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Exercise Effects on Bone Mineral Density in Men

In contrast to postmenopausal women, evidence for a favorable effect of exercise on Bone Mineral Density (BMD) is still limited for men. This might be due to the paucity of studies, but also to the great variety of participants and study characteristics that may dilute study results. The aim of the...

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Autores principales: Mages, Michelle, Shojaa, Mahdieh, Kohl, Matthias, von Stengel, Simon, Becker, Clemens, Gosch, Markus, Jakob, Franz, Kerschan-Schindl, Katharina, Kladny, Bernd, Klöckner, Nicole, Lange, Uwe, Middeldorf, Stefan, Peters, Stefan, Schoene, Daniel, Sieber, Cornel C., Tholen, Reina, Thomasius, Friederike E., Uder, Michael, Kemmler, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707095/
https://www.ncbi.nlm.nih.gov/pubmed/34959796
http://dx.doi.org/10.3390/nu13124244
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author Mages, Michelle
Shojaa, Mahdieh
Kohl, Matthias
von Stengel, Simon
Becker, Clemens
Gosch, Markus
Jakob, Franz
Kerschan-Schindl, Katharina
Kladny, Bernd
Klöckner, Nicole
Lange, Uwe
Middeldorf, Stefan
Peters, Stefan
Schoene, Daniel
Sieber, Cornel C.
Tholen, Reina
Thomasius, Friederike E.
Uder, Michael
Kemmler, Wolfgang
author_facet Mages, Michelle
Shojaa, Mahdieh
Kohl, Matthias
von Stengel, Simon
Becker, Clemens
Gosch, Markus
Jakob, Franz
Kerschan-Schindl, Katharina
Kladny, Bernd
Klöckner, Nicole
Lange, Uwe
Middeldorf, Stefan
Peters, Stefan
Schoene, Daniel
Sieber, Cornel C.
Tholen, Reina
Thomasius, Friederike E.
Uder, Michael
Kemmler, Wolfgang
author_sort Mages, Michelle
collection PubMed
description In contrast to postmenopausal women, evidence for a favorable effect of exercise on Bone Mineral Density (BMD) is still limited for men. This might be due to the paucity of studies, but also to the great variety of participants and study characteristics that may dilute study results. The aim of the present systematic review and meta-analysis was to evaluate the effect of exercise on BMD changes with rational eligibility criteria. A comprehensive search of six electronic databases up to 15 March 2021 was conducted. Briefly, controlled trials ≥6 months that determined changes in areal BMD in men >18 years old, with no apparent diseases or pharmacological therapy that relevantly affect bone metabolism, were included. BMD changes (standardized mean differences: SMD) of the lumbar spine (LS) and femoral neck (FN) were considered as outcomes. Twelve studies with 16 exercise and 12 control groups were identified. The pooled estimate of random-effect analysis was SMD = 0.38, 95%-CI: 0.14–0.61 and SMD = 0.25, 95%-CI: 0.00–0.49, for LS and FN, respectively. Heterogeneity between the trials was low–moderate. Funnel plots and rank and regression correlation tests indicate evidence for small study publication bias for LS but not FN-BMD. Subgroup analyses that focus on study length, type of exercise and methodologic quality revealed no significant difference between each of the three categories. In summary, we provided further evidence for a low but significant effect of exercise on BMD in men. However, we are currently unable to give even rough exercise recommendations for male cohorts.
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spelling pubmed-87070952021-12-25 Exercise Effects on Bone Mineral Density in Men Mages, Michelle Shojaa, Mahdieh Kohl, Matthias von Stengel, Simon Becker, Clemens Gosch, Markus Jakob, Franz Kerschan-Schindl, Katharina Kladny, Bernd Klöckner, Nicole Lange, Uwe Middeldorf, Stefan Peters, Stefan Schoene, Daniel Sieber, Cornel C. Tholen, Reina Thomasius, Friederike E. Uder, Michael Kemmler, Wolfgang Nutrients Systematic Review In contrast to postmenopausal women, evidence for a favorable effect of exercise on Bone Mineral Density (BMD) is still limited for men. This might be due to the paucity of studies, but also to the great variety of participants and study characteristics that may dilute study results. The aim of the present systematic review and meta-analysis was to evaluate the effect of exercise on BMD changes with rational eligibility criteria. A comprehensive search of six electronic databases up to 15 March 2021 was conducted. Briefly, controlled trials ≥6 months that determined changes in areal BMD in men >18 years old, with no apparent diseases or pharmacological therapy that relevantly affect bone metabolism, were included. BMD changes (standardized mean differences: SMD) of the lumbar spine (LS) and femoral neck (FN) were considered as outcomes. Twelve studies with 16 exercise and 12 control groups were identified. The pooled estimate of random-effect analysis was SMD = 0.38, 95%-CI: 0.14–0.61 and SMD = 0.25, 95%-CI: 0.00–0.49, for LS and FN, respectively. Heterogeneity between the trials was low–moderate. Funnel plots and rank and regression correlation tests indicate evidence for small study publication bias for LS but not FN-BMD. Subgroup analyses that focus on study length, type of exercise and methodologic quality revealed no significant difference between each of the three categories. In summary, we provided further evidence for a low but significant effect of exercise on BMD in men. However, we are currently unable to give even rough exercise recommendations for male cohorts. MDPI 2021-11-26 /pmc/articles/PMC8707095/ /pubmed/34959796 http://dx.doi.org/10.3390/nu13124244 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Mages, Michelle
Shojaa, Mahdieh
Kohl, Matthias
von Stengel, Simon
Becker, Clemens
Gosch, Markus
Jakob, Franz
Kerschan-Schindl, Katharina
Kladny, Bernd
Klöckner, Nicole
Lange, Uwe
Middeldorf, Stefan
Peters, Stefan
Schoene, Daniel
Sieber, Cornel C.
Tholen, Reina
Thomasius, Friederike E.
Uder, Michael
Kemmler, Wolfgang
Exercise Effects on Bone Mineral Density in Men
title Exercise Effects on Bone Mineral Density in Men
title_full Exercise Effects on Bone Mineral Density in Men
title_fullStr Exercise Effects on Bone Mineral Density in Men
title_full_unstemmed Exercise Effects on Bone Mineral Density in Men
title_short Exercise Effects on Bone Mineral Density in Men
title_sort exercise effects on bone mineral density in men
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707095/
https://www.ncbi.nlm.nih.gov/pubmed/34959796
http://dx.doi.org/10.3390/nu13124244
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