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CRF-R1 Antagonist Treatment Exacerbates Circadian Corticosterone Secretion under Chronic Stress, but Preserves HPA Feedback Sensitivity

Despite promising initial reports, corticotropin-releasing factor receptor type-1 (CRF-R1) antagonists have mostly failed to display efficacy in clinical trials for anxiety or depression. Rather than broad-spectrum antidepressant/anxiolytic-like drugs, they may represent an ‘antistress’ solution for...

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Detalles Bibliográficos
Autores principales:	Ibarguen-Vargas, Yadira, Leman, Samuel, Palme, Rupert, Belzung, Catherine, Surget, Alexandre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707167/ https://www.ncbi.nlm.nih.gov/pubmed/34959395 http://dx.doi.org/10.3390/pharmaceutics13122114

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