Cargando…

Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer’s Disease

Store-operated calcium entry (SOCE) constitutes a fine-tuning mechanism responsible for the replenishment of intracellular stores. Hippocampal SOCE is regulated by store-operated channels (SOC) organized in tripartite complex TRPC6/ORAI2/STIM2. It is suggested that in neurons, SOCE maintains intrace...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hunanyan, Lernik, Ghamaryan, Viktor, Makichyan, Ani, Popugaeva, Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707499/ https://www.ncbi.nlm.nih.gov/pubmed/34948414 http://dx.doi.org/10.3390/ijms222413618

Ejemplares similares

Piperazine Derivative Stabilizes Actin Filaments in Primary Fibroblasts and Binds G-Actin In Silico
por: Zernov, Nikita, et al.
Publicado: (2022)

CaMKIIβ knockdown decreases store-operated calcium entry in hippocampal dendritic spines
por: Zernov, Nikita, et al.
Publicado: (2022)

Store-operated calcium channels in skin
por: Manning, Declan, et al.
Publicado: (2022)

Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes
Publicado: (1996)

A Store-operated Calcium Channel in Drosophila S2 Cells
por: Yeromin, Andriy V., et al.
Publicado: (2004)

Reduction of blood pressure by store‐operated calcium channel blockers
por: Xu, Yan‐Jun, et al.
Publicado: (2015)

Structures reveal opening of the store-operated calcium channel Orai
por: Hou, Xiaowei, et al.
Publicado: (2018)

Store-Operated Calcium Channels as Drug Target in Gastroesophageal Cancers
por: Chang, Yan, et al.
Publicado: (2021)

Direct control of store-operated calcium channels by ultrafast laser
por: Cheng, Pan, et al.
Publicado: (2021)

Store-Operated Calcium Channels Are Involved in Spontaneous Slow Calcium Oscillations in Striatal Neurons
por: Kikuta, Satomi, et al.
Publicado: (2019)

The Blockade of Store-Operated Calcium Channels Improves Decompression Sickness in Rats
por: Tang, Shih-En, et al.
Publicado: (2020)

Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System
por: Zhang, Isis, et al.
Publicado: (2020)

Suppression of Store-operated Calcium Entry Channels and Cytokine Release by Cannabinoids
por: Kozak, J Ashot
Publicado: (2022)

Role of presynaptic calcium stores for neural network dysfunction in Alzheimer's disease
por: Lerdkrai, Chommanad, et al.
Publicado: (2018)

Dysregulation of Neuronal Calcium Signaling via Store-Operated Channels in Huntington's Disease
por: Czeredys, Magdalena
Publicado: (2020)

Regulation of store-operated calcium entry
por: Kodakandla, Goutham, et al.
Publicado: (2023)

Monovalent Permeability, Rectification, and Ionic Block of Store-operated Calcium Channels in Jurkat T Lymphocytes
por: Kerschbaum, Hubert H., et al.
Publicado: (1998)

Store operated calcium channels are associated with diabetic cystopathy in streptozotocin-induced diabetic rats
por: Yang, Sen, et al.
Publicado: (2018)

Activation and regulation of store-operated calcium entry
por: Smyth, Jeremy T, et al.
Publicado: (2010)

The heterogeneity of store-operated calcium entry in melanoma
por: Hooper, Robert, et al.
Publicado: (2016)

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels
por: Rana, Anshul, et al.
Publicado: (2015)

STIM1 Protein Activates Store-Operated Calcium Channels in Cellular Model of Huntington’s Disease
por: Vigont, V. A., et al.
Publicado: (2014)

A key role for STIM1 in store operated calcium channel activation in airway smooth muscle
por: Peel, Samantha E, et al.
Publicado: (2006)

Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain
por: Chauvet, Sylvain, et al.
Publicado: (2016)

Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes
por: Wen, Hairuo, et al.
Publicado: (2018)

Store-Operated Calcium Channels Control Proliferation and Self-Renewal of Cancer Stem Cells from Glioblastoma
por: Terrié, Elodie, et al.
Publicado: (2021)

Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes
por: Hoth, Markus, et al.
Publicado: (1997)

CLCA2 is a positive regulator of store-operated calcium entry and TMEM16A
por: Sharma, Aarushi, et al.
Publicado: (2018)

Erratum to “TRPC1: The link between functionally distinct store-operated calcium channels” [Cell Calcium 42 (2007) 213–223]
por: Ambudkar, Indu S., et al.
Publicado: (2008)

CRACking the structure of Orai: New work reveals the intramolecular properties of a store-operated, calcium influx channel
por: Braun, Andrew P.
Publicado: (2013)

Corrigendum: Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain
por: Chauvet, Sylvain, et al.
Publicado: (2017)

Orai3 Regulates Pancreatic Cancer Metastasis by Encoding a Functional Store Operated Calcium Entry Channel
por: Arora, Samriddhi, et al.
Publicado: (2021)

STIM and Orai1 Variants in Store-Operated Calcium Entry
por: Rosado, Juan A., et al.
Publicado: (2016)

Development of Store-Operated Calcium Entry-Targeted Compounds in Cancer
por: Liang, Xiaojing, et al.
Publicado: (2021)

Store Operated Calcium Entry in Cell Migration and Cancer Metastasis
por: Hammad, Ayat S., et al.
Publicado: (2021)

Celastrol inhibits store operated calcium entry and suppresses psoriasis
por: Yuan, Xiaoman, et al.
Publicado: (2023)

The role of neuronal calcium sensors in balancing synaptic plasticity and synaptic dysfunction
por: Kerrigan, Talitha L., et al.
Publicado: (2012)

Store-operated calcium entry is essential for glial calcium signalling in CNS white matter
por: Papanikolaou, M., et al.
Publicado: (2017)

Norepinephrine-Induced Calcium Signaling and Store-Operated Calcium Entry in Olfactory Bulb Astrocytes
por: Fischer, Timo, et al.
Publicado: (2021)

Molecular Components of Store-Operated Calcium Channels in the Regulation of Neural Stem Cell Physiology, Neurogenesis, and the Pathology of Huntington’s Disease
por: Latoszek, Ewelina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p94tn7h7lqs490bsqeudhfhqhn