Cargando…

An Experimental and Numerical Study of Polyelectrolyte Hydrogel Ionic Diodes: Towards Electrical Detection of Charged Biomolecules

Polyelectrolyte hydrogel ionic diodes (PHIDs) have recently emerged as a unique set of iontronic devices. Such diodes are built on microfluidic chips that feature polyelectrolyte hydrogel junctions and rectify ionic currents owing to the heterogeneous distribution and transport of ions across the ju...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiong, Chenwei, Zhang, Boyin, Zhang, Rong, Liu, Yifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707621/
https://www.ncbi.nlm.nih.gov/pubmed/34960374
http://dx.doi.org/10.3390/s21248279
_version_ 1784622481012686848
author Xiong, Chenwei
Zhang, Boyin
Zhang, Rong
Liu, Yifan
author_facet Xiong, Chenwei
Zhang, Boyin
Zhang, Rong
Liu, Yifan
author_sort Xiong, Chenwei
collection PubMed
description Polyelectrolyte hydrogel ionic diodes (PHIDs) have recently emerged as a unique set of iontronic devices. Such diodes are built on microfluidic chips that feature polyelectrolyte hydrogel junctions and rectify ionic currents owing to the heterogeneous distribution and transport of ions across the junctions. In this paper, we provide the first account of a study on the ion transport behavior of PHIDs through an experimental investigation and numerical simulation. The effects of bulk ionic strength and hydrogel pore confinement are experimentally investigated. The ionic current rectification (ICR) exhibits saturation in a micromolar regime and responds to hydrogel pore size, which is subsequently verified in a simulation. Furthermore, we experimentally show that the rectification is sensitive to the dose of immobilized DNA with an exhibited sensitivity of 1 ng/μL. We anticipate our findings would be beneficial to the design of PHID-based biosensors for electrical detection of charged biomolecules.
format Online
Article
Text
id pubmed-8707621
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87076212021-12-25 An Experimental and Numerical Study of Polyelectrolyte Hydrogel Ionic Diodes: Towards Electrical Detection of Charged Biomolecules Xiong, Chenwei Zhang, Boyin Zhang, Rong Liu, Yifan Sensors (Basel) Article Polyelectrolyte hydrogel ionic diodes (PHIDs) have recently emerged as a unique set of iontronic devices. Such diodes are built on microfluidic chips that feature polyelectrolyte hydrogel junctions and rectify ionic currents owing to the heterogeneous distribution and transport of ions across the junctions. In this paper, we provide the first account of a study on the ion transport behavior of PHIDs through an experimental investigation and numerical simulation. The effects of bulk ionic strength and hydrogel pore confinement are experimentally investigated. The ionic current rectification (ICR) exhibits saturation in a micromolar regime and responds to hydrogel pore size, which is subsequently verified in a simulation. Furthermore, we experimentally show that the rectification is sensitive to the dose of immobilized DNA with an exhibited sensitivity of 1 ng/μL. We anticipate our findings would be beneficial to the design of PHID-based biosensors for electrical detection of charged biomolecules. MDPI 2021-12-10 /pmc/articles/PMC8707621/ /pubmed/34960374 http://dx.doi.org/10.3390/s21248279 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xiong, Chenwei
Zhang, Boyin
Zhang, Rong
Liu, Yifan
An Experimental and Numerical Study of Polyelectrolyte Hydrogel Ionic Diodes: Towards Electrical Detection of Charged Biomolecules
title An Experimental and Numerical Study of Polyelectrolyte Hydrogel Ionic Diodes: Towards Electrical Detection of Charged Biomolecules
title_full An Experimental and Numerical Study of Polyelectrolyte Hydrogel Ionic Diodes: Towards Electrical Detection of Charged Biomolecules
title_fullStr An Experimental and Numerical Study of Polyelectrolyte Hydrogel Ionic Diodes: Towards Electrical Detection of Charged Biomolecules
title_full_unstemmed An Experimental and Numerical Study of Polyelectrolyte Hydrogel Ionic Diodes: Towards Electrical Detection of Charged Biomolecules
title_short An Experimental and Numerical Study of Polyelectrolyte Hydrogel Ionic Diodes: Towards Electrical Detection of Charged Biomolecules
title_sort experimental and numerical study of polyelectrolyte hydrogel ionic diodes: towards electrical detection of charged biomolecules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707621/
https://www.ncbi.nlm.nih.gov/pubmed/34960374
http://dx.doi.org/10.3390/s21248279
work_keys_str_mv AT xiongchenwei anexperimentalandnumericalstudyofpolyelectrolytehydrogelionicdiodestowardselectricaldetectionofchargedbiomolecules
AT zhangboyin anexperimentalandnumericalstudyofpolyelectrolytehydrogelionicdiodestowardselectricaldetectionofchargedbiomolecules
AT zhangrong anexperimentalandnumericalstudyofpolyelectrolytehydrogelionicdiodestowardselectricaldetectionofchargedbiomolecules
AT liuyifan anexperimentalandnumericalstudyofpolyelectrolytehydrogelionicdiodestowardselectricaldetectionofchargedbiomolecules
AT xiongchenwei experimentalandnumericalstudyofpolyelectrolytehydrogelionicdiodestowardselectricaldetectionofchargedbiomolecules
AT zhangboyin experimentalandnumericalstudyofpolyelectrolytehydrogelionicdiodestowardselectricaldetectionofchargedbiomolecules
AT zhangrong experimentalandnumericalstudyofpolyelectrolytehydrogelionicdiodestowardselectricaldetectionofchargedbiomolecules
AT liuyifan experimentalandnumericalstudyofpolyelectrolytehydrogelionicdiodestowardselectricaldetectionofchargedbiomolecules