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Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer

Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these cha...

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Autores principales: Sassu, Carolina Maria, Palaia, Innocenza, Boccia, Serena Maria, Caruso, Giuseppe, Perniola, Giorgia, Tomao, Federica, Di Donato, Violante, Musella, Angela, Muzii, Ludovico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707281/
https://www.ncbi.nlm.nih.gov/pubmed/34948446
http://dx.doi.org/10.3390/ijms222413650
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author Sassu, Carolina Maria
Palaia, Innocenza
Boccia, Serena Maria
Caruso, Giuseppe
Perniola, Giorgia
Tomao, Federica
Di Donato, Violante
Musella, Angela
Muzii, Ludovico
author_facet Sassu, Carolina Maria
Palaia, Innocenza
Boccia, Serena Maria
Caruso, Giuseppe
Perniola, Giorgia
Tomao, Federica
Di Donato, Violante
Musella, Angela
Muzii, Ludovico
author_sort Sassu, Carolina Maria
collection PubMed
description Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these challenging patients. Currently, most data can be obtained from tumor biopsy samples, but this is not always available and implies a surgical procedure. On the other hand, circulating biomarkers are detected with non-invasive methods, although this might require expensive techniques. Given the fervent hope in their value, here we focused on the most studied circulating biomarkers that could play a role in PtR OC.
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spelling pubmed-87072812021-12-25 Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer Sassu, Carolina Maria Palaia, Innocenza Boccia, Serena Maria Caruso, Giuseppe Perniola, Giorgia Tomao, Federica Di Donato, Violante Musella, Angela Muzii, Ludovico Int J Mol Sci Review Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these challenging patients. Currently, most data can be obtained from tumor biopsy samples, but this is not always available and implies a surgical procedure. On the other hand, circulating biomarkers are detected with non-invasive methods, although this might require expensive techniques. Given the fervent hope in their value, here we focused on the most studied circulating biomarkers that could play a role in PtR OC. MDPI 2021-12-20 /pmc/articles/PMC8707281/ /pubmed/34948446 http://dx.doi.org/10.3390/ijms222413650 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sassu, Carolina Maria
Palaia, Innocenza
Boccia, Serena Maria
Caruso, Giuseppe
Perniola, Giorgia
Tomao, Federica
Di Donato, Violante
Musella, Angela
Muzii, Ludovico
Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer
title Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer
title_full Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer
title_fullStr Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer
title_full_unstemmed Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer
title_short Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer
title_sort role of circulating biomarkers in platinum-resistant ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707281/
https://www.ncbi.nlm.nih.gov/pubmed/34948446
http://dx.doi.org/10.3390/ijms222413650
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