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A Prebiotic Ribosylation of Pyrimidine Nucleobases Enabled by Metal Cations and Clay Minerals

We report a prebiotically relevant solution to the N1-ribosylation of pyrimidine nucleobases, a well-known challenge to the RNA world hypothesis. We found that the presence of metal cations and clay minerals enable the previously unachievable direct ribosylation of uracil. Spectroscopy and chromatog...

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Detalles Bibliográficos
Autores principales:	Chen, Qian-Qian, Zhao, Ze-Run, Wang, Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707481/ https://www.ncbi.nlm.nih.gov/pubmed/34947911 http://dx.doi.org/10.3390/life11121381

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