Cargando…
Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis
Atherosclerotic diseases, including ischemic heart disease and stroke, are a main cause of mortality worldwide. Chronic vascular inflammation via immune dysregulation is critically involved in the pathogenesis of atherosclerosis. Accumulating evidence suggests that regulatory T cells (Tregs), respon...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707380/ https://www.ncbi.nlm.nih.gov/pubmed/34945203 http://dx.doi.org/10.3390/jcm10245907 |
_version_ | 1784622422640558080 |
---|---|
author | Tanaka, Toru Sasaki, Naoto Rikitake, Yoshiyuki |
author_facet | Tanaka, Toru Sasaki, Naoto Rikitake, Yoshiyuki |
author_sort | Tanaka, Toru |
collection | PubMed |
description | Atherosclerotic diseases, including ischemic heart disease and stroke, are a main cause of mortality worldwide. Chronic vascular inflammation via immune dysregulation is critically involved in the pathogenesis of atherosclerosis. Accumulating evidence suggests that regulatory T cells (Tregs), responsible for maintaining immunological tolerance and suppressing excessive immune responses, play an important role in preventing the development and progression of atherosclerosis through the regulation of pathogenic immunoinflammatory responses. Several strategies to prevent and treat atherosclerosis through the promotion of regulatory immune responses have been developed, and could be clinically applied for the treatment of atherosclerotic cardiovascular disease. In this review, we summarize recent advances in our understanding of the protective role of Tregs in atherosclerosis and discuss attractive approaches to treat atherosclerotic disease by augmenting regulatory immune responses. |
format | Online Article Text |
id | pubmed-8707380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87073802021-12-25 Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis Tanaka, Toru Sasaki, Naoto Rikitake, Yoshiyuki J Clin Med Review Atherosclerotic diseases, including ischemic heart disease and stroke, are a main cause of mortality worldwide. Chronic vascular inflammation via immune dysregulation is critically involved in the pathogenesis of atherosclerosis. Accumulating evidence suggests that regulatory T cells (Tregs), responsible for maintaining immunological tolerance and suppressing excessive immune responses, play an important role in preventing the development and progression of atherosclerosis through the regulation of pathogenic immunoinflammatory responses. Several strategies to prevent and treat atherosclerosis through the promotion of regulatory immune responses have been developed, and could be clinically applied for the treatment of atherosclerotic cardiovascular disease. In this review, we summarize recent advances in our understanding of the protective role of Tregs in atherosclerosis and discuss attractive approaches to treat atherosclerotic disease by augmenting regulatory immune responses. MDPI 2021-12-16 /pmc/articles/PMC8707380/ /pubmed/34945203 http://dx.doi.org/10.3390/jcm10245907 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tanaka, Toru Sasaki, Naoto Rikitake, Yoshiyuki Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis |
title | Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis |
title_full | Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis |
title_fullStr | Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis |
title_full_unstemmed | Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis |
title_short | Recent Advances on the Role and Therapeutic Potential of Regulatory T Cells in Atherosclerosis |
title_sort | recent advances on the role and therapeutic potential of regulatory t cells in atherosclerosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707380/ https://www.ncbi.nlm.nih.gov/pubmed/34945203 http://dx.doi.org/10.3390/jcm10245907 |
work_keys_str_mv | AT tanakatoru recentadvancesontheroleandtherapeuticpotentialofregulatorytcellsinatherosclerosis AT sasakinaoto recentadvancesontheroleandtherapeuticpotentialofregulatorytcellsinatherosclerosis AT rikitakeyoshiyuki recentadvancesontheroleandtherapeuticpotentialofregulatorytcellsinatherosclerosis |