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Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis

Atherosclerotic diseases, including ischemic heart disease and stroke, are a main cause of mortality worldwide. Chronic vascular inflammation via immune dysregulation is critically involved in the pathogenesis of atherosclerosis. Accumulating evidence suggests that regulatory T cells (Tregs), respon...

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Detalles Bibliográficos
Autores principales: Tanaka, Toru, Sasaki, Naoto, Rikitake, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707380/
https://www.ncbi.nlm.nih.gov/pubmed/34945203
http://dx.doi.org/10.3390/jcm10245907
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author Tanaka, Toru
Sasaki, Naoto
Rikitake, Yoshiyuki
author_facet Tanaka, Toru
Sasaki, Naoto
Rikitake, Yoshiyuki
author_sort Tanaka, Toru
collection PubMed
description Atherosclerotic diseases, including ischemic heart disease and stroke, are a main cause of mortality worldwide. Chronic vascular inflammation via immune dysregulation is critically involved in the pathogenesis of atherosclerosis. Accumulating evidence suggests that regulatory T cells (Tregs), responsible for maintaining immunological tolerance and suppressing excessive immune responses, play an important role in preventing the development and progression of atherosclerosis through the regulation of pathogenic immunoinflammatory responses. Several strategies to prevent and treat atherosclerosis through the promotion of regulatory immune responses have been developed, and could be clinically applied for the treatment of atherosclerotic cardiovascular disease. In this review, we summarize recent advances in our understanding of the protective role of Tregs in atherosclerosis and discuss attractive approaches to treat atherosclerotic disease by augmenting regulatory immune responses.
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spelling pubmed-87073802021-12-25 Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis Tanaka, Toru Sasaki, Naoto Rikitake, Yoshiyuki J Clin Med Review Atherosclerotic diseases, including ischemic heart disease and stroke, are a main cause of mortality worldwide. Chronic vascular inflammation via immune dysregulation is critically involved in the pathogenesis of atherosclerosis. Accumulating evidence suggests that regulatory T cells (Tregs), responsible for maintaining immunological tolerance and suppressing excessive immune responses, play an important role in preventing the development and progression of atherosclerosis through the regulation of pathogenic immunoinflammatory responses. Several strategies to prevent and treat atherosclerosis through the promotion of regulatory immune responses have been developed, and could be clinically applied for the treatment of atherosclerotic cardiovascular disease. In this review, we summarize recent advances in our understanding of the protective role of Tregs in atherosclerosis and discuss attractive approaches to treat atherosclerotic disease by augmenting regulatory immune responses. MDPI 2021-12-16 /pmc/articles/PMC8707380/ /pubmed/34945203 http://dx.doi.org/10.3390/jcm10245907 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tanaka, Toru
Sasaki, Naoto
Rikitake, Yoshiyuki
Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis
title Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis
title_full Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis
title_fullStr Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis
title_full_unstemmed Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis
title_short Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis
title_sort recent advances on the role and therapeutic potential of regulatory t cells in atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707380/
https://www.ncbi.nlm.nih.gov/pubmed/34945203
http://dx.doi.org/10.3390/jcm10245907
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