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Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry

Background: the admission and death causes of SLE patients might have changed over the last years. Methods: Analysis of the Spanish National Hospital Discharge database. All individuals admitted with SLE, according to ICD-9, were selected. The following five admission categories were considered: SLE...

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Autores principales: Moreno-Torres, Víctor, Tarín, Carlos, Ruiz-Irastorza, Guillermo, Castejón, Raquel, Gutiérrez-Rojas, Ángela, Royuela, Ana, Durán-del Campo, Pedro, Mellor-Pita, Susana, Tutor, Pablo, Rosado, Silvia, Sánchez, Enrique, Martínez-Urbistondo, María, de Mendoza, Carmen, Yebra, Miguel, Vargas, Juan-Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707218/
https://www.ncbi.nlm.nih.gov/pubmed/34945045
http://dx.doi.org/10.3390/jcm10245749
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author Moreno-Torres, Víctor
Tarín, Carlos
Ruiz-Irastorza, Guillermo
Castejón, Raquel
Gutiérrez-Rojas, Ángela
Royuela, Ana
Durán-del Campo, Pedro
Mellor-Pita, Susana
Tutor, Pablo
Rosado, Silvia
Sánchez, Enrique
Martínez-Urbistondo, María
de Mendoza, Carmen
Yebra, Miguel
Vargas, Juan-Antonio
author_facet Moreno-Torres, Víctor
Tarín, Carlos
Ruiz-Irastorza, Guillermo
Castejón, Raquel
Gutiérrez-Rojas, Ángela
Royuela, Ana
Durán-del Campo, Pedro
Mellor-Pita, Susana
Tutor, Pablo
Rosado, Silvia
Sánchez, Enrique
Martínez-Urbistondo, María
de Mendoza, Carmen
Yebra, Miguel
Vargas, Juan-Antonio
author_sort Moreno-Torres, Víctor
collection PubMed
description Background: the admission and death causes of SLE patients might have changed over the last years. Methods: Analysis of the Spanish National Hospital Discharge database. All individuals admitted with SLE, according to ICD-9, were selected. The following five admission categories were considered: SLE, cardiovascular disease (CVD), neoplasm, infection, and venous-thromboembolic disease (VTED), along four periods of time (1997–2000, 2001–2005, 2006–2010, and 2011–2015). Results: The admissions (99,859) from 43.432 patients with SLE were included. The absolute number of admissions increased from 15,807 in 1997–2000 to 31,977 in 2011–2015. SLE decreased as a cause of admission (from 47.1% to 20.8%, p < 0.001), while other categories increased over the time, as follows: 5% to 8.6% for CVD, 8.2% to 13% for infection, and 1.4% to 5.5% for neoplasm (p < 0.001 for all). The admission mortality rate rose from 2.22% to 3.06% (p < 0.001) and the causes of death evolved in parallel with the admission categories. A significant trend to older age was observed over time in the overall population and deceased patients (p < 0.001). Conclusions: Better control of SLE over the past two decades has led to a decrease in early admissions, and disease chronification. As a counterpart, CVD, infections, and neoplasm have become the main causes of admissions and mortality.
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spelling pubmed-87072182021-12-25 Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry Moreno-Torres, Víctor Tarín, Carlos Ruiz-Irastorza, Guillermo Castejón, Raquel Gutiérrez-Rojas, Ángela Royuela, Ana Durán-del Campo, Pedro Mellor-Pita, Susana Tutor, Pablo Rosado, Silvia Sánchez, Enrique Martínez-Urbistondo, María de Mendoza, Carmen Yebra, Miguel Vargas, Juan-Antonio J Clin Med Article Background: the admission and death causes of SLE patients might have changed over the last years. Methods: Analysis of the Spanish National Hospital Discharge database. All individuals admitted with SLE, according to ICD-9, were selected. The following five admission categories were considered: SLE, cardiovascular disease (CVD), neoplasm, infection, and venous-thromboembolic disease (VTED), along four periods of time (1997–2000, 2001–2005, 2006–2010, and 2011–2015). Results: The admissions (99,859) from 43.432 patients with SLE were included. The absolute number of admissions increased from 15,807 in 1997–2000 to 31,977 in 2011–2015. SLE decreased as a cause of admission (from 47.1% to 20.8%, p < 0.001), while other categories increased over the time, as follows: 5% to 8.6% for CVD, 8.2% to 13% for infection, and 1.4% to 5.5% for neoplasm (p < 0.001 for all). The admission mortality rate rose from 2.22% to 3.06% (p < 0.001) and the causes of death evolved in parallel with the admission categories. A significant trend to older age was observed over time in the overall population and deceased patients (p < 0.001). Conclusions: Better control of SLE over the past two decades has led to a decrease in early admissions, and disease chronification. As a counterpart, CVD, infections, and neoplasm have become the main causes of admissions and mortality. MDPI 2021-12-08 /pmc/articles/PMC8707218/ /pubmed/34945045 http://dx.doi.org/10.3390/jcm10245749 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moreno-Torres, Víctor
Tarín, Carlos
Ruiz-Irastorza, Guillermo
Castejón, Raquel
Gutiérrez-Rojas, Ángela
Royuela, Ana
Durán-del Campo, Pedro
Mellor-Pita, Susana
Tutor, Pablo
Rosado, Silvia
Sánchez, Enrique
Martínez-Urbistondo, María
de Mendoza, Carmen
Yebra, Miguel
Vargas, Juan-Antonio
Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry
title Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry
title_full Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry
title_fullStr Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry
title_full_unstemmed Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry
title_short Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry
title_sort trends in hospital admissions and death causes in patients with systemic lupus erythematosus: spanish national registry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707218/
https://www.ncbi.nlm.nih.gov/pubmed/34945045
http://dx.doi.org/10.3390/jcm10245749
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