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Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry
Background: the admission and death causes of SLE patients might have changed over the last years. Methods: Analysis of the Spanish National Hospital Discharge database. All individuals admitted with SLE, according to ICD-9, were selected. The following five admission categories were considered: SLE...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707218/ https://www.ncbi.nlm.nih.gov/pubmed/34945045 http://dx.doi.org/10.3390/jcm10245749 |
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author | Moreno-Torres, Víctor Tarín, Carlos Ruiz-Irastorza, Guillermo Castejón, Raquel Gutiérrez-Rojas, Ángela Royuela, Ana Durán-del Campo, Pedro Mellor-Pita, Susana Tutor, Pablo Rosado, Silvia Sánchez, Enrique Martínez-Urbistondo, María de Mendoza, Carmen Yebra, Miguel Vargas, Juan-Antonio |
author_facet | Moreno-Torres, Víctor Tarín, Carlos Ruiz-Irastorza, Guillermo Castejón, Raquel Gutiérrez-Rojas, Ángela Royuela, Ana Durán-del Campo, Pedro Mellor-Pita, Susana Tutor, Pablo Rosado, Silvia Sánchez, Enrique Martínez-Urbistondo, María de Mendoza, Carmen Yebra, Miguel Vargas, Juan-Antonio |
author_sort | Moreno-Torres, Víctor |
collection | PubMed |
description | Background: the admission and death causes of SLE patients might have changed over the last years. Methods: Analysis of the Spanish National Hospital Discharge database. All individuals admitted with SLE, according to ICD-9, were selected. The following five admission categories were considered: SLE, cardiovascular disease (CVD), neoplasm, infection, and venous-thromboembolic disease (VTED), along four periods of time (1997–2000, 2001–2005, 2006–2010, and 2011–2015). Results: The admissions (99,859) from 43.432 patients with SLE were included. The absolute number of admissions increased from 15,807 in 1997–2000 to 31,977 in 2011–2015. SLE decreased as a cause of admission (from 47.1% to 20.8%, p < 0.001), while other categories increased over the time, as follows: 5% to 8.6% for CVD, 8.2% to 13% for infection, and 1.4% to 5.5% for neoplasm (p < 0.001 for all). The admission mortality rate rose from 2.22% to 3.06% (p < 0.001) and the causes of death evolved in parallel with the admission categories. A significant trend to older age was observed over time in the overall population and deceased patients (p < 0.001). Conclusions: Better control of SLE over the past two decades has led to a decrease in early admissions, and disease chronification. As a counterpart, CVD, infections, and neoplasm have become the main causes of admissions and mortality. |
format | Online Article Text |
id | pubmed-8707218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87072182021-12-25 Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry Moreno-Torres, Víctor Tarín, Carlos Ruiz-Irastorza, Guillermo Castejón, Raquel Gutiérrez-Rojas, Ángela Royuela, Ana Durán-del Campo, Pedro Mellor-Pita, Susana Tutor, Pablo Rosado, Silvia Sánchez, Enrique Martínez-Urbistondo, María de Mendoza, Carmen Yebra, Miguel Vargas, Juan-Antonio J Clin Med Article Background: the admission and death causes of SLE patients might have changed over the last years. Methods: Analysis of the Spanish National Hospital Discharge database. All individuals admitted with SLE, according to ICD-9, were selected. The following five admission categories were considered: SLE, cardiovascular disease (CVD), neoplasm, infection, and venous-thromboembolic disease (VTED), along four periods of time (1997–2000, 2001–2005, 2006–2010, and 2011–2015). Results: The admissions (99,859) from 43.432 patients with SLE were included. The absolute number of admissions increased from 15,807 in 1997–2000 to 31,977 in 2011–2015. SLE decreased as a cause of admission (from 47.1% to 20.8%, p < 0.001), while other categories increased over the time, as follows: 5% to 8.6% for CVD, 8.2% to 13% for infection, and 1.4% to 5.5% for neoplasm (p < 0.001 for all). The admission mortality rate rose from 2.22% to 3.06% (p < 0.001) and the causes of death evolved in parallel with the admission categories. A significant trend to older age was observed over time in the overall population and deceased patients (p < 0.001). Conclusions: Better control of SLE over the past two decades has led to a decrease in early admissions, and disease chronification. As a counterpart, CVD, infections, and neoplasm have become the main causes of admissions and mortality. MDPI 2021-12-08 /pmc/articles/PMC8707218/ /pubmed/34945045 http://dx.doi.org/10.3390/jcm10245749 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moreno-Torres, Víctor Tarín, Carlos Ruiz-Irastorza, Guillermo Castejón, Raquel Gutiérrez-Rojas, Ángela Royuela, Ana Durán-del Campo, Pedro Mellor-Pita, Susana Tutor, Pablo Rosado, Silvia Sánchez, Enrique Martínez-Urbistondo, María de Mendoza, Carmen Yebra, Miguel Vargas, Juan-Antonio Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry |
title | Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry |
title_full | Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry |
title_fullStr | Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry |
title_full_unstemmed | Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry |
title_short | Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry |
title_sort | trends in hospital admissions and death causes in patients with systemic lupus erythematosus: spanish national registry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707218/ https://www.ncbi.nlm.nih.gov/pubmed/34945045 http://dx.doi.org/10.3390/jcm10245749 |
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