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Regulatory Peptides in Asthma

Numerous regulatory peptides play a critical role in the pathogenesis of airway inflammation, airflow obstruction and hyperresponsiveness, which are hallmarks of asthma. Some of them exacerbate asthma symptoms, such as neuropeptide Y and tachykinins, while others have ameliorating properties, such a...

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Autores principales: Kaczyńska, Katarzyna, Zając, Dominika, Wojciechowski, Piotr, Jampolska, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707337/
https://www.ncbi.nlm.nih.gov/pubmed/34948451
http://dx.doi.org/10.3390/ijms222413656
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author Kaczyńska, Katarzyna
Zając, Dominika
Wojciechowski, Piotr
Jampolska, Monika
author_facet Kaczyńska, Katarzyna
Zając, Dominika
Wojciechowski, Piotr
Jampolska, Monika
author_sort Kaczyńska, Katarzyna
collection PubMed
description Numerous regulatory peptides play a critical role in the pathogenesis of airway inflammation, airflow obstruction and hyperresponsiveness, which are hallmarks of asthma. Some of them exacerbate asthma symptoms, such as neuropeptide Y and tachykinins, while others have ameliorating properties, such as nociception, neurotensin or β-defensin 2. Interacting with peptide receptors located in the lungs or on immune cells opens up new therapeutic possibilities for the treatment of asthma, especially when it is resistant to available therapies. This article provides a concise review of the most important and current findings regarding the involvement of regulatory peptides in asthma pathology.
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spelling pubmed-87073372021-12-25 Regulatory Peptides in Asthma Kaczyńska, Katarzyna Zając, Dominika Wojciechowski, Piotr Jampolska, Monika Int J Mol Sci Review Numerous regulatory peptides play a critical role in the pathogenesis of airway inflammation, airflow obstruction and hyperresponsiveness, which are hallmarks of asthma. Some of them exacerbate asthma symptoms, such as neuropeptide Y and tachykinins, while others have ameliorating properties, such as nociception, neurotensin or β-defensin 2. Interacting with peptide receptors located in the lungs or on immune cells opens up new therapeutic possibilities for the treatment of asthma, especially when it is resistant to available therapies. This article provides a concise review of the most important and current findings regarding the involvement of regulatory peptides in asthma pathology. MDPI 2021-12-20 /pmc/articles/PMC8707337/ /pubmed/34948451 http://dx.doi.org/10.3390/ijms222413656 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kaczyńska, Katarzyna
Zając, Dominika
Wojciechowski, Piotr
Jampolska, Monika
Regulatory Peptides in Asthma
title Regulatory Peptides in Asthma
title_full Regulatory Peptides in Asthma
title_fullStr Regulatory Peptides in Asthma
title_full_unstemmed Regulatory Peptides in Asthma
title_short Regulatory Peptides in Asthma
title_sort regulatory peptides in asthma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707337/
https://www.ncbi.nlm.nih.gov/pubmed/34948451
http://dx.doi.org/10.3390/ijms222413656
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