Cargando…

Effect of Botulinum Toxin Injection on the Progression of Hip Dislocation in Patients with Spastic Cerebral Palsy: A Pilot Study

Hip adductor spasticity is a contributing factor to hip dislocation in patients with cerebral palsy (CP). We hypothesized that botulinum toxin injected into the hip adductor muscles would reduce spasticity and help prevent hip dislocation. Twenty patients with bilateral spastic CP aged 2 to 10 years...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Yookyung, Lee, Seungeun, Jang, Joonyoung, Lim, Jiwoon, Ryu, Ju Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707328/
https://www.ncbi.nlm.nih.gov/pubmed/34941710
http://dx.doi.org/10.3390/toxins13120872
_version_ 1784622409829056512
author Lee, Yookyung
Lee, Seungeun
Jang, Joonyoung
Lim, Jiwoon
Ryu, Ju Seok
author_facet Lee, Yookyung
Lee, Seungeun
Jang, Joonyoung
Lim, Jiwoon
Ryu, Ju Seok
author_sort Lee, Yookyung
collection PubMed
description Hip adductor spasticity is a contributing factor to hip dislocation in patients with cerebral palsy (CP). We hypothesized that botulinum toxin injected into the hip adductor muscles would reduce spasticity and help prevent hip dislocation. Twenty patients with bilateral spastic CP aged 2 to 10 years with gross motor function classification system level IV or V were included. Botulinum toxin was injected into the hip adductor muscles at baseline and at 6-month follow-up. Muscle tone was measured with an eight-channel surface electromyography (EMG) recorder. A hip X-ray was performed, and Reimer’s hip migration index (MI) was measured. The Wilcoxon signed-rank test was used to compare the surface EMG values of the hip muscles at baseline and follow-up. The mean root mean square surface EMG value of the hip adductor muscles was significantly reduced at 1, 2, 3, and 7 months after the first injection, up to approximately 53% of the baseline. The 1-year progression of the hip MI was −0.04%. Repeated sessions of botulinum toxin injections at the hip adductor muscles significantly reduced muscle tone and hip displacement. A botulinum toxin injection may be used as an adjunctive treatment in the prevention of hip dislocation.
format Online
Article
Text
id pubmed-8707328
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87073282021-12-25 Effect of Botulinum Toxin Injection on the Progression of Hip Dislocation in Patients with Spastic Cerebral Palsy: A Pilot Study Lee, Yookyung Lee, Seungeun Jang, Joonyoung Lim, Jiwoon Ryu, Ju Seok Toxins (Basel) Article Hip adductor spasticity is a contributing factor to hip dislocation in patients with cerebral palsy (CP). We hypothesized that botulinum toxin injected into the hip adductor muscles would reduce spasticity and help prevent hip dislocation. Twenty patients with bilateral spastic CP aged 2 to 10 years with gross motor function classification system level IV or V were included. Botulinum toxin was injected into the hip adductor muscles at baseline and at 6-month follow-up. Muscle tone was measured with an eight-channel surface electromyography (EMG) recorder. A hip X-ray was performed, and Reimer’s hip migration index (MI) was measured. The Wilcoxon signed-rank test was used to compare the surface EMG values of the hip muscles at baseline and follow-up. The mean root mean square surface EMG value of the hip adductor muscles was significantly reduced at 1, 2, 3, and 7 months after the first injection, up to approximately 53% of the baseline. The 1-year progression of the hip MI was −0.04%. Repeated sessions of botulinum toxin injections at the hip adductor muscles significantly reduced muscle tone and hip displacement. A botulinum toxin injection may be used as an adjunctive treatment in the prevention of hip dislocation. MDPI 2021-12-06 /pmc/articles/PMC8707328/ /pubmed/34941710 http://dx.doi.org/10.3390/toxins13120872 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Yookyung
Lee, Seungeun
Jang, Joonyoung
Lim, Jiwoon
Ryu, Ju Seok
Effect of Botulinum Toxin Injection on the Progression of Hip Dislocation in Patients with Spastic Cerebral Palsy: A Pilot Study
title Effect of Botulinum Toxin Injection on the Progression of Hip Dislocation in Patients with Spastic Cerebral Palsy: A Pilot Study
title_full Effect of Botulinum Toxin Injection on the Progression of Hip Dislocation in Patients with Spastic Cerebral Palsy: A Pilot Study
title_fullStr Effect of Botulinum Toxin Injection on the Progression of Hip Dislocation in Patients with Spastic Cerebral Palsy: A Pilot Study
title_full_unstemmed Effect of Botulinum Toxin Injection on the Progression of Hip Dislocation in Patients with Spastic Cerebral Palsy: A Pilot Study
title_short Effect of Botulinum Toxin Injection on the Progression of Hip Dislocation in Patients with Spastic Cerebral Palsy: A Pilot Study
title_sort effect of botulinum toxin injection on the progression of hip dislocation in patients with spastic cerebral palsy: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707328/
https://www.ncbi.nlm.nih.gov/pubmed/34941710
http://dx.doi.org/10.3390/toxins13120872
work_keys_str_mv AT leeyookyung effectofbotulinumtoxininjectionontheprogressionofhipdislocationinpatientswithspasticcerebralpalsyapilotstudy
AT leeseungeun effectofbotulinumtoxininjectionontheprogressionofhipdislocationinpatientswithspasticcerebralpalsyapilotstudy
AT jangjoonyoung effectofbotulinumtoxininjectionontheprogressionofhipdislocationinpatientswithspasticcerebralpalsyapilotstudy
AT limjiwoon effectofbotulinumtoxininjectionontheprogressionofhipdislocationinpatientswithspasticcerebralpalsyapilotstudy
AT ryujuseok effectofbotulinumtoxininjectionontheprogressionofhipdislocationinpatientswithspasticcerebralpalsyapilotstudy