Cargando…

Chronic, Mild Vestibulopathy Leads to Deficits in Spatial Tasks that Rely on Vestibular Input While Leaving Other Cognitive Functions and Brain Volumes Intact

Objectives: In this study, based on the known vestibulo-hippocampal connections, we asked whether mild chronic vestibulopathy leads only to vestibular-related deficits or whether there are effects on hippocampal function, structure, and cognition in general. In more detail, we assessed whether chron...

Descripción completa

Detalles Bibliográficos
Autores principales: Dordevic, Milos, Sulzer, Sabrina, Barche, Doreen, Dieterich, Marianne, Arens, Christoph, Müller, Notger G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707705/
https://www.ncbi.nlm.nih.gov/pubmed/34947900
http://dx.doi.org/10.3390/life11121369
_version_ 1784622501386518528
author Dordevic, Milos
Sulzer, Sabrina
Barche, Doreen
Dieterich, Marianne
Arens, Christoph
Müller, Notger G.
author_facet Dordevic, Milos
Sulzer, Sabrina
Barche, Doreen
Dieterich, Marianne
Arens, Christoph
Müller, Notger G.
author_sort Dordevic, Milos
collection PubMed
description Objectives: In this study, based on the known vestibulo-hippocampal connections, we asked whether mild chronic vestibulopathy leads only to vestibular-related deficits or whether there are effects on hippocampal function, structure, and cognition in general. In more detail, we assessed whether chronic vestibulopathy leads to (a) deficits in vestibular tasks without cognitive demand (balancing), (b) deficits in spatial cognitive tasks that require vestibular input (path integration, rotational memory), (c) deficits in spatial cognitive tasks that do not rely on vestibular input, (d) deficits in general cognitive function, and (e) atrophy in the brain. Methods: A total of 15 patients with chronic uni- or bilateral vestibulopathy (56.8 ± 10.1 years; 4 females) were included in this study and were age- and gender-matched by the control participants (57.6 ± 10.5) in a pairwise manner. Given their clinical symptoms and their deficits of the vestibulo-ocular reflex (VOR) the patients could be classified as being mildly affected. All participants of the underwent the following tests: clinical balance (CBT), triangle completion (TCT) for path integration, rotational memory (RM), the visuo-spatial subset of the Berlin intelligence structure test (BIS-4) and d2-R for attention and concentration, and a structural MRI for gray matter analysis using voxel-based morphometry (VBM). Results: Compared to the healthy controls, the vestibulopathy patients performed significantly worse in terms of CBT, TCT, and RM but showed no differences in terms of the BIS-4 and d2-R. There were also no significant volumetric gray matter differences between the two groups. Conclusions: This study provides evidence that both non-cognitive and cognitive functions that rely on vestibular input (balancing, path integration, rotational memory) are impaired, even in mild chronic vestibulopathy, while other cognitive functions, which rely on visual input (visuo-spatial memory, attention), are unimpaired in this condition, together with an overall intact brain structure. These findings may reflect a segregation between vestibular- and visual-dependent processes in the medial temporal lobe on the one hand and a structure–function dissociation on the other.
format Online
Article
Text
id pubmed-8707705
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87077052021-12-25 Chronic, Mild Vestibulopathy Leads to Deficits in Spatial Tasks that Rely on Vestibular Input While Leaving Other Cognitive Functions and Brain Volumes Intact Dordevic, Milos Sulzer, Sabrina Barche, Doreen Dieterich, Marianne Arens, Christoph Müller, Notger G. Life (Basel) Article Objectives: In this study, based on the known vestibulo-hippocampal connections, we asked whether mild chronic vestibulopathy leads only to vestibular-related deficits or whether there are effects on hippocampal function, structure, and cognition in general. In more detail, we assessed whether chronic vestibulopathy leads to (a) deficits in vestibular tasks without cognitive demand (balancing), (b) deficits in spatial cognitive tasks that require vestibular input (path integration, rotational memory), (c) deficits in spatial cognitive tasks that do not rely on vestibular input, (d) deficits in general cognitive function, and (e) atrophy in the brain. Methods: A total of 15 patients with chronic uni- or bilateral vestibulopathy (56.8 ± 10.1 years; 4 females) were included in this study and were age- and gender-matched by the control participants (57.6 ± 10.5) in a pairwise manner. Given their clinical symptoms and their deficits of the vestibulo-ocular reflex (VOR) the patients could be classified as being mildly affected. All participants of the underwent the following tests: clinical balance (CBT), triangle completion (TCT) for path integration, rotational memory (RM), the visuo-spatial subset of the Berlin intelligence structure test (BIS-4) and d2-R for attention and concentration, and a structural MRI for gray matter analysis using voxel-based morphometry (VBM). Results: Compared to the healthy controls, the vestibulopathy patients performed significantly worse in terms of CBT, TCT, and RM but showed no differences in terms of the BIS-4 and d2-R. There were also no significant volumetric gray matter differences between the two groups. Conclusions: This study provides evidence that both non-cognitive and cognitive functions that rely on vestibular input (balancing, path integration, rotational memory) are impaired, even in mild chronic vestibulopathy, while other cognitive functions, which rely on visual input (visuo-spatial memory, attention), are unimpaired in this condition, together with an overall intact brain structure. These findings may reflect a segregation between vestibular- and visual-dependent processes in the medial temporal lobe on the one hand and a structure–function dissociation on the other. MDPI 2021-12-09 /pmc/articles/PMC8707705/ /pubmed/34947900 http://dx.doi.org/10.3390/life11121369 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dordevic, Milos
Sulzer, Sabrina
Barche, Doreen
Dieterich, Marianne
Arens, Christoph
Müller, Notger G.
Chronic, Mild Vestibulopathy Leads to Deficits in Spatial Tasks that Rely on Vestibular Input While Leaving Other Cognitive Functions and Brain Volumes Intact
title Chronic, Mild Vestibulopathy Leads to Deficits in Spatial Tasks that Rely on Vestibular Input While Leaving Other Cognitive Functions and Brain Volumes Intact
title_full Chronic, Mild Vestibulopathy Leads to Deficits in Spatial Tasks that Rely on Vestibular Input While Leaving Other Cognitive Functions and Brain Volumes Intact
title_fullStr Chronic, Mild Vestibulopathy Leads to Deficits in Spatial Tasks that Rely on Vestibular Input While Leaving Other Cognitive Functions and Brain Volumes Intact
title_full_unstemmed Chronic, Mild Vestibulopathy Leads to Deficits in Spatial Tasks that Rely on Vestibular Input While Leaving Other Cognitive Functions and Brain Volumes Intact
title_short Chronic, Mild Vestibulopathy Leads to Deficits in Spatial Tasks that Rely on Vestibular Input While Leaving Other Cognitive Functions and Brain Volumes Intact
title_sort chronic, mild vestibulopathy leads to deficits in spatial tasks that rely on vestibular input while leaving other cognitive functions and brain volumes intact
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707705/
https://www.ncbi.nlm.nih.gov/pubmed/34947900
http://dx.doi.org/10.3390/life11121369
work_keys_str_mv AT dordevicmilos chronicmildvestibulopathyleadstodeficitsinspatialtasksthatrelyonvestibularinputwhileleavingothercognitivefunctionsandbrainvolumesintact
AT sulzersabrina chronicmildvestibulopathyleadstodeficitsinspatialtasksthatrelyonvestibularinputwhileleavingothercognitivefunctionsandbrainvolumesintact
AT barchedoreen chronicmildvestibulopathyleadstodeficitsinspatialtasksthatrelyonvestibularinputwhileleavingothercognitivefunctionsandbrainvolumesintact
AT dieterichmarianne chronicmildvestibulopathyleadstodeficitsinspatialtasksthatrelyonvestibularinputwhileleavingothercognitivefunctionsandbrainvolumesintact
AT arenschristoph chronicmildvestibulopathyleadstodeficitsinspatialtasksthatrelyonvestibularinputwhileleavingothercognitivefunctionsandbrainvolumesintact
AT mullernotgerg chronicmildvestibulopathyleadstodeficitsinspatialtasksthatrelyonvestibularinputwhileleavingothercognitivefunctionsandbrainvolumesintact