Cargando…

Virtual Screening in Search for a Chemical Probe for Angiotensin-Converting Enzyme 2 (ACE2)

We elaborate new models for ACE and ACE2 receptors with an excellent prediction power compared to previous models. We propose promising workflows for working with huge compound collections, thereby enabling us to discover optimized protocols for virtual screening management. The efficacy of elaborat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kravets, Iryna O., Dudenko, Dmytro V., Pashenko, Alexander E., Borisova, Tatiana A., Tolstanova, Ganna M., Ryabukhin, Sergey V., Volochnyuk, Dmitriy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707431/ https://www.ncbi.nlm.nih.gov/pubmed/34946667 http://dx.doi.org/10.3390/molecules26247584

Ejemplares similares

In Vitro Evaluation of In Silico Screening Approaches in Search for Selective ACE2 Binding Chemical Probes
por: Rayevsky, Alexey V., et al.
Publicado: (2022)

Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer’s disease brain
por: Ding, Qiyue, et al.
Publicado: (2020)

Angiotensin Converting Enzyme (ACE) and ACE2 Bind Integrins and ACE2 Regulates Integrin Signalling
por: Clarke, Nicola E., et al.
Publicado: (2012)

Manipulating angiotensin metabolism with angiotensin converting enzyme 2 (ACE2) in heart failure
por: Patel, Vaibhav B., et al.
Publicado: (2012)

Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19
por: Ni, Wentao, et al.
Publicado: (2020)

Characterization of Angiotensin Converting Enzyme-2 (ACE2) in Human Urine
por: Lew, Rebecca A., et al.
Publicado: (2006)

Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome
por: Gómez, Juan, et al.
Publicado: (2020)

Fluoral Hydrate: A Perspective Substrate for the Castagnoli–Cushman Reaction
por: Adamovskyi, Mykhailo I., et al.
Publicado: (2020)

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2
por: Clayton, Daniel, et al.
Publicado: (2015)

Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer’s Disease
por: Ding, Qiyue, et al.
Publicado: (2021)

The Race for ACE: Targeting Angiotensin-Converting Enzymes (ACE) in SARS-CoV-2 Infection
por: Schieffer, Elisabeth, et al.
Publicado: (2022)

Covid-19 and the angiotensin-converting enzyme (ACE2): Areas for research
por: Omar, Michael Brandon
Publicado: (2020)

Measurement of Angiotensin Converting Enzyme 2 Activity in Biological Fluid (ACE2)
por: Xiao, Fengxia, et al.
Publicado: (2017)

Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research
por: Abdul-Hafez, Amal, et al.
Publicado: (2021)

Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19
por: Kuba, Keiji, et al.
Publicado: (2021)

Three key proteases – angiotensin-I-converting enzyme (ACE), ACE2 and renin – within and beyond the renin-angiotensin system
por: Guang, Cuie, et al.
Publicado: (2012)

Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease
por: Tikellis, Chris, et al.
Publicado: (2012)

Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney
por: Jiang, Xiao, et al.
Publicado: (2020)

Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age
por: Tamanna, Sonia, et al.
Publicado: (2020)

Angiotensin Converting Enzyme 2 (ACE2) Expression in the Aged Brain and Visual System
por: Hill, James M., et al.
Publicado: (2021)

Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation
por: Turner, Anthony J., et al.
Publicado: (2022)

Purification and characterization of angiotensin converting enzyme 2 (ACE2) from murine model of mesangial cell in culture
por: Aragão, Danielle S., et al.
Publicado: (2011)

Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1–7) levels in experimental biliary fibrosis()
por: Herath, Chandana B., et al.
Publicado: (2007)

His345 mutant of angiotensin-converting enzyme 2 (ACE2) remains enzymatically active against angiotensin II
por: Liu, Pan, et al.
Publicado: (2021)

Human Angiotensin - Converting Enzyme 2 (ACE2) is a Receptor for Human Respiratory Coronavirus NL63
por: Smith, M. K., et al.
Publicado: (2006)

Calmodulin interacts with angiotensin‐converting enzyme‐2 (ACE2) and inhibits shedding of its ectodomain
por: Lambert, Daniel W., et al.
Publicado: (2008)

Exposure to Particulate Matter Increases Expression of the Angiotensin converting enzyme-2 (ACE2) Receptor
por: Miyashita, Lisa, et al.
Publicado: (2022)

Corrigendum: Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age
por: Tamanna, Sonia, et al.
Publicado: (2021)

Higher angiotensin-converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer’s disease
por: Reveret, Louise, et al.
Publicado: (2023)

The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae
por: Burnham, Susan, et al.
Publicado: (2005)

Angiotensin converting enzyme gene polymorphism and influence of ACE inhibition
por: Arman, Q.
Publicado: (2010)

Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator
por: Bian, Jingwei, et al.
Publicado: (2021)

SARS-CoV-2, the Angiotensin Converting Enzyme 2 (ACE2) Receptor and Alzheimer’s disease
por: Lukiw, Walter J.
Publicado: (2021)

Angiotensin converting enzyme-2 (ACE2) and its possible roles in hypertension, diabetes and cardiac function
por: Warner, Fiona J., et al.
Publicado: (2003)

Angiotensin Converting Enzyme-2 (ACE2) and its Possible Roles in Hypertension, Diabetes and Cardiac Function
por: Warner, Fiona J., et al.
Publicado: (2003)

Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiring mechanical ventilation
por: Baker, Steven Andrew, et al.
Publicado: (2021)

The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection
por: Kaseb, Ahmed O., et al.
Publicado: (2021)

Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies
por: Abubakar, Murtala Bello, et al.
Publicado: (2021)

The dynamic nature of the coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia
por: Manna, Vincent J., et al.
Publicado: (2022)

Higher Angiotensin I Converting Enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer’s disease
por: Louise, Reveret, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rt61s9s48updg0981mat0v8jlm