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Predictors of the Development of Protracted Bacterial Bronchitis following Presentation to Healthcare for an Acute Respiratory Illness with Cough: Analysis of Three Cohort Studies

We describe the prevalence and risk factors for protracted bacterial bronchitis (PBB) following healthcare presentation for an acute cough illness in children. Data from three studies of the development of chronic cough (CC) in children were combined. PBB was defined as a wet cough of at least 4-wee...

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Autores principales: O’Grady, Kerry-Ann F., Mahon, Juliana, Arnold, Daniel, Grimwood, Keith, Hall, Kerry K., Goyal, Vikas, Marchant, Julie M., Phillips, Natalie, Acworth, Jason, King, Alex, Scott, Mark, Chang, Anne B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707704/
https://www.ncbi.nlm.nih.gov/pubmed/34945030
http://dx.doi.org/10.3390/jcm10245735
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author O’Grady, Kerry-Ann F.
Mahon, Juliana
Arnold, Daniel
Grimwood, Keith
Hall, Kerry K.
Goyal, Vikas
Marchant, Julie M.
Phillips, Natalie
Acworth, Jason
King, Alex
Scott, Mark
Chang, Anne B.
author_facet O’Grady, Kerry-Ann F.
Mahon, Juliana
Arnold, Daniel
Grimwood, Keith
Hall, Kerry K.
Goyal, Vikas
Marchant, Julie M.
Phillips, Natalie
Acworth, Jason
King, Alex
Scott, Mark
Chang, Anne B.
author_sort O’Grady, Kerry-Ann F.
collection PubMed
description We describe the prevalence and risk factors for protracted bacterial bronchitis (PBB) following healthcare presentation for an acute cough illness in children. Data from three studies of the development of chronic cough (CC) in children were combined. PBB was defined as a wet cough of at least 4-weeks duration with no identified specific cause of cough that resolved following 2–4 weeks of appropriate antibiotics. Anterior nasal swabs were tested for 17 viruses and bacteria by polymerase chain reaction. The study included 903 children. Childcare attendance (adjusted relative risk (aRR) = 2.32, 95% CI 1.48–3.63), prior history of chronic cough (aRR = 2.63, 95% CI 1.72–4.01) and age <2-years (<12-months: aRR = 4.31, 95% CI 1.42–13.10; 12-<24 months: aRR = 2.00, 95% CI 1.35–2.96) increased risk of PBB. Baseline diagnoses of asthma/reactive airways disease (aRR = 0.30, 95% CI 0.26–0.35) or bronchiolitis (aRR = 0.15, 95% CI 0.06–0.38) decreased risk. M. catarrhalis was the most common organism (52.4%) identified in all children (PBB = 72.1%; no PBB = 50.2%, p < 0.001). We provide the first data on risks for PBB in children following acute illness and a hypothesis for studies to further investigate the relationship with wheeze-related illnesses. Clinicians and parents/guardians should be aware of these risks and seek early review if a wet cough lasting more than 4-weeks develops the post-acute illness.
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spelling pubmed-87077042021-12-25 Predictors of the Development of Protracted Bacterial Bronchitis following Presentation to Healthcare for an Acute Respiratory Illness with Cough: Analysis of Three Cohort Studies O’Grady, Kerry-Ann F. Mahon, Juliana Arnold, Daniel Grimwood, Keith Hall, Kerry K. Goyal, Vikas Marchant, Julie M. Phillips, Natalie Acworth, Jason King, Alex Scott, Mark Chang, Anne B. J Clin Med Article We describe the prevalence and risk factors for protracted bacterial bronchitis (PBB) following healthcare presentation for an acute cough illness in children. Data from three studies of the development of chronic cough (CC) in children were combined. PBB was defined as a wet cough of at least 4-weeks duration with no identified specific cause of cough that resolved following 2–4 weeks of appropriate antibiotics. Anterior nasal swabs were tested for 17 viruses and bacteria by polymerase chain reaction. The study included 903 children. Childcare attendance (adjusted relative risk (aRR) = 2.32, 95% CI 1.48–3.63), prior history of chronic cough (aRR = 2.63, 95% CI 1.72–4.01) and age <2-years (<12-months: aRR = 4.31, 95% CI 1.42–13.10; 12-<24 months: aRR = 2.00, 95% CI 1.35–2.96) increased risk of PBB. Baseline diagnoses of asthma/reactive airways disease (aRR = 0.30, 95% CI 0.26–0.35) or bronchiolitis (aRR = 0.15, 95% CI 0.06–0.38) decreased risk. M. catarrhalis was the most common organism (52.4%) identified in all children (PBB = 72.1%; no PBB = 50.2%, p < 0.001). We provide the first data on risks for PBB in children following acute illness and a hypothesis for studies to further investigate the relationship with wheeze-related illnesses. Clinicians and parents/guardians should be aware of these risks and seek early review if a wet cough lasting more than 4-weeks develops the post-acute illness. MDPI 2021-12-07 /pmc/articles/PMC8707704/ /pubmed/34945030 http://dx.doi.org/10.3390/jcm10245735 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
O’Grady, Kerry-Ann F.
Mahon, Juliana
Arnold, Daniel
Grimwood, Keith
Hall, Kerry K.
Goyal, Vikas
Marchant, Julie M.
Phillips, Natalie
Acworth, Jason
King, Alex
Scott, Mark
Chang, Anne B.
Predictors of the Development of Protracted Bacterial Bronchitis following Presentation to Healthcare for an Acute Respiratory Illness with Cough: Analysis of Three Cohort Studies
title Predictors of the Development of Protracted Bacterial Bronchitis following Presentation to Healthcare for an Acute Respiratory Illness with Cough: Analysis of Three Cohort Studies
title_full Predictors of the Development of Protracted Bacterial Bronchitis following Presentation to Healthcare for an Acute Respiratory Illness with Cough: Analysis of Three Cohort Studies
title_fullStr Predictors of the Development of Protracted Bacterial Bronchitis following Presentation to Healthcare for an Acute Respiratory Illness with Cough: Analysis of Three Cohort Studies
title_full_unstemmed Predictors of the Development of Protracted Bacterial Bronchitis following Presentation to Healthcare for an Acute Respiratory Illness with Cough: Analysis of Three Cohort Studies
title_short Predictors of the Development of Protracted Bacterial Bronchitis following Presentation to Healthcare for an Acute Respiratory Illness with Cough: Analysis of Three Cohort Studies
title_sort predictors of the development of protracted bacterial bronchitis following presentation to healthcare for an acute respiratory illness with cough: analysis of three cohort studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707704/
https://www.ncbi.nlm.nih.gov/pubmed/34945030
http://dx.doi.org/10.3390/jcm10245735
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