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PL1 Peptide Engages Acidic Surfaces on Tumor-Associated Fibronectin and Tenascin Isoforms to Trigger Cellular Uptake

Tumor extracellular matrix (ECM) is a high-capacity target for the precision delivery of affinity ligand-guided drugs and imaging agents. Recently, we developed a PL1 peptide (sequence: PPRRGLIKLKTS) for systemic targeting of malignant ECM. Here, we map the dynamics of PL1 binding to its receptors F...

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Detalles Bibliográficos
Autores principales:	Lingasamy, Prakash, Põšnograjeva, Kristina, Kopanchuk, Sergei, Tobi, Allan, Rinken, Ago, General, Ignacio J., Asciutto, Eliana K., Teesalu, Tambet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707168/ https://www.ncbi.nlm.nih.gov/pubmed/34959279 http://dx.doi.org/10.3390/pharmaceutics13121998

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