Drugs of Abuse and Their Impact on Viral Pathogenesis

Commonly misused substances such as alcohol, cocaine, heroin, methamphetamine, and opioids suppress immune responses and may impact viral pathogenesis. In recent years, illicit use of opioids has fueled outbreaks of several viral pathogens, including the human immunodeficiency virus (HIV), hepatitis...

Descripción completa

Detalles Bibliográficos
Autores principales: Blackard, Jason T., Sherman, Kenneth E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707190/
https://www.ncbi.nlm.nih.gov/pubmed/34960656
http://dx.doi.org/10.3390/v13122387
_version_ 1784622376243167232
author Blackard, Jason T.
Sherman, Kenneth E.
author_facet Blackard, Jason T.
Sherman, Kenneth E.
author_sort Blackard, Jason T.
collection PubMed
description Commonly misused substances such as alcohol, cocaine, heroin, methamphetamine, and opioids suppress immune responses and may impact viral pathogenesis. In recent years, illicit use of opioids has fueled outbreaks of several viral pathogens, including the human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). This review focuses on the myriad of mechanisms by which drugs of abuse impact viral replication and disease progression. Virus–drug interactions can accelerate viral disease progression and lead to increased risk of virus transmission.
format Online
Article
Text
id pubmed-8707190
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87071902021-12-25 Drugs of Abuse and Their Impact on Viral Pathogenesis Blackard, Jason T. Sherman, Kenneth E. Viruses Review Commonly misused substances such as alcohol, cocaine, heroin, methamphetamine, and opioids suppress immune responses and may impact viral pathogenesis. In recent years, illicit use of opioids has fueled outbreaks of several viral pathogens, including the human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV). This review focuses on the myriad of mechanisms by which drugs of abuse impact viral replication and disease progression. Virus–drug interactions can accelerate viral disease progression and lead to increased risk of virus transmission. MDPI 2021-11-29 /pmc/articles/PMC8707190/ /pubmed/34960656 http://dx.doi.org/10.3390/v13122387 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Blackard, Jason T.
Sherman, Kenneth E.
Drugs of Abuse and Their Impact on Viral Pathogenesis
title Drugs of Abuse and Their Impact on Viral Pathogenesis
title_full Drugs of Abuse and Their Impact on Viral Pathogenesis
title_fullStr Drugs of Abuse and Their Impact on Viral Pathogenesis
title_full_unstemmed Drugs of Abuse and Their Impact on Viral Pathogenesis
title_short Drugs of Abuse and Their Impact on Viral Pathogenesis
title_sort drugs of abuse and their impact on viral pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707190/
https://www.ncbi.nlm.nih.gov/pubmed/34960656
http://dx.doi.org/10.3390/v13122387
work_keys_str_mv AT blackardjasont drugsofabuseandtheirimpactonviralpathogenesis
AT shermankennethe drugsofabuseandtheirimpactonviralpathogenesis

Ejemplares similares