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Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex

Fusarium spp. are moulds ubiquitously distributed in nature and only occasionally pathogenic for humans. Species of the Fusarium solani complex are the predominant keratitis-inducing pathogens, because they are endowed with proper virulence factors. These fungi can adhere to the cornea creating a bi...

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Autores principales: Schrecker, Jens, Seitz, Berthold, Berger, Tim, Daas, Loay, Behrens-Baumann, Wolfgang, Auw-Hädrich, Claudia, Schütt, Sabine, Kerl, Sabine, Rentner-Andres, Sascha, Hof, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707679/
https://www.ncbi.nlm.nih.gov/pubmed/34947075
http://dx.doi.org/10.3390/jof7121093
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author Schrecker, Jens
Seitz, Berthold
Berger, Tim
Daas, Loay
Behrens-Baumann, Wolfgang
Auw-Hädrich, Claudia
Schütt, Sabine
Kerl, Sabine
Rentner-Andres, Sascha
Hof, Herbert
author_facet Schrecker, Jens
Seitz, Berthold
Berger, Tim
Daas, Loay
Behrens-Baumann, Wolfgang
Auw-Hädrich, Claudia
Schütt, Sabine
Kerl, Sabine
Rentner-Andres, Sascha
Hof, Herbert
author_sort Schrecker, Jens
collection PubMed
description Fusarium spp. are moulds ubiquitously distributed in nature and only occasionally pathogenic for humans. Species of the Fusarium solani complex are the predominant keratitis-inducing pathogens, because they are endowed with proper virulence factors. These fungi can adhere to the cornea creating a biofilm and, with the help of enzymes and cytotoxins, penetrate the cornea. Whereas an intact cornea is hardly able to be invaded by Fusarium spp. in spite of appropriate virulence factors, these opportunistic fungi may profit from predisposing conditions, for example mechanical injuries. This can lead to a progressive course of corneal infection and may finally affect the whole eye up to the need for enucleation. Here, we present and discuss the clinical, microbiological and histopathological aspects of a particular case due to Fusarium tonkinense of the Fusarium solani complex with severe consequences in a patient without any obvious predisposing factors. A broad portfolio of antifungal agents was applied, both topically and systemically as well as two penetrating keratoplasties were performed. The exact determination of the etiologic agent of the fungal infection proved likewise to be very challenging.
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spelling pubmed-87076792021-12-25 Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex Schrecker, Jens Seitz, Berthold Berger, Tim Daas, Loay Behrens-Baumann, Wolfgang Auw-Hädrich, Claudia Schütt, Sabine Kerl, Sabine Rentner-Andres, Sascha Hof, Herbert J Fungi (Basel) Case Report Fusarium spp. are moulds ubiquitously distributed in nature and only occasionally pathogenic for humans. Species of the Fusarium solani complex are the predominant keratitis-inducing pathogens, because they are endowed with proper virulence factors. These fungi can adhere to the cornea creating a biofilm and, with the help of enzymes and cytotoxins, penetrate the cornea. Whereas an intact cornea is hardly able to be invaded by Fusarium spp. in spite of appropriate virulence factors, these opportunistic fungi may profit from predisposing conditions, for example mechanical injuries. This can lead to a progressive course of corneal infection and may finally affect the whole eye up to the need for enucleation. Here, we present and discuss the clinical, microbiological and histopathological aspects of a particular case due to Fusarium tonkinense of the Fusarium solani complex with severe consequences in a patient without any obvious predisposing factors. A broad portfolio of antifungal agents was applied, both topically and systemically as well as two penetrating keratoplasties were performed. The exact determination of the etiologic agent of the fungal infection proved likewise to be very challenging. MDPI 2021-12-18 /pmc/articles/PMC8707679/ /pubmed/34947075 http://dx.doi.org/10.3390/jof7121093 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Schrecker, Jens
Seitz, Berthold
Berger, Tim
Daas, Loay
Behrens-Baumann, Wolfgang
Auw-Hädrich, Claudia
Schütt, Sabine
Kerl, Sabine
Rentner-Andres, Sascha
Hof, Herbert
Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex
title Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex
title_full Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex
title_fullStr Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex
title_full_unstemmed Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex
title_short Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex
title_sort malignant keratitis caused by a highly-resistant strain of fusarium tonkinense from the fusarium solani complex
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707679/
https://www.ncbi.nlm.nih.gov/pubmed/34947075
http://dx.doi.org/10.3390/jof7121093
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