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Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy
Diabetic retinopathy (DR) is a microvascular complication of diabetes in the retina. Chronic hyperglycemia damages retinal microvasculature embedded into the extracellular matrix (ECM), causing fluid leakage and ischemic retinal neovascularization. Current treatment strategies include intravitreal a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707400/ https://www.ncbi.nlm.nih.gov/pubmed/34947953 http://dx.doi.org/10.3390/life11121421 |
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author | Low, Shermaine W. Y. Vaidya, Tanuja Gadde, Santosh G. K. Mochi, Thirumalesh B. Kumar, Devesh Kassem, Iris S. Costakos, Deborah M. Ahmad, Baseer Sethu, Swaminathan Ghosh, Arkasubhra Chaurasia, Shyam S. |
author_facet | Low, Shermaine W. Y. Vaidya, Tanuja Gadde, Santosh G. K. Mochi, Thirumalesh B. Kumar, Devesh Kassem, Iris S. Costakos, Deborah M. Ahmad, Baseer Sethu, Swaminathan Ghosh, Arkasubhra Chaurasia, Shyam S. |
author_sort | Low, Shermaine W. Y. |
collection | PubMed |
description | Diabetic retinopathy (DR) is a microvascular complication of diabetes in the retina. Chronic hyperglycemia damages retinal microvasculature embedded into the extracellular matrix (ECM), causing fluid leakage and ischemic retinal neovascularization. Current treatment strategies include intravitreal anti-vascular endothelial growth factor (VEGF) or steroidal injections, laser photocoagulation, or vitrectomy in severe cases. However, treatment may require multiple modalities or repeat treatments due to variable response. Though DR management has achieved great success, improved, long-lasting, and predictable treatments are needed, including new biomarkers and therapeutic approaches. Small-leucine rich proteoglycans, such as decorin, constitute an integral component of retinal endothelial ECM. Therefore, any damage to microvasculature can trigger its antifibrotic and antiangiogenic response against retinal vascular pathologies, including DR. We conducted a cross-sectional study to examine the association between aqueous humor (AH) decorin levels, if any, and severity of DR. A total of 82 subjects (26 control, 56 DR) were recruited. AH was collected and decorin concentrations were measured using an enzyme-linked immunosorbent assay (ELISA). Decorin was significantly increased in the AH of DR subjects compared to controls (p = 0.0034). AH decorin levels were increased in severe DR groups in ETDRS and Gloucestershire classifications. Decorin concentrations also displayed a significant association with visual acuity (LogMAR) measurements. In conclusion, aqueous humor decorin concentrations were found elevated in DR subjects, possibly due to a compensatory response to the retinal microvascular changes during hyperglycemia. |
format | Online Article Text |
id | pubmed-8707400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87074002021-12-25 Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy Low, Shermaine W. Y. Vaidya, Tanuja Gadde, Santosh G. K. Mochi, Thirumalesh B. Kumar, Devesh Kassem, Iris S. Costakos, Deborah M. Ahmad, Baseer Sethu, Swaminathan Ghosh, Arkasubhra Chaurasia, Shyam S. Life (Basel) Article Diabetic retinopathy (DR) is a microvascular complication of diabetes in the retina. Chronic hyperglycemia damages retinal microvasculature embedded into the extracellular matrix (ECM), causing fluid leakage and ischemic retinal neovascularization. Current treatment strategies include intravitreal anti-vascular endothelial growth factor (VEGF) or steroidal injections, laser photocoagulation, or vitrectomy in severe cases. However, treatment may require multiple modalities or repeat treatments due to variable response. Though DR management has achieved great success, improved, long-lasting, and predictable treatments are needed, including new biomarkers and therapeutic approaches. Small-leucine rich proteoglycans, such as decorin, constitute an integral component of retinal endothelial ECM. Therefore, any damage to microvasculature can trigger its antifibrotic and antiangiogenic response against retinal vascular pathologies, including DR. We conducted a cross-sectional study to examine the association between aqueous humor (AH) decorin levels, if any, and severity of DR. A total of 82 subjects (26 control, 56 DR) were recruited. AH was collected and decorin concentrations were measured using an enzyme-linked immunosorbent assay (ELISA). Decorin was significantly increased in the AH of DR subjects compared to controls (p = 0.0034). AH decorin levels were increased in severe DR groups in ETDRS and Gloucestershire classifications. Decorin concentrations also displayed a significant association with visual acuity (LogMAR) measurements. In conclusion, aqueous humor decorin concentrations were found elevated in DR subjects, possibly due to a compensatory response to the retinal microvascular changes during hyperglycemia. MDPI 2021-12-17 /pmc/articles/PMC8707400/ /pubmed/34947953 http://dx.doi.org/10.3390/life11121421 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Low, Shermaine W. Y. Vaidya, Tanuja Gadde, Santosh G. K. Mochi, Thirumalesh B. Kumar, Devesh Kassem, Iris S. Costakos, Deborah M. Ahmad, Baseer Sethu, Swaminathan Ghosh, Arkasubhra Chaurasia, Shyam S. Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy |
title | Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy |
title_full | Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy |
title_fullStr | Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy |
title_full_unstemmed | Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy |
title_short | Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy |
title_sort | decorin concentrations in aqueous humor of patients with diabetic retinopathy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707400/ https://www.ncbi.nlm.nih.gov/pubmed/34947953 http://dx.doi.org/10.3390/life11121421 |
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