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Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex
Fusarium spp. are moulds ubiquitously distributed in nature and only occasionally pathogenic for humans. Species of the Fusarium solani complex are the predominant keratitis-inducing pathogens, because they are endowed with proper virulence factors. These fungi can adhere to the cornea creating a bi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707679/ https://www.ncbi.nlm.nih.gov/pubmed/34947075 http://dx.doi.org/10.3390/jof7121093 |
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author | Schrecker, Jens Seitz, Berthold Berger, Tim Daas, Loay Behrens-Baumann, Wolfgang Auw-Hädrich, Claudia Schütt, Sabine Kerl, Sabine Rentner-Andres, Sascha Hof, Herbert |
author_facet | Schrecker, Jens Seitz, Berthold Berger, Tim Daas, Loay Behrens-Baumann, Wolfgang Auw-Hädrich, Claudia Schütt, Sabine Kerl, Sabine Rentner-Andres, Sascha Hof, Herbert |
author_sort | Schrecker, Jens |
collection | PubMed |
description | Fusarium spp. are moulds ubiquitously distributed in nature and only occasionally pathogenic for humans. Species of the Fusarium solani complex are the predominant keratitis-inducing pathogens, because they are endowed with proper virulence factors. These fungi can adhere to the cornea creating a biofilm and, with the help of enzymes and cytotoxins, penetrate the cornea. Whereas an intact cornea is hardly able to be invaded by Fusarium spp. in spite of appropriate virulence factors, these opportunistic fungi may profit from predisposing conditions, for example mechanical injuries. This can lead to a progressive course of corneal infection and may finally affect the whole eye up to the need for enucleation. Here, we present and discuss the clinical, microbiological and histopathological aspects of a particular case due to Fusarium tonkinense of the Fusarium solani complex with severe consequences in a patient without any obvious predisposing factors. A broad portfolio of antifungal agents was applied, both topically and systemically as well as two penetrating keratoplasties were performed. The exact determination of the etiologic agent of the fungal infection proved likewise to be very challenging. |
format | Online Article Text |
id | pubmed-8707679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87076792021-12-25 Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex Schrecker, Jens Seitz, Berthold Berger, Tim Daas, Loay Behrens-Baumann, Wolfgang Auw-Hädrich, Claudia Schütt, Sabine Kerl, Sabine Rentner-Andres, Sascha Hof, Herbert J Fungi (Basel) Case Report Fusarium spp. are moulds ubiquitously distributed in nature and only occasionally pathogenic for humans. Species of the Fusarium solani complex are the predominant keratitis-inducing pathogens, because they are endowed with proper virulence factors. These fungi can adhere to the cornea creating a biofilm and, with the help of enzymes and cytotoxins, penetrate the cornea. Whereas an intact cornea is hardly able to be invaded by Fusarium spp. in spite of appropriate virulence factors, these opportunistic fungi may profit from predisposing conditions, for example mechanical injuries. This can lead to a progressive course of corneal infection and may finally affect the whole eye up to the need for enucleation. Here, we present and discuss the clinical, microbiological and histopathological aspects of a particular case due to Fusarium tonkinense of the Fusarium solani complex with severe consequences in a patient without any obvious predisposing factors. A broad portfolio of antifungal agents was applied, both topically and systemically as well as two penetrating keratoplasties were performed. The exact determination of the etiologic agent of the fungal infection proved likewise to be very challenging. MDPI 2021-12-18 /pmc/articles/PMC8707679/ /pubmed/34947075 http://dx.doi.org/10.3390/jof7121093 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Schrecker, Jens Seitz, Berthold Berger, Tim Daas, Loay Behrens-Baumann, Wolfgang Auw-Hädrich, Claudia Schütt, Sabine Kerl, Sabine Rentner-Andres, Sascha Hof, Herbert Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex |
title | Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex |
title_full | Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex |
title_fullStr | Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex |
title_full_unstemmed | Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex |
title_short | Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex |
title_sort | malignant keratitis caused by a highly-resistant strain of fusarium tonkinense from the fusarium solani complex |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707679/ https://www.ncbi.nlm.nih.gov/pubmed/34947075 http://dx.doi.org/10.3390/jof7121093 |
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