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High-Throughput Profiling of Cas12a Orthologues and Engineered Variants for Enhanced Genome Editing Activity

CRISPR/Cas12a (formerly Cpf1), an RNA-guided endonuclease of the Class II Type V-A CRISPR system, provides a promising tool for genome engineering. Over 10 Cas12a orthologues have been identified and employed for gene editing in human cells. However, the functional diversity among emerging Cas12a or...

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Detalles Bibliográficos
Autores principales: Zhu, Dan, Wang, Junyi, Yang, Di, Xi, Jianzhong, Li, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706968/
https://www.ncbi.nlm.nih.gov/pubmed/34948095
http://dx.doi.org/10.3390/ijms222413301

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