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The Consumption of Food-Based Iodine in the Immediate Pre-Pregnancy Period in Madrid Is Insufficient. San Carlos and Pregnancy Cohort Study

A pre-gestational thyroid reserve of iodine is crucial to guarantee the increased demand for thyroid hormone production of early pregnancy. An iodine intake ≥150 µg/day is currently recommended. The objective of this study was to assess average pre-gestational food-based iodine consumption in pregna...

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Detalles Bibliográficos
Autores principales: Melero, Verónica, Runkle, Isabelle, Garcia de la Torre, Nuria, De Miguel, Paz, Valerio, Johanna, del Valle, Laura, Barabash, Ana, Sanabria, Concepción, Moraga, Inmaculada, Familiar, Cristina, Durán, Alejandra, Torrejón, Maria Jose, Diaz, Jose Angel, Cuesta, Martin, Ruiz, Jorge Grabiel, Jiménez, Inés, Pazos, Mario, Herraiz, Miguel Angel, Izquierdo, Nuria, Pérez, Noelia, Matia, Pilar, Perez-Ferre, Natalia, Marcuello, Clara, Rubio, Miguel Angel, Calle-Pascual, Alfonso Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707458/
https://www.ncbi.nlm.nih.gov/pubmed/34960010
http://dx.doi.org/10.3390/nu13124458
Descripción
Sumario:A pre-gestational thyroid reserve of iodine is crucial to guarantee the increased demand for thyroid hormone production of early pregnancy. An iodine intake ≥150 µg/day is currently recommended. The objective of this study was to assess average pre-gestational food-based iodine consumption in pregnant women at their first prenatal visit (<12 gestational weeks), and its association with adverse materno-fetal events (history of miscarriages, early fetal losses, Gestational Diabetes, prematurity, caesarean sections, and new-borns large/small for gestational age). Between 2015–2017, 2523 normoglycemic women out of 3026 eligible had data in the modified Diabetes Nutrition and Complication Trial (DNCT) questionnaire permitting assessment of pre-gestational food-based iodine consumption, and were included in this study. Daily food-based iodine intake was 123 ± 48 µg, with 1922 (76.1%) not reaching 150 µg/day. Attaining this amount was associated with consuming 8 weekly servings of vegetables (3.84; 3.16–4.65), 1 of shellfish (8.72; 6.96–10.93) and/or 2 daily dairy products (6.43; 5.27–7.86). Women who reached a pre-gestational intake ≥150 µg had lower rates of hypothyroxinemia (104 (17.3%)/384 (21.4%); p = 0.026), a lower miscarriage rate, and a decrease in the composite of materno-fetal adverse events (0.81; 0.67–0.98). Reaching the recommended iodine pre-pregnancy intake with foods could benefit the progression of pregnancy.