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Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer
Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these cha...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707281/ https://www.ncbi.nlm.nih.gov/pubmed/34948446 http://dx.doi.org/10.3390/ijms222413650 |
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author | Sassu, Carolina Maria Palaia, Innocenza Boccia, Serena Maria Caruso, Giuseppe Perniola, Giorgia Tomao, Federica Di Donato, Violante Musella, Angela Muzii, Ludovico |
author_facet | Sassu, Carolina Maria Palaia, Innocenza Boccia, Serena Maria Caruso, Giuseppe Perniola, Giorgia Tomao, Federica Di Donato, Violante Musella, Angela Muzii, Ludovico |
author_sort | Sassu, Carolina Maria |
collection | PubMed |
description | Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these challenging patients. Currently, most data can be obtained from tumor biopsy samples, but this is not always available and implies a surgical procedure. On the other hand, circulating biomarkers are detected with non-invasive methods, although this might require expensive techniques. Given the fervent hope in their value, here we focused on the most studied circulating biomarkers that could play a role in PtR OC. |
format | Online Article Text |
id | pubmed-8707281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87072812021-12-25 Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer Sassu, Carolina Maria Palaia, Innocenza Boccia, Serena Maria Caruso, Giuseppe Perniola, Giorgia Tomao, Federica Di Donato, Violante Musella, Angela Muzii, Ludovico Int J Mol Sci Review Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these challenging patients. Currently, most data can be obtained from tumor biopsy samples, but this is not always available and implies a surgical procedure. On the other hand, circulating biomarkers are detected with non-invasive methods, although this might require expensive techniques. Given the fervent hope in their value, here we focused on the most studied circulating biomarkers that could play a role in PtR OC. MDPI 2021-12-20 /pmc/articles/PMC8707281/ /pubmed/34948446 http://dx.doi.org/10.3390/ijms222413650 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sassu, Carolina Maria Palaia, Innocenza Boccia, Serena Maria Caruso, Giuseppe Perniola, Giorgia Tomao, Federica Di Donato, Violante Musella, Angela Muzii, Ludovico Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer |
title | Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer |
title_full | Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer |
title_fullStr | Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer |
title_full_unstemmed | Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer |
title_short | Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer |
title_sort | role of circulating biomarkers in platinum-resistant ovarian cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707281/ https://www.ncbi.nlm.nih.gov/pubmed/34948446 http://dx.doi.org/10.3390/ijms222413650 |
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