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Stability of Liver Radiomics across Different 3D ROI Sizes—An MRI In Vivo Study
We aimed to evaluate the stability of radiomic features in the liver of healthy individuals across different three-dimensional regions of interest (3D ROI) sizes in T1-weighted (T1w) and T2-weighted (T2w) images from different MR scanners. We retrospectively included 66 examinations of patients with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706942/ https://www.ncbi.nlm.nih.gov/pubmed/34941645 http://dx.doi.org/10.3390/tomography7040073 |
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author | Jensen, Laura J. Kim, Damon Elgeti, Thomas Steffen, Ingo G. Hamm, Bernd Nagel, Sebastian N. |
author_facet | Jensen, Laura J. Kim, Damon Elgeti, Thomas Steffen, Ingo G. Hamm, Bernd Nagel, Sebastian N. |
author_sort | Jensen, Laura J. |
collection | PubMed |
description | We aimed to evaluate the stability of radiomic features in the liver of healthy individuals across different three-dimensional regions of interest (3D ROI) sizes in T1-weighted (T1w) and T2-weighted (T2w) images from different MR scanners. We retrospectively included 66 examinations of patients without known diseases or pathological imaging findings acquired on three MRI scanners (3 Tesla I: 25 patients, 3 Tesla II: 19 patients, 1.5 Tesla: 22 patients). 3D ROIs of different diameters (10, 20, 30 mm) were drawn on T1w GRE and T2w TSE images into the liver parenchyma (segment V–VIII). We extracted 93 radiomic features from the different ROIs and tested features for significant differences with the Mann–Whitney-U (MWU)-test. The MWU-test revealed significant differences for most second- and higher-order features, indicating a systematic difference dependent on the ROI size. The features mean, median, root mean squared (RMS), 10th percentile, and 90th percentile were not significantly different. We also assessed feature robustness to ROI size variation with overall concordance correlation coefficients (OCCCs). OCCCs across the different ROI-sizes for mean, median, and RMS were excellent (>0.90) in both sequences on all three scanners. These features, therefore, seem robust to ROI-size variation and suitable for radiomic studies of liver MRI. |
format | Online Article Text |
id | pubmed-8706942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87069422021-12-25 Stability of Liver Radiomics across Different 3D ROI Sizes—An MRI In Vivo Study Jensen, Laura J. Kim, Damon Elgeti, Thomas Steffen, Ingo G. Hamm, Bernd Nagel, Sebastian N. Tomography Article We aimed to evaluate the stability of radiomic features in the liver of healthy individuals across different three-dimensional regions of interest (3D ROI) sizes in T1-weighted (T1w) and T2-weighted (T2w) images from different MR scanners. We retrospectively included 66 examinations of patients without known diseases or pathological imaging findings acquired on three MRI scanners (3 Tesla I: 25 patients, 3 Tesla II: 19 patients, 1.5 Tesla: 22 patients). 3D ROIs of different diameters (10, 20, 30 mm) were drawn on T1w GRE and T2w TSE images into the liver parenchyma (segment V–VIII). We extracted 93 radiomic features from the different ROIs and tested features for significant differences with the Mann–Whitney-U (MWU)-test. The MWU-test revealed significant differences for most second- and higher-order features, indicating a systematic difference dependent on the ROI size. The features mean, median, root mean squared (RMS), 10th percentile, and 90th percentile were not significantly different. We also assessed feature robustness to ROI size variation with overall concordance correlation coefficients (OCCCs). OCCCs across the different ROI-sizes for mean, median, and RMS were excellent (>0.90) in both sequences on all three scanners. These features, therefore, seem robust to ROI-size variation and suitable for radiomic studies of liver MRI. MDPI 2021-12-03 /pmc/articles/PMC8706942/ /pubmed/34941645 http://dx.doi.org/10.3390/tomography7040073 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jensen, Laura J. Kim, Damon Elgeti, Thomas Steffen, Ingo G. Hamm, Bernd Nagel, Sebastian N. Stability of Liver Radiomics across Different 3D ROI Sizes—An MRI In Vivo Study |
title | Stability of Liver Radiomics across Different 3D ROI Sizes—An MRI In Vivo Study |
title_full | Stability of Liver Radiomics across Different 3D ROI Sizes—An MRI In Vivo Study |
title_fullStr | Stability of Liver Radiomics across Different 3D ROI Sizes—An MRI In Vivo Study |
title_full_unstemmed | Stability of Liver Radiomics across Different 3D ROI Sizes—An MRI In Vivo Study |
title_short | Stability of Liver Radiomics across Different 3D ROI Sizes—An MRI In Vivo Study |
title_sort | stability of liver radiomics across different 3d roi sizes—an mri in vivo study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706942/ https://www.ncbi.nlm.nih.gov/pubmed/34941645 http://dx.doi.org/10.3390/tomography7040073 |
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