A Prebiotic Ribosylation of Pyrimidine Nucleobases Enabled by Metal Cations and Clay Minerals

We report a prebiotically relevant solution to the N1-ribosylation of pyrimidine nucleobases, a well-known challenge to the RNA world hypothesis. We found that the presence of metal cations and clay minerals enable the previously unachievable direct ribosylation of uracil. Spectroscopy and chromatog...

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Detalles Bibliográficos
Autores principales: Chen, Qian-Qian, Zhao, Ze-Run, Wang, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707481/
https://www.ncbi.nlm.nih.gov/pubmed/34947911
http://dx.doi.org/10.3390/life11121381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707481/
https://www.ncbi.nlm.nih.gov/pubmed/34947911
http://dx.doi.org/10.3390/life11121381

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