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From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma
Neuroblastoma is a pediatric tumor arising from the sympatho-adrenal lineage and a worldwide leading cause of childhood cancer-related deaths. About half of high-risk patients die from the disease while survivors suffer from multiple therapy-related side-effects. While neuroblastomas present with a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707517/ https://www.ncbi.nlm.nih.gov/pubmed/34945759 http://dx.doi.org/10.3390/jpm11121286 |
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author | Decaesteker, Bieke Durinck, Kaat Van Roy, Nadine De Wilde, Bram Van Neste, Christophe Van Haver, Stéphane Roberts, Stephen De Preter, Katleen Vermeirssen, Vanessa Speleman, Frank |
author_facet | Decaesteker, Bieke Durinck, Kaat Van Roy, Nadine De Wilde, Bram Van Neste, Christophe Van Haver, Stéphane Roberts, Stephen De Preter, Katleen Vermeirssen, Vanessa Speleman, Frank |
author_sort | Decaesteker, Bieke |
collection | PubMed |
description | Neuroblastoma is a pediatric tumor arising from the sympatho-adrenal lineage and a worldwide leading cause of childhood cancer-related deaths. About half of high-risk patients die from the disease while survivors suffer from multiple therapy-related side-effects. While neuroblastomas present with a low mutational burden, focal and large segmental DNA copy number aberrations are highly recurrent and associated with poor survival. It can be assumed that the affected chromosomal regions contain critical genes implicated in neuroblastoma biology and behavior. More specifically, evidence has emerged that several of these genes are implicated in tumor dependencies thus potentially providing novel therapeutic entry points. In this review, we briefly review the current status of recurrent DNA copy number aberrations in neuroblastoma and provide an overview of the genes affected by these genomic variants for which a direct role in neuroblastoma has been established. Several of these genes are implicated in networks that positively regulate MYCN expression or stability as well as cell cycle control and apoptosis. Finally, we summarize alternative approaches to identify and prioritize candidate copy-number driven dependency genes for neuroblastoma offering novel therapeutic opportunities. |
format | Online Article Text |
id | pubmed-8707517 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87075172021-12-25 From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma Decaesteker, Bieke Durinck, Kaat Van Roy, Nadine De Wilde, Bram Van Neste, Christophe Van Haver, Stéphane Roberts, Stephen De Preter, Katleen Vermeirssen, Vanessa Speleman, Frank J Pers Med Review Neuroblastoma is a pediatric tumor arising from the sympatho-adrenal lineage and a worldwide leading cause of childhood cancer-related deaths. About half of high-risk patients die from the disease while survivors suffer from multiple therapy-related side-effects. While neuroblastomas present with a low mutational burden, focal and large segmental DNA copy number aberrations are highly recurrent and associated with poor survival. It can be assumed that the affected chromosomal regions contain critical genes implicated in neuroblastoma biology and behavior. More specifically, evidence has emerged that several of these genes are implicated in tumor dependencies thus potentially providing novel therapeutic entry points. In this review, we briefly review the current status of recurrent DNA copy number aberrations in neuroblastoma and provide an overview of the genes affected by these genomic variants for which a direct role in neuroblastoma has been established. Several of these genes are implicated in networks that positively regulate MYCN expression or stability as well as cell cycle control and apoptosis. Finally, we summarize alternative approaches to identify and prioritize candidate copy-number driven dependency genes for neuroblastoma offering novel therapeutic opportunities. MDPI 2021-12-03 /pmc/articles/PMC8707517/ /pubmed/34945759 http://dx.doi.org/10.3390/jpm11121286 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Decaesteker, Bieke Durinck, Kaat Van Roy, Nadine De Wilde, Bram Van Neste, Christophe Van Haver, Stéphane Roberts, Stephen De Preter, Katleen Vermeirssen, Vanessa Speleman, Frank From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma |
title | From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma |
title_full | From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma |
title_fullStr | From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma |
title_full_unstemmed | From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma |
title_short | From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma |
title_sort | from dna copy number gains and tumor dependencies to novel therapeutic targets for high-risk neuroblastoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707517/ https://www.ncbi.nlm.nih.gov/pubmed/34945759 http://dx.doi.org/10.3390/jpm11121286 |
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