annual number of hospitalizations for PD was 13,450, costing ~€49 million per year. Pneumonia accounted for the majority of hospitalization costs. The median annual cost of hospitalization for all-cause pneumonia was €38,416,440 (per-capita cost: €26.78) and was €30,353,928 (per-capita cost: €20.88) for pneumococcal and unspecified pneumonia. The total number and associated costs of ED visits/hospitalizations generally increased over the study period. PD still incurs high economic costs in adults in the Liguria region of Italy. MDPI 2021-11-24 /pmc/articles/PMC8706914/ /pubmed/34960127 http://dx.doi.org/10.3390/vaccines9121380 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Astengo, Matteo
Paganino, Chiara
Amicizia, Daniela
Trucchi, Cecilia
Tassinari, Federico
Sticchi, Camilla
Sticchi, Laura
Orsi, Andrea
Icardi, Giancarlo
Piazza, Maria Francesca
Di Silverio, Bruno
Deb, Arijita
Senese, Francesca
Prandi, Gian Marco
Ansaldi, Filippo
Economic Burden of Pneumococcal Disease in Individuals Aged 15 Years and Older in the Liguria Region of Italy
title Economic Burden of Pneumococcal Disease in Individuals Aged 15 Years and Older in the Liguria Region of Italy
title_full Economic Burden of Pneumococcal Disease in Individuals Aged 15 Years and Older in the Liguria Region of Italy
title_fullStr Economic Burden of Pneumococcal Disease in Individuals Aged 15 Years and Older in the Liguria Region of Italy
title_full_unstemmed Economic Burden of Pneumococcal Disease in Individuals Aged 15 Years and Older in the Liguria Region of Italy
title_short Economic Burden of Pneumococcal Disease in Individuals Aged 15 Years and Older in the Liguria Region of Italy
title_sort economic burden of pneumococcal disease in individuals aged 15 years and older in the liguria region of italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706914/
https://www.ncbi.nlm.nih.gov/pubmed/34960127
http://dx.doi.org/10.3390/vaccines9121380
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