High-Throughput Profiling of Cas12a Orthologues and Engineered Variants for Enhanced Genome Editing Activity

CRISPR/Cas12a (formerly Cpf1), an RNA-guided endonuclease of the Class II Type V-A CRISPR system, provides a promising tool for genome engineering. Over 10 Cas12a orthologues have been identified and employed for gene editing in human cells. However, the functional diversity among emerging Cas12a or...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Dan, Wang, Junyi, Yang, Di, Xi, Jianzhong, Li, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706968/
https://www.ncbi.nlm.nih.gov/pubmed/34948095
http://dx.doi.org/10.3390/ijms222413301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706968/
https://www.ncbi.nlm.nih.gov/pubmed/34948095
http://dx.doi.org/10.3390/ijms222413301

Ejemplares similares