Cargando…

Artemisinin and Derivatives-Based Hybrid Compounds: Promising Therapeutics for the Treatment of Cancer and Malaria

Cancer and malaria are major health conditions around the world despite many strategies and therapeutics available for their treatment. The most used strategy for the treatment of these diseases is the administration of therapeutic drugs, which suffer from several shortcomings. Some of the pharmacol...

Descripción completa

Detalles Bibliográficos
Autores principales: Peter, Sijongesonke, Jama, Siphesihle, Alven, Sibusiso, Aderibigbe, Blessing A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707619/
https://www.ncbi.nlm.nih.gov/pubmed/34946603
http://dx.doi.org/10.3390/molecules26247521
_version_ 1784622480554459136
author Peter, Sijongesonke
Jama, Siphesihle
Alven, Sibusiso
Aderibigbe, Blessing A.
author_facet Peter, Sijongesonke
Jama, Siphesihle
Alven, Sibusiso
Aderibigbe, Blessing A.
author_sort Peter, Sijongesonke
collection PubMed
description Cancer and malaria are major health conditions around the world despite many strategies and therapeutics available for their treatment. The most used strategy for the treatment of these diseases is the administration of therapeutic drugs, which suffer from several shortcomings. Some of the pharmacological limitations associated with these drugs are multi-drug resistance, drug toxicity, poor biocompatibility and bioavailability, and poor water solubility. The currently ongoing preclinical studies have demonstrated that combination therapy is a potent approach that can overcome some of the aforementioned limitations. Artemisinin and its derivatives have been reported to exhibit potent efficacy as anticancer and antimalarial agents. This review reports hybrid compounds containing artemisinin scaffolds and their derivatives with promising therapeutic effects for the treatment of cancer and malaria.
format Online
Article
Text
id pubmed-8707619
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87076192021-12-25 Artemisinin and Derivatives-Based Hybrid Compounds: Promising Therapeutics for the Treatment of Cancer and Malaria Peter, Sijongesonke Jama, Siphesihle Alven, Sibusiso Aderibigbe, Blessing A. Molecules Review Cancer and malaria are major health conditions around the world despite many strategies and therapeutics available for their treatment. The most used strategy for the treatment of these diseases is the administration of therapeutic drugs, which suffer from several shortcomings. Some of the pharmacological limitations associated with these drugs are multi-drug resistance, drug toxicity, poor biocompatibility and bioavailability, and poor water solubility. The currently ongoing preclinical studies have demonstrated that combination therapy is a potent approach that can overcome some of the aforementioned limitations. Artemisinin and its derivatives have been reported to exhibit potent efficacy as anticancer and antimalarial agents. This review reports hybrid compounds containing artemisinin scaffolds and their derivatives with promising therapeutic effects for the treatment of cancer and malaria. MDPI 2021-12-11 /pmc/articles/PMC8707619/ /pubmed/34946603 http://dx.doi.org/10.3390/molecules26247521 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Peter, Sijongesonke
Jama, Siphesihle
Alven, Sibusiso
Aderibigbe, Blessing A.
Artemisinin and Derivatives-Based Hybrid Compounds: Promising Therapeutics for the Treatment of Cancer and Malaria
title Artemisinin and Derivatives-Based Hybrid Compounds: Promising Therapeutics for the Treatment of Cancer and Malaria
title_full Artemisinin and Derivatives-Based Hybrid Compounds: Promising Therapeutics for the Treatment of Cancer and Malaria
title_fullStr Artemisinin and Derivatives-Based Hybrid Compounds: Promising Therapeutics for the Treatment of Cancer and Malaria
title_full_unstemmed Artemisinin and Derivatives-Based Hybrid Compounds: Promising Therapeutics for the Treatment of Cancer and Malaria
title_short Artemisinin and Derivatives-Based Hybrid Compounds: Promising Therapeutics for the Treatment of Cancer and Malaria
title_sort artemisinin and derivatives-based hybrid compounds: promising therapeutics for the treatment of cancer and malaria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707619/
https://www.ncbi.nlm.nih.gov/pubmed/34946603
http://dx.doi.org/10.3390/molecules26247521
work_keys_str_mv AT petersijongesonke artemisininandderivativesbasedhybridcompoundspromisingtherapeuticsforthetreatmentofcancerandmalaria
AT jamasiphesihle artemisininandderivativesbasedhybridcompoundspromisingtherapeuticsforthetreatmentofcancerandmalaria
AT alvensibusiso artemisininandderivativesbasedhybridcompoundspromisingtherapeuticsforthetreatmentofcancerandmalaria
AT aderibigbeblessinga artemisininandderivativesbasedhybridcompoundspromisingtherapeuticsforthetreatmentofcancerandmalaria