Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer’s Disease

Store-operated calcium entry (SOCE) constitutes a fine-tuning mechanism responsible for the replenishment of intracellular stores. Hippocampal SOCE is regulated by store-operated channels (SOC) organized in tripartite complex TRPC6/ORAI2/STIM2. It is suggested that in neurons, SOCE maintains intrace...

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Detalles Bibliográficos
Autores principales: Hunanyan, Lernik, Ghamaryan, Viktor, Makichyan, Ani, Popugaeva, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707499/
https://www.ncbi.nlm.nih.gov/pubmed/34948414
http://dx.doi.org/10.3390/ijms222413618

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