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Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer

Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these cha...

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Detalles Bibliográficos
Autores principales: Sassu, Carolina Maria, Palaia, Innocenza, Boccia, Serena Maria, Caruso, Giuseppe, Perniola, Giorgia, Tomao, Federica, Di Donato, Violante, Musella, Angela, Muzii, Ludovico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707281/
https://www.ncbi.nlm.nih.gov/pubmed/34948446
http://dx.doi.org/10.3390/ijms222413650
Descripción
Sumario:Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these challenging patients. Currently, most data can be obtained from tumor biopsy samples, but this is not always available and implies a surgical procedure. On the other hand, circulating biomarkers are detected with non-invasive methods, although this might require expensive techniques. Given the fervent hope in their value, here we focused on the most studied circulating biomarkers that could play a role in PtR OC.