Cargando…
Regulatory Peptides in Asthma
Numerous regulatory peptides play a critical role in the pathogenesis of airway inflammation, airflow obstruction and hyperresponsiveness, which are hallmarks of asthma. Some of them exacerbate asthma symptoms, such as neuropeptide Y and tachykinins, while others have ameliorating properties, such a...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707337/ https://www.ncbi.nlm.nih.gov/pubmed/34948451 http://dx.doi.org/10.3390/ijms222413656 |
_version_ | 1784622412018483200 |
---|---|
author | Kaczyńska, Katarzyna Zając, Dominika Wojciechowski, Piotr Jampolska, Monika |
author_facet | Kaczyńska, Katarzyna Zając, Dominika Wojciechowski, Piotr Jampolska, Monika |
author_sort | Kaczyńska, Katarzyna |
collection | PubMed |
description | Numerous regulatory peptides play a critical role in the pathogenesis of airway inflammation, airflow obstruction and hyperresponsiveness, which are hallmarks of asthma. Some of them exacerbate asthma symptoms, such as neuropeptide Y and tachykinins, while others have ameliorating properties, such as nociception, neurotensin or β-defensin 2. Interacting with peptide receptors located in the lungs or on immune cells opens up new therapeutic possibilities for the treatment of asthma, especially when it is resistant to available therapies. This article provides a concise review of the most important and current findings regarding the involvement of regulatory peptides in asthma pathology. |
format | Online Article Text |
id | pubmed-8707337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87073372021-12-25 Regulatory Peptides in Asthma Kaczyńska, Katarzyna Zając, Dominika Wojciechowski, Piotr Jampolska, Monika Int J Mol Sci Review Numerous regulatory peptides play a critical role in the pathogenesis of airway inflammation, airflow obstruction and hyperresponsiveness, which are hallmarks of asthma. Some of them exacerbate asthma symptoms, such as neuropeptide Y and tachykinins, while others have ameliorating properties, such as nociception, neurotensin or β-defensin 2. Interacting with peptide receptors located in the lungs or on immune cells opens up new therapeutic possibilities for the treatment of asthma, especially when it is resistant to available therapies. This article provides a concise review of the most important and current findings regarding the involvement of regulatory peptides in asthma pathology. MDPI 2021-12-20 /pmc/articles/PMC8707337/ /pubmed/34948451 http://dx.doi.org/10.3390/ijms222413656 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kaczyńska, Katarzyna Zając, Dominika Wojciechowski, Piotr Jampolska, Monika Regulatory Peptides in Asthma |
title | Regulatory Peptides in Asthma |
title_full | Regulatory Peptides in Asthma |
title_fullStr | Regulatory Peptides in Asthma |
title_full_unstemmed | Regulatory Peptides in Asthma |
title_short | Regulatory Peptides in Asthma |
title_sort | regulatory peptides in asthma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707337/ https://www.ncbi.nlm.nih.gov/pubmed/34948451 http://dx.doi.org/10.3390/ijms222413656 |
work_keys_str_mv | AT kaczynskakatarzyna regulatorypeptidesinasthma AT zajacdominika regulatorypeptidesinasthma AT wojciechowskipiotr regulatorypeptidesinasthma AT jampolskamonika regulatorypeptidesinasthma |